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Keywords: leptin
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Clin Sci (Lond) (2021) 135 (12): 1523–1544.
Published: 23 June 2021
... © 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2021 heart failure hypertension leptin Obesity preeclampsia Women's Health Both adolescent and adult obesity prevalence has reached proportions of >30% in the United States...
Clin Sci (Lond) (2020) 134 (12): 1537–1553.
Published: 25 June 2020
... characteristics. According to mRNA-sequencing analysis, UA significantly decreased the expression of leptin in adipocytes, which was closely related to fatty acid metabolism and the AMPK signalling pathway, as indicated by KEGG pathway analysis. Moreover, lowering UA using benzbromarone (a uricosuric agent...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (7): 483–495.
Published: 11 December 2013
...Chiung-Zuan Chiu; Bao-Wei Wang; Kou-Gi Shyu Mechanical cyclic stretch of cardiomyocytes causes cardiac hypertrophy through cardiac-restricted gene expression. Leptin induces cardiomyocyte hypertrophy in response to myocardial stress. In the present study, we evaluated the expression of leptin under...
Clin Sci (Lond) (2012) 122 (1): 33–42.
Published: 13 September 2011
...Kou-Gi Shyu; Shih-Chung Chen; Bao-Wei Wang; Wen-Pin Cheng; Huei-Fong Hung Leptin contributes to the pathogenesis of atherosclerosis. Ang II (angiotensin II), a proatherogenic cytokine, increases leptin synthesis in cultured adipocytes. Statin suppresses leptin expression in adipocytes and human...
Includes: Supplementary data
Clin Sci (Lond) (2011) 121 (1): 19–28.
Published: 18 March 2011
... on adipose tissue metabolism in the offspring. Postnatal changes in serum adiponectin, leptin and TAG [triacylglycerol (triglyceride)] levels, adipose tissue TAGs, fatty acids and enzyme activities were determined in offspring of cafeteria-diet-fed dams during gestation and lactation, weaned on to standard...
Clin Sci (Lond) (2009) 116 (8): 669–680.
Published: 16 March 2009
..., insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body...
Clin Sci (Lond) (2008) 115 (7): 219–224.
Published: 03 September 2008
...Makrina D. Savvidou; Alexandros Sotiriadis; Christine Kaihura; Kypros H. Nicolaides; Naveed Sattar Adiponectin and leptin, two adipose-tissue-derived proteins, have been reported to be elevated in women with established PE (pre-eclampsia). The aim of the present study was to investigate whether...
Clin Sci (Lond) (2008) 114 (5): 381–392.
Published: 01 February 2008
... an increase in body adiposity with hyperleptinaemia. In conclusion, low protein during gestation improves BM, fat mass and growth rate in F1 rats, but has adverse effects on glucose and leptin metabolism, resulting in insulin resistance in adult F1 and F2 offspring. Low protein during lactation has adverse...
Clin Sci (Lond) (2007) 113 (10): 397–399.
Published: 12 October 2007
...: Dr Marie C. Guldstrand (email marie.guldstrand@ds.se ). 30 7 2007 22 8 2007 23 8 2007 23 8 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 adiponectin high-fat diet insulin resistance leptin metabolic syndrome obesity Type 2 diabetes...
Clin Sci (Lond) (2007) 113 (10): 417–425.
Published: 12 October 2007
... index; +13 and +10% respectively; P <0.05) and abdominal fat (+70% in both HFD1 and HFD2; P <0.05), higher plasma leptin (+130 and +135% respectively; P <0.05), lower plasma adiponectin levels (−23 and −30% respectively; P <0.05) and impaired glucose tolerance. Only the HFD1 group had...
Clin Sci (Lond) (2006) 110 (5): 605–609.
Published: 11 April 2006
..., visfatin, leptin and metabolic parameters were investigated twice during pregnancy (28–30 and 38–40 weeks of gestation) and 2 weeks after delivery. In the cross-sectional analysis, median visfatin levels were significantly elevated in women with GDM [64.0 (interquartile range, 50.9–74.8) ng/ml] compared...
Clin Sci (Lond) (2006) 110 (2): 143–152.
Published: 17 January 2006
... physiological processes and participates in disease. Adipose tissue secretes factors that exert local and systemic effects. Leptin, pro-inflammatory cytokines, resistin and proteins involved in haemodynamic regulation and coagulation are increased in obesity while adiponectin is reduced. The production...
Clin Sci (Lond) (2003) 105 (1): 89–95.
Published: 01 July 2003
... The Biochemical Society 2003 caloric restriction exercise leptin obesity Clinical Science (2003) 105, 89 95 (Printed in Great Britain) 89 Greater than predicted decrease in energy expenditure during exercise after body weight loss in obese men Eric DOUCET*, Pascal IMBEAULT*, Sylvie ST-PIERRE*, Natalie...
Clin Sci (Lond) (2002) 103 (4): 391–396.
Published: 30 August 2002
..., Level 3, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia (e-mail campbell.thompson@fmc.sa.gov.au ). 5 3 2002 24 5 2002 8 7 2002 The Biochemical Society and the Medical Research Society © 2002 2002 insulin resistance leptin near-IR spectroscopy...
