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Keywords: leucine
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Clin Sci (Lond) (1998) 95 (6): 725–733.
Published: 01 December 1998
... synthesis and proteolysis to protein feeding by means of [1– 13 C]leucine turnover and balance studies. 2. Twenty-five healthy adults were infused intravenously with l -[1- 13 C]leucine continuously for 9 h. This was started in the postabsorptive state (PA, 3 h) and followed by low-protein feeding (LP, 3 h...
Clin Sci (Lond) (1995) 88 (6): 597–606.
Published: 01 June 1995
...D. Joe Millward; Paul J. Pacy diurnal cycling fasting feeding indispensable amino acid requirements leucine nitrogen balance protein turnover stable isotopes Clinical Science (1995) 88, 5 9 7 4 6 (Printed in Great Britain) 597 Editorial Review Postprandial protein utilization...
Clin Sci (Lond) (1994) 86 (3): 339–345.
Published: 01 March 1994
...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...
Clin Sci (Lond) (1994) 86 (1): 91–102.
Published: 01 January 1994
..., after 12 days of adaptation to diets containing 0.36 +0.01, 0.77 + 0.03, 1.59 +0.08 and 2.31 +0.65 g of protein day −1 kg −1 . N losses were determined from measured urinary N excretion corrected for changes in the body urea pool, and estimated faecal and miscellaneous losses. [ 13 C] Leucine and [ 2 H...
Clin Sci (Lond) (1993) 84 (2): 177–183.
Published: 01 February 1993
... dose formulae when leucine is the tracer, suggesting that a flooding dose of leucine exerts a stimulatory effect on the rate of protein synthesis, but that the increase is not as great as the increase in the intracellular concentration of leucine. 4. The precision of the formula for the calculation...
Clin Sci (Lond) (1991) 81 (s25): 557–564.
Published: 01 October 1991
...M. A. McNurlan; P. Essen; S. D. Heys; V. Buchan; P. J. Garlick; J. Wernerman 1. The rate of protein synthesis in quadriceps muscle of healthy subjects estimated from the incorporation of l -[1- 13 C]leucine given by continuous infusion was 1.1%/day. The estimate of protein synthesis from...
Clin Sci (Lond) (1991) 80 (4): 345–352.
Published: 01 April 1991
... the previously observed increase in protein synthesis on insulin withdrawal in insulin-dependent (type 1) diabetic patients seen when employing the [ 13 C]leucine technique could be corroborated by using [ 2 H 5 ]phenylalanine. 2. Whole-body protein turnover was measured by both the [ 2 H 5 ]phenylalanine...
Clin Sci (Lond) (1990) 79 (5): 457–466.
Published: 01 November 1990
...Rita J. Louard; Eugene J. Barrett; Robert A. Gelfand 1. Using the forearm balance method, together with systemic infusions of l-[ ring -2,6- 3 H]phenylalanine and l-[1- 14 C]leucine, we examined the effects of infused branched-chain amino acids on whole-body and skeletal muscle amino acid kinetics...
Clin Sci (Lond) (1989) 77 (3): 329–336.
Published: 01 September 1989
... with the tracer to minimize differences in isotopic enrichment of the free amino acid in plasma and tissue compartments. This approach has been investigated in human muscle by taking biopsies from postabsorptive male volunteers given [1- 13 C]leucine. 2. Intravenous injection of 4 g of unlabelled leucine resulted...
Clin Sci (Lond) (1989) 76 (4): 447–454.
Published: 01 April 1989
...W. M. Bennet; A. A. Connacher; C. M. Scrimgeour; K. Smith; M. J. Rennie 1. Anterior tibial muscle protein synthesis in seven healthy postabsorptive men was determined from increases in muscle protein bound leucine enrichment during a primed continuous infusion of l -[1 −13 C]leucine. Biopsies were...
Clin Sci (Lond) (1988) 74 (1): 41–48.
