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1-27 of 27
Keywords: leptin
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (23): 1771–1785.
Published: 14 December 2023
...William J. Kalusche; Clinton T. Case; Erin B. Taylor Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that is characterized by B- and T-lymphocyte dysfunction and altered cytokine production, including elevated levels of the adipocytokine leptin. Leptin has various...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... endothelium in young female mice protects from obesity-associated, leptin-induced reduction in endothelial function [ 63 ]. Therefore, the role of progesterone in obesity-associated hypertension risk is an area in need of further investigation. Clinical data on progesterone–hypertension associations...
Articles
Mengqi Su, Li Sun, Wenpeng Li, He Liu, Yang Liu, Ying Wei, Yue Yuan, Linqun Zheng, Shuangli Yin, Chenguang Dai, Chenyang Zhao, Zhenwei Pan, Yue Li
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1537–1553.
Published: 25 June 2020
... characteristics. According to mRNA-sequencing analysis, UA significantly decreased the expression of leptin in adipocytes, which was closely related to fatty acid metabolism and the AMPK signalling pathway, as indicated by KEGG pathway analysis. Moreover, lowering UA using benzbromarone (a uricosuric agent...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (7): 483–495.
Published: 11 December 2013
...Chiung-Zuan Chiu; Bao-Wei Wang; Kou-Gi Shyu Mechanical cyclic stretch of cardiomyocytes causes cardiac hypertrophy through cardiac-restricted gene expression. Leptin induces cardiomyocyte hypertrophy in response to myocardial stress. In the present study, we evaluated the expression of leptin under...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (1): 33–42.
Published: 13 September 2011
...Kou-Gi Shyu; Shih-Chung Chen; Bao-Wei Wang; Wen-Pin Cheng; Huei-Fong Hung Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes. Statin suppresses leptin expression in adipocytes and human...
Includes: Supplementary data
Articles
Nassira Batoul Benkalfat, Hafida Merzouk, Samira Bouanane, Sid-Ahmed Merzouk, Jérôme Bellenger, Joseph Gresti, Christian Tessier, Michel Narce
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (1): 19–28.
Published: 18 March 2011
... on adipose tissue metabolism in the offspring. Postnatal changes in serum adiponectin, leptin and TAG [triacylglycerol (triglyceride)] levels, adipose tissue TAGs, fatty acids and enzyme activities were determined in offspring of cafeteria-diet-fed dams during gestation and lactation, weaned on to standard...
Articles
Time course of changes in serum oxidant/antioxidant status in overfed obese rats and their offspring
Samira Bouanane, Nassira B. Benkalfat, Fatima-Zohra Baba Ahmed, Hafida Merzouk, Nassima S. Mokhtari, Sid-Ahmed Merzouk, Joseph Gresti, Christian Tessier, Michel Narce
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (8): 669–680.
Published: 16 March 2009
..., insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (7): 219–224.
Published: 03 September 2008
...Makrina D. Savvidou; Alexandros Sotiriadis; Christine Kaihura; Kypros H. Nicolaides; Naveed Sattar Adiponectin and leptin, two adipose-tissue-derived proteins, have been reported to be elevated in women with established PE (pre-eclampsia). The aim of the present study was to investigate whether...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (5): 381–392.
Published: 01 February 2008
... an increase in body adiposity with hyperleptinaemia. In conclusion, low protein during gestation improves BM, fat mass and growth rate in F1 rats, but has adverse effects on glucose and leptin metabolism, resulting in insulin resistance in adult F1 and F2 offspring. Low protein during lactation has adverse...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (10): 397–399.
Published: 12 October 2007
... insulin resistance leptin metabolic syndrome obesity Type 2 diabetes In the current dietary recommendations for people with Type 2 diabetes, there is flexibility in the proportion of energy derived from monounsaturated fats and carbohydrate [ 2 , 3 ]. Provided that energy intake is controlled...
Articles
Natalia Sinitskaya, Sylviane Gourmelen, Carole Schuster-Klein, Béatrice Guardiola-Lemaitre, Paul Pévet, Etienne Challet
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (10): 417–425.
Published: 12 October 2007
... index; +13 and +10% respectively; P <0.05) and abdominal fat (+70% in both HFD1 and HFD2; P <0.05), higher plasma leptin (+130 and +135% respectively; P <0.05), lower plasma adiponectin levels (−23 and −30% respectively; P <0.05) and impaired glucose tolerance. Only the HFD1 group had...
Articles
Katarzyna Krzyzanowska, Walter Krugluger, Friedrich Mittermayer, Rupa Rahman, Dominik Haider, Nadja Shnawa, Guntram Schernthaner
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (5): 605–609.
Published: 11 April 2006
..., visfatin, leptin and metabolic parameters were investigated twice during pregnancy (28–30 and 38–40 weeks of gestation) and 2 weeks after delivery. In the cross-sectional analysis, median visfatin levels were significantly elevated in women with GDM [64.0 (interquartile range, 50.9–74.8) ng/ml] compared...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2006) 110 (2): 143–152.
Published: 17 January 2006
... physiological processes and participates in disease. Adipose tissue secretes factors that exert local and systemic effects. Leptin, pro-inflammatory cytokines, resistin and proteins involved in haemodynamic regulation and coagulation are increased in obesity while adiponectin is reduced. The production...
Articles
Eric DOUCET, Pascal IMBEAULT, Sylvie ST-PIERRE, Natalie ALMÉRAS, Pascale MAURIÈGE, Jean-Pierre DESPRÉS, Claude BOUCHARD, Angelo TREMBLAY
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (1): 89–95.