Clin Sci (Lond) (2001) 100 (5): 493–498.
Published: 29 March 2001
...Kevin EVANS; Mo L. CLARK; Keith N. FRAYN Leptin is secreted by adipocytes and plays a role in the regulation of food intake. However, the regulation of leptin production by adipose tissue is unclear. We have investigated whether a mixed meal or a high-fat load given orally, or a pure fat load given...
Clin Sci (Lond) (2001) 100 (2): 145–150.
Published: 20 December 2000
...Hiroshi HIROSE; Ikuo SAITO; Toshihide KAWAI; Minako TSUJIOKA; Hiroshi KAWABE; Takao SARUTA We and others have reported that serum leptin levels are positively correlated with body mass index (BMI), blood pressure and heart rate (HR) in cross-sectional clinical studies. However, only a few...
Clin Sci (Lond) (2000) 99 (6): 527–534.
Published: 15 November 2000
...Jens H. HENRIKSEN; Jens J. HOLST; Søren MØLLER; Ulrik B. ANDERSEN; Flemming BENDTSEN; Gorm JENSEN Leptin, a peptide hormone produced mainly in fat cells, appears to be important for the regulation of metabolism, insulin secretion/sensitivity and body weight. Recently, elevated plasma leptin levels...
Clin Sci (Lond) (1999) 97 (3): 363–368.
Published: 06 August 1999
...Daniel TETA; Alan BEVINGTON; Jeremy BROWN; David THROSSELL; Kevin P. G. HARRIS; John WALLS Marked hyperleptinaemia and metabolic acidosis are common findings in patients with chronic renal failure. In animal models, both leptin administration and acidosis reduce food intake. However, leptin causes...
Clin Sci (Lond) (1999) 96 (4): 343–348.
Published: 01 April 1999
...Eric RAYNAUD; Jean-Frédéric BRUN; Antonia PEREZ-MARTIN; Colette SAGNES; Anne-Marie BOULARAN; Christine FEDOU; Jacques MERCIER Leptin is an adipocyte-derived signalling molecule which plays a key role in the regulation of body weight and energy expenditure. Since its involvement in human eating...
Clin Sci (Lond) (1999) 96 (3): 307–312.
Published: 01 March 1999
...Simon DRYDEN; Peter KING; Lucy PICKAVANCE; Patrick DOYLE; Gareth WILLIAMS Leptin inhibits feeding and decreases body weight. It may act partly by inhibiting hypothalamic neurons that express neuropeptide Y, a powerful inducer of feeding and obesity. These neuropeptide Y neurons express the Ob-Rb...
Clin Sci (Lond) (1998) 94 (6): 633–636.
Published: 01 June 1998
...Hiroshi Hirose; Ikuo Saito; Toshihide Kawai; Keiko Nakamura; Hiroshi Maruyama; Takao Saruta 1. The obese gene product leptin, secreted exclusively from adipocytes, was discovered to serve as a satiety factor and to play an important role in regulating body weight. In adults, the serum leptin level...
Clin Sci (Lond) (1998) 94 (5): 479–483.
Published: 01 May 1998
...Anne Ballinger; Paul Kelly; Elizabeth Hallyburton; Rachel Besser; Michael Farthing 1. Leptin inhibits food intake and is an important regulator of long-term energy balance. In rodents, plasma concentrations of leptin are increased by administration of interleukin-1 and tumour necrosis factor...
Clin Sci (Lond) (1997) 93 (6): 581–584.
Published: 01 December 1997
...Melina S. Solin; Madeleine J. Ball; Iain Robertson; Andrea De Silva; Julie A. Pasco; Mark A. Kotowicz; Geoff C. Nicholson; Greg R. Collier 1. In this study we investigated the relationship between serum leptin levels and body fat distribution in a random sample of women of widely ranging age...
Clin Sci (Lond) (1997) 93 (3): 273–277.
Published: 01 September 1997
...Jean Paul F.H.A. Simons; Annemie M.W.J. Schols; L. Arthur Campfield; Emiel F.M. Wouters; Wim H. Saris 1. Adipocyte-derived leptin is postulated to represent the afferent hormonal signal to the hypothalamus in a feedback mechanism that regulates fat mass. In this proposed feedback mechanism...
Clin Sci (Lond) (1997) 93 (2): 113–117.
Published: 01 August 1997
...Rebecca J. Stratton; Odile Dewit; Elaine Crowe; Graham Jennings; Richard N. Villar; Marinos Elia 1. This study aimed to investigate the possible role of leptin in post-traumatic anorexia by making pre- and post-operative (0–8 days) measurements of circulating leptin concentrations in six patients...
Clin Sci (Lond) (1997) 92 (6): 573–578.
Published: 01 June 1997
...Leila Karhunen; Steven Haffner; Raimo Lappalainen; ANU Turpeinen; Heikki Miettinen; Matti Uusitupa 1. Leptin is generally thought to play a key role in the regulation of eating. However, its real role in human eating behaviour is still poorly known. Therefore, the role of leptin in the regulation...