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1-19 of 19
Keywords: l-arginine
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Articles
Tumour cell growth in culture: dependence on arginine
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Journal:
Clinical Science
Clin Sci (Lond) (2004) 107 (4): 371–379.
Published: 24 September 2004
... mmol/l arginine and 2 g/litre bicarbonate (Life Technologies, Paisley, Scotland, U.K.) supplemented with 5% (v/v) FCS (fetal calf serum; ICN Flow, Thame, Oxfordshire, U.K.), penicillin (50 units/ml), streptomycin (50 mg/ml; Sigma, St. Louis, MO, U.S.A.) and fungizone (2.5 mg/ml; ICN Flow...
Articles
Acute Escherichia coli endotoxaemia decreases the plasma l-arginine/asymmetrical dimethylarginine ratio in humans
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Journal:
Clinical Science
Clin Sci (Lond) (2004) 106 (6): 577–581.
Published: 01 June 2004
...Friedrich MITTERMAYER; Khodadad NAMIRANIAN; Johannes PLEINER; Georg SCHALLER; Michael WOLZT Acute inflammation impairs vascular function. Based on the association between endothelial dysfunction and plasma concentrations of L -arginine and the endogenous nitric oxide synthase inhibitor ADMA...
Articles
Role of the l-arginine/nitric oxide pathway in ischaemic/reoxygenation injury of the human myocardium
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Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (6): 497–504.
Published: 07 November 2000
...Jin-Gang ZHANG; Manuel GALIÑANES The role of the L -arginine/nitric oxide (NO) pathway in myocardial ischaemic/reperfusion injury remains controversial in experimental animal models. The aim of the present studies was to investigate the role of this pathway in the human myocardium. Myocardial...
Articles
Is l-arginine infusion an adequate tool to assess endothelium-dependent vasodilation of the human renal vasculature?
Available to PurchaseMarkus P. SCHLAICH, Johannes JACOBI, Stefan JOHN, Christian DELLES, Ingrid FLEISCHMANN, Roland E. SCHMIEDER
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (4): 293–302.
Published: 06 September 2000
...Markus P. SCHLAICH; Johannes JACOBI; Stefan JOHN; Christian DELLES; Ingrid FLEISCHMANN; Roland E. SCHMIEDER Systemic administration of L -arginine alters renal haemodynamics in humans. We examined whether L -arginine-induced vasodilation of the renal vasculature is related to an increased...
Articles
Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia
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Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (2): 199–207.
Published: 01 February 1999
...Oranee TANGPHAO; Stephan CHALON; Heitor MORENO, JR.; Brian B. HOFFMAN; Terrence F. BLASCHKE Acute administration of L -arginine, the precursor of endothelial nitric oxide, has been shown to improve endothelial function in hypercholesterolaemic rabbits and humans. Animal studies suggest...
Articles
Effect of sodium nitroprusside and L-arginine methyl ester on rat hearts stored at 4 °C for 24 h
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Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (5): 557–564.
Published: 01 November 1998
...Oluwole S. FAGBEMI; Basil J. NORTHOVER 1. This study examined the effects of altering nitric oxide levels with sodium nitroprusside or l -arginine in rat hearts stored hypothermically. 2. Hearts were microperfused at 4 ;°C for 24 ;h with a modified Krebs–Henseleit buffer (KHB) that contained either...
Articles
Dose-Related Effect of Intravenous l-Arginine on Muscular Blood Flow of the Calf in Patients with Peripheral Vascular Disease: A H215O Positron Emission Tomography Study
Available to PurchaseSebastian M. Schellong, Rainer H. Böger, Wolfgang Burchert, Stefanie M. Bode-Böger, Andrea Galland, Jürgen C. Frölich, Heinz Hundeshagen, Klaus Alexander
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (2): 159–165.
Published: 01 August 1997
...Sebastian M. Schellong; Rainer H. Böger; Wolfgang Burchert; Stefanie M. Bode-Böger; Andrea Galland; Jürgen C. Frölich; Heinz Hundeshagen; Klaus Alexander 1. Endothelium-derived nitric oxide (NO) contributes to the regulation of vascular tone and blood pressure. Infusion of l-arginine produces...
Articles
Haemodynamic and Biochemical Responses to l-Arginine and l-Lysine Infusions in Normal Subjects: l-Arginine-Induced Vasodilatation Cannot be Explained by Non-Specific Effects of Cationic Amino Acids
Available to PurchaseR. A. Smulders, M. Aarsen, T. Teerlink, P. M. J. M. De Vries, G. J. Van Kamp, A. J. M. Donker, C. D. A. Stehouwer
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (4): 367–374.
Published: 01 April 1997
... as to whether the precursor of NO, l-arginine, is able to stimulate basal endothelial NO production. l-Arginine is known to have vasodilating effects. However, it is not clear whether l-arginine-induced vasodilatation is attributable to an increase in NO production or to other systemic effects of l-arginine. 3...
Articles
Role of Nitric Oxide towards Vasodilator Effects of Substance P and ATP in Human Forearm Vessels
Available to PurchaseMasanari Shiramoto, Tsutomu Imaizumi, Yoshitaka Hirooka, Toyonari Endo, Takashi Namba, Jun-Ichi Oyama, Kiyoshi Hironaga, Akira Takeshita
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (2): 123–131.
Published: 01 February 1997
... of acetylcholine, substance P, ATP or sodium nitroprusside into the brachial artery before and after infusion of N G -monomethyl- l -arginine (4 or 8 μmol/min for 5 min). In addition, we measured forearm blood flow while infusing substance P before and during infusion of l -arginine (10 mg/min, simultaneously...