Published: 01 July 2003
... The Biochemical Society 2003 caloric restriction exercise leptin obesity Clinical Science (2003) 105, 89 95 (Printed in Great Britain) 89 Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men Eric DOUCET*, Pascal IMBEAULT*, Sylvie ST-PIERRE*, Natalie...
Articles
Fiona E. ARROWSMITH, Julie WARD, Kieron ROONEY, Adamandia D. KRIKETOS, Louise A. BAUR, Campbell H. THOMPSON
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (4): 391–396.
Published: 30 August 2002
..., Level 3, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia (e-mail [email protected] ). 5 3 2002 24 5 2002 8 7 2002 The Biochemical Society and the Medical Research Society © 2002 2002 insulin resistance leptin near-IR spectroscopy...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (5): 493–498.
Published: 29 March 2001
...Kevin EVANS; Mo L. CLARK; Keith N. FRAYN Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (2): 145–150.
Published: 20 December 2000
...Hiroshi HIROSE; Ikuo SAITO; Toshihide KAWAI; Minako TSUJIOKA; Hiroshi KAWABE; Takao SARUTA We and others have reported that serum leptin levels are positively correlated with body mass index (BMI), blood pressure and heart rate (HR) in cross-sectional clinical studies. However, only a few...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 99 (6): 527–534.
Published: 15 November 2000
...Jens H. HENRIKSEN; Jens J. HOLST; Søren MØLLER; Ulrik B. ANDERSEN; Flemming BENDTSEN; Gorm JENSEN Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (3): 363–368.
Published: 06 August 1999
...Daniel TETA; Alan BEVINGTON; Jeremy BROWN; David THROSSELL; Kevin P. G. HARRIS; John WALLS Marked hyperleptinaemia and metabolic acidosis are common findings in patients with chronic renal failure. In animal models, both leptin administration and acidosis reduce food intake. However, leptin causes...
Articles
Eric RAYNAUD, Jean-Frédéric BRUN, Antonia PEREZ-MARTIN, Colette SAGNES, Anne-Marie BOULARAN, Christine FEDOU, Jacques MERCIER
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (4): 343–348.
Published: 01 April 1999
...Eric RAYNAUD; Jean-Frédéric BRUN; Antonia PEREZ-MARTIN; Colette SAGNES; Anne-Marie BOULARAN; Christine FEDOU; Jacques MERCIER Leptin is an adipocyte-derived signalling molecule which plays a key role in the regulation of body weight and energy expenditure. Since its involvement in human eating...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (3): 307–312.
Published: 01 March 1999
...Simon DRYDEN; Peter KING; Lucy PICKAVANCE; Patrick DOYLE; Gareth WILLIAMS Leptin inhibits feeding and decreases body weight. It may act partly by inhibiting hypothalamic neurons that express neuropeptide Y, a powerful inducer of feeding and obesity. These neuropeptide Y neurons express the Ob-Rb...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (6): 633–636.
Published: 01 June 1998
...Hiroshi Hirose; Ikuo Saito; Toshihide Kawai; Keiko Nakamura; Hiroshi Maruyama; Takao Saruta 1. The obese gene product leptin, secreted exclusively from adipocytes, was discovered to serve as a satiety factor and to play an important role in regulating body weight. In adults, the serum leptin level...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 94 (5): 479–483.
Published: 01 May 1998
...Anne Ballinger; Paul Kelly; Elizabeth Hallyburton; Rachel Besser; Michael Farthing 1. Leptin inhibits food intake and is an important regulator of long-term energy balance. In rodents, plasma concentrations of leptin are increased by administration of interleukin-1 and tumour necrosis factor...
Articles
Melina S. Solin, Madeleine J. Ball, Iain Robertson, Andrea De Silva, Julie A. Pasco, Mark A. Kotowicz, Geoff C. Nicholson, Greg R. Collier
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (6): 581–584.
Published: 01 December 1997
...Melina S. Solin; Madeleine J. Ball; Iain Robertson; Andrea De Silva; Julie A. Pasco; Mark A. Kotowicz; Geoff C. Nicholson; Greg R. Collier 1. In this study we investigated the relationship between serum leptin levels and body fat distribution in a random sample of women of widely ranging age...
Articles
Jean Paul F.H.A. Simons, Annemie M.W.J. Schols, L. Arthur Campfield, Emiel F.M. Wouters, Wim H. Saris
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (3): 273–277.
Published: 01 September 1997
...Jean Paul F.H.A. Simons; Annemie M.W.J. Schols; L. Arthur Campfield; Emiel F.M. Wouters; Wim H. Saris 1. Adipocyte-derived leptin is postulated to represent the afferent hormonal signal to the hypothalamus in a feedback mechanism that regulates fat mass. In this proposed feedback mechanism...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (2): 113–117.
Published: 01 August 1997
...Rebecca J. Stratton; Odile Dewit; Elaine Crowe; Graham Jennings; Richard N. Villar; Marinos Elia 1. This study aimed to investigate the possible role of leptin in post-traumatic anorexia by making pre- and post-operative (0–8 days) measurements of circulating leptin concentrations in six patients...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (6): 573–578.
Published: 01 June 1997
...Leila Karhunen; Steven Haffner; Raimo Lappalainen; ANU Turpeinen; Heikki Miettinen; Matti Uusitupa 1. Leptin is generally thought to play a key role in the regulation of eating. However, its real role in human eating behaviour is still poorly known. Therefore, the role of leptin in the regulation...