... and the radioactivity of the free amino acid in the culture medium, using the formula [ 28 ] L -arginine arginase L -citrulline human breast tumour cell protein synthesis tumour growth An MCF-7 human breast tumour cell line, maintained in the Department of Surgery, University of Aberdeen...

...Friedrich MITTERMAYER; Khodadad NAMIRANIAN; Johannes PLEINER; Georg SCHALLER; Michael WOLZT Acute inflammation impairs vascular function. Based on the association between endothelial dysfunction and plasma concentrations of L -arginine and the endogenous nitric oxide synthase inhibitor ADMA...

...Jin-Gang ZHANG; Manuel GALIÑANES The role of the L -arginine/nitric oxide (NO) pathway in myocardial ischaemic/reperfusion injury remains controversial in experimental animal models. The aim of the present studies was to investigate the role of this pathway in the human myocardium. Myocardial...

...Markus P. SCHLAICH; Johannes JACOBI; Stefan JOHN; Christian DELLES; Ingrid FLEISCHMANN; Roland E. SCHMIEDER Systemic administration of L -arginine alters renal haemodynamics in humans. We examined whether L -arginine-induced vasodilation of the renal vasculature is related to an increased...

...Oranee TANGPHAO; Stephan CHALON; Heitor MORENO, JR.; Brian B. HOFFMAN; Terrence F. BLASCHKE Acute administration of L -arginine, the precursor of endothelial nitric oxide, has been shown to improve endothelial function in hypercholesterolaemic rabbits and humans. Animal studies suggest...

...Oluwole S. FAGBEMI; Basil J. NORTHOVER 1. This study examined the effects of altering nitric oxide levels with sodium nitroprusside or l -arginine in rat hearts stored hypothermically. 2. Hearts were microperfused at 4 ;°C for 24 ;h with a modified Krebs–Henseleit buffer (KHB) that contained either...

...Sebastian M. Schellong; Rainer H. Böger; Wolfgang Burchert; Stefanie M. Bode-Böger; Andrea Galland; Jürgen C. Frölich; Heinz Hundeshagen; Klaus Alexander 1. Endothelium-derived nitric oxide (NO) contributes to the regulation of vascular tone and blood pressure. Infusion of l-arginine produces...

... as to whether the precursor of NO, l-arginine, is able to stimulate basal endothelial NO production. l-Arginine is known to have vasodilating effects. However, it is not clear whether l-arginine-induced vasodilatation is attributable to an increase in NO production or to other systemic effects of l-arginine. 3...

... of acetylcholine, substance P, ATP or sodium nitroprusside into the brachial artery before and after infusion of N G -monomethyl- l -arginine (4 or 8 μmol/min for 5 min). In addition, we measured forearm blood flow while infusing substance P before and during infusion of l -arginine (10 mg/min, simultaneously...

...-arginine and/or N -ω-nitro-l-arginine, a known nitric oxide synthase inhibitor in streptozotocin-induced diabetic rats. 2. Normal rats and rats drinking hypertonic glucose (10%) were used as time-controlled groups. Six weeks after administration of streptozotocin the diabetic rats had significantly higher...

...Sergei A. Kharitonov; Gert Lubec; Barbara Lubec; Magnus Hjelm; Peter J. Barnes 1. Endogenous nitric oxide plays an important physiological role and is synthesized by several isoforms of nitric oxide synthase from the semiessential amino acid l-arginine. Nitric oxide is detectable in the exhaled air...

...S. M. Bode-Böger; R. H. Böger; A. Creutzig; D. Tsikas; F.-M. Gutzki; K. Alexander; J. C. Frölich 1. L-Arginine is the physiological precursor of nitric oxide which induces vasodilatation and inhibits platelet aggregation by the formation of cyclic GMP. 2. In the present study we investigated...

... to the development of microvascular complications. The endothelium plays an important role in the regulation of vascular tone. 2. To investigate the role of endothelial mediators, we measured plasma endothelin levels and studied the vascular effects of intravenous l-arginine (the precursor of NO) in 10 male type 1...

...Michael D. Randall; Hiroshi Ujiie; Tudor M. Griffith 1. We have used an isolated, buffer-perfused, rabbit ear model of acute arterial occlusion to investigate the effects of exogenous l-arginine on the severe impairment of collateral perfusion associated with dietary-induced hypercholesterolaemia...

...J. Brittenden; S.D. Heys; J. Ross; K.G.M. Park; O. Eremin © 1994 The Biochemical Society and the Medical Research Society 1994 l-arginine immune system pharmacology Clinical Science (1994) 86, 123-132 (Printed in Great Britain) Editorial Review Nutritional pharmacology: effects of L...

...Kenneth G. M. Park; Steven D. Heys; Karen Blessing; Peter Kelly; Margaret A. McNurlan; Oleg Eremin; Peter J. Garlick 1. The amino acid L-arginine has been shown to enhance immune mechanisms and inhibit tumour growth in experimental animals, but although many of the immunological effects of arginine...

...Marohito Murakami; Hiromichi Suzuki; Atsuhiro Ichihara; Mareo Naitoh; Hidetomo Nakamoto; Takao Saruta 1. The effects of l -arginine on systemic and renal haemodynamics were investigated in conscious dogs. l -Arginine was administered intravenously at doses of 15 and 75 μmol min −1 kg −1 for 20 min...

...A. A. El Sayed; J. Haylor; A. M. El Nahas 1. The direct effects of individual amino acids, including glycine (a neutral amino acid), l-glutamic acid (an acidic amino acid), l-leucine (a neutral, branched-chain amino acid) and l-arginine (a basic amino acid), on renal function were compared...

... by acetylcholine, carbamylcholine or adenosine 5′-triphosphate, by a factor of approximately 66%. 3. This reversal of relaxation was unaffected by indomethacin and did not require the presence of cyclosporin A in the vehicles, and was completely abolished by l-arginine (3 × 10 −-5 mol/l). 4. It is concluded...