Articles
Nitric Oxide in Streptozotocin-Induced Diabetes Mellitus in Rats
Available to PurchaseAbed Maree, Gari Peer, Adrian Iaina, Miriam Blum, Yoram Wollman, Tamara Csernihovsky, Donald S. Silverberg, Shaltiel Cabili
Journal:
Clinical Science
Clin Sci (Lond) (1996) 90 (5): 379–384.
Published: 01 May 1996
...-arginine and/or N -ω-nitro-l-arginine, a known nitric oxide synthase inhibitor in streptozotocin-induced diabetic rats. 2. Normal rats and rats drinking hypertonic glucose (10%) were used as time-controlled groups. Six weeks after administration of streptozotocin the diabetic rats had significantly higher...
Articles
l-Arginine Increases Exhaled Nitric Oxide in Normal Human Subjects
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (2): 135–139.
Published: 01 February 1995
...Sergei A. Kharitonov; Gert Lubec; Barbara Lubec; Magnus Hjelm; Peter J. Barnes 1. Endogenous nitric oxide plays an important physiological role and is synthesized by several isoforms of nitric oxide synthase from the semiessential amino acid l-arginine. Nitric oxide is detectable in the exhaled air...
Articles
l-Arginine Infusion Decreases Peripheral Arterial Resistance and Inhibits Platelet Aggregation in Healthy Subjects
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Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (3): 303–310.
Published: 01 September 1994
...S. M. Bode-Böger; R. H. Böger; A. Creutzig; D. Tsikas; F.-M. Gutzki; K. Alexander; J. C. Frölich 1. L-Arginine is the physiological precursor of nitric oxide which induces vasodilatation and inhibits platelet aggregation by the formation of cyclic GMP. 2. In the present study we investigated...
Articles
Plasma Endothelin Levels and Vascular Effects of Intravenous l-Arginine Infusion in Subjects with Uncomplicated Insulin-Dependent Diabetes Mellitus
Available to PurchaseRonald A. Smulders, Coen D. A. Stehouwer, Cornelis G. Olthof, Gerard J. Van Kamp, Tom Teerlink, Peter M. J. M. De Vries, Ab J. M. Donker
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 37–43.
Published: 01 July 1994
... to the development of microvascular complications. The endothelium plays an important role in the regulation of vascular tone. 2. To investigate the role of endothelial mediators, we measured plasma endothelin levels and studied the vascular effects of intravenous l-arginine (the precursor of NO) in 10 male type 1...
Articles
l-Arginine Reverses the Impairment of Nitric Oxide-Dependent Collateral Perfusion in Dietary-Induced Hypercholesterolaemia in the Rabbit
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Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (1): 53–59.
Published: 01 July 1994
...Michael D. Randall; Hiroshi Ujiie; Tudor M. Griffith 1. We have used an isolated, buffer-perfused, rabbit ear model of acute arterial occlusion to investigate the effects of exogenous l-arginine on the severe impairment of collateral perfusion associated with dietary-induced hypercholesterolaemia...
Articles
Nutritional Pharmacology: Effects of l-Arginine on Host Defences, Response to Trauma and Tumour Growth
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Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (2): 123–132.
Published: 01 February 1994
...J. Brittenden; S.D. Heys; J. Ross; K.G.M. Park; O. Eremin © 1994 The Biochemical Society and the Medical Research Society 1994 l-arginine immune system pharmacology Clinical Science (1994) 86, 123-132 (Printed in Great Britain) Editorial Review Nutritional pharmacology: effects of L...
Articles
Stimulation of human breast cancers by dietary l-arginine
Available to PurchaseKenneth G. M. Park, Steven D. Heys, Karen Blessing, Peter Kelly, Margaret A. McNurlan, Oleg Eremin, Peter J. Garlick
Journal:
Clinical Science
Clin Sci (Lond) (1992) 82 (4): 413–417.
Published: 01 April 1992
...Kenneth G. M. Park; Steven D. Heys; Karen Blessing; Peter Kelly; Margaret A. McNurlan; Oleg Eremin; Peter J. Garlick 1. The amino acid L-arginine has been shown to enhance immune mechanisms and inhibit tumour growth in experimental animals, but although many of the immunological effects of arginine...
Articles
Effects of l-arginine on systemic and renal haemodynamics in conscious dogs
Available to PurchaseMarohito Murakami, Hiromichi Suzuki, Atsuhiro Ichihara, Mareo Naitoh, Hidetomo Nakamoto, Takao Saruta
Journal:
Clinical Science
Clin Sci (Lond) (1991) 81 (6): 727–732.
Published: 01 December 1991
...Marohito Murakami; Hiromichi Suzuki; Atsuhiro Ichihara; Mareo Naitoh; Hidetomo Nakamoto; Takao Saruta 1. The effects of l -arginine on systemic and renal haemodynamics were investigated in conscious dogs. l -Arginine was administered intravenously at doses of 15 and 75 μmol min −1 kg −1 for 20 min...
Articles
Differential Effects of Amino Acids on the Isolated Perfused Rat Kidney
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (4): 381–386.
Published: 01 October 1990
...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The direct effects of individual amino acids, including glycine (a neutral amino acid), l-glutamic acid (an acidic amino acid), l-leucine (a neutral, branched-chain amino acid) and l-arginine (a basic amino acid), on renal function were compared...
Articles
Direct Vascular Effects in the Rat of the Vehicles Used for the Intravenous and Oral Administration of Cyclosporin A
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Journal:
Clinical Science
Clin Sci (Lond) (1990) 79 (2): 149–154.
Published: 01 August 1990
... by acetylcholine, carbamylcholine or adenosine 5′-triphosphate, by a factor of approximately 66%. 3. This reversal of relaxation was unaffected by indomethacin and did not require the presence of cyclosporin A in the vehicles, and was completely abolished by l-arginine (3 × 10 −-5 mol/l). 4. It is concluded...