...J. J. McNeil; A. E. Anderson; W. J. Louis 1. Blood pressure measurements were made in hypertensive subjects after single intravenous and oral doses of labetalol and subsequently during chronic administration. 2. Oral therapy can be as effective as intravenous therapy in achieving acute blood...

...I. Heck; G. Trübestein; K. O. Stumpe 1. Six weeks' treatment with labetalol (600 mg/day) significantly reduced systolic and diastolic blood pressures in 24 patients with essential hypertension. There was a small but not significant decrease in heart rate. 2. After 6 weeks of therapy mean digital...

...A. Salvetti; R. Pedrinelli; P. Sassano; F. Arzilli 1. Four different doses of labetalol (150, 300, 600 and 900 mg/day) were given for 1 week to each of four groups of patients with essential hypertension (six patients for each group). 2. Labetalol decreased mean blood pressure and heart rate...

...R. Fagard; A. Amery; T. Reybrouck; P. Lijnen; L. Billiet 1. Labetalol was administered to 18 hypertensive patients for an average duration of 2·44 weeks, with an average final daily dose of 1·65 g. 2. Labetalol decreased resting heart rate by 16% and maximal exercise heart rate by 21...

...D. Pugsley; B. Armstrong; M. Nassim; L. J. Beilin 1. Labetalol (AH 5158) is a new drug which has both α- and β-adrenoreceptor antagonist activity. Labetalol has been compared with propranolol and placebo for the treatment of mild to moderate hypertension (150/100 to 189/114 mmHg), in a double-blind...

...-exercise blood pressures. Small reductions were seen only with sustained phentolamine administration. 4. The combined effect of the two drugs appeared to be additive only at the lower doses of oxprenolol. 5. Labetalol produced significantly greater reductions in supine and standing blood pressure than...

...E. A. Rosei; P. M. Trust; J. J. Brown; R. Fraser; A. F. Lever; J. J. Morton; J. I. S. Robertson 1. Labetalol, a compound with both α- and β-adrenoreceptor-blocking actions, was given intravenously (1·5–2·0 mg/kg) in twenty recumbent hypertensive patients. 2. There was a rapid reduction in systolic...