Published: 01 January 1988
...A. M. Umpleby; D. Chubb; M. A. Boroujerdi; P. H. Sonksen 1. The effect of an infusion of sodium β-hydroxybutyrate on leucine and alanine metabolism was investigated in dogs starved for 12 h. To determine whether the metabolic changes produced by this infusion were due to the resultant alkalaemia...
Clin Sci (Lond) (1985) 68 (3): 271–282.
Published: 01 March 1985
... 1984 5 9 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 alanine amino acid aspartate glutamate glutamine glycine leucine lysine man 15 N nitrogen turnover protein absorption protein synthesis wheat whole body yeast Clinical Science (1985...
Clin Sci (Lond) (1984) 66 (2): 155–164.
Published: 01 February 1984
...B. De Benoist; Y. Abdulrazzak; O. G. Brooke; D. Halliday; D. J. Millward 1. The measurement of whole body protein turnover in the preterm infant has been investigated with an intragastric infusion of L [1- 13 C]-leucine and with sampling of the urinary leucine pool. 2. Measurements have been made...
Clin Sci (Lond) (1983) 65 (5): 491–498.
Published: 01 November 1983
...Ljusk Siw Eriksson; Lars Hagenfeldt; Philip Felig; John Wahren 1. The influence on leucine disposal of physiological alterations in plasma insulin concentrations was examined in three groups of healthy male subjects, six in each group. After an overnight fast the subjects received an intravenous...
Clin Sci (Lond) (1983) 65 (5): 499–505.
Published: 01 November 1983
... appearance, oxidation and incorporation into protein were estimated with two different isotopically labelled amino acids: l -[1- 14 C]leucine and l -[U- 14 C]tyrosine. 3. A positive correlation was obtained between whole body amino acid appearance, oxidation and incorporation into protein with the two...
Clin Sci (Lond) (1983) 64 (5): 517–526.
Published: 01 May 1983
...Marinos Elia; Geoffrey Livesey 1. The effects of ingested grilled beef steak (250 g raw weight of lean meat) and infusion of leucine (3.8 g) on human forelimb metabolism were studied by monitoring the concentrations of various metabolites in arterial (A) and venous (V) blood of four overnight...
Clin Sci (Lond) (1983) 64 (2): 231–233.
Published: 01 February 1983
... © 1983 The Biochemical Society and the Medical Research Society 1983 carbon dioxide [ 14 C]bicarbonate leucine oxidation protein turnover Clinical Science (1983) 64,23 1-233 SHORT COMMUNICATION 23 1 Recovery of infused [14C]bicarbonate as respiratory 14C02 in man GRAEME A. CLUGSTON...
Clin Sci (Lond) (1982) 62 (3): 285–293.
Published: 01 March 1982
... similar in patients and control subjects. During infusion the concentrations of α-oxoisocaproate rose to 90–130 μmol/l; they were 20–35% lower in the patients. Arterial leucine concentration increased in both groups to 250–300 μmol/l. Valine and isoleucine concentrations decreased (50–60%) as did...
Clin Sci (Lond) (1981) 61 (s7): 121s–123s.
Published: 01 December 1981
... rats (SHR) and stroke-prone SHR (SHRSP) and compared with that in normotensive Wistar—Kyoto (WKY) rats. 2. The growth rate of SMC from SHR and SHRSP at the age of 2.5–11 months was greater than that of SMC from WKY rats even after repeated passages. 3. [ 3 H]Thymidine and [ 14 C]leucine incorporation...
Clin Sci (Lond) (1981) 61 (4): 451–455.
Published: 01 October 1981
... nervous system of adult rats. 2. 3-Methylbutanal was found to be a normal constituent of rat plasma and increased two to five times when leucine comprised 5% of the diet. Neomycin in the diet prevented the leucine-induced rise in plasma 3-methylbutanal. When this was injected at a dose of 120 mg/kg...
Clin Sci (Lond) (1981) 60 (3): 319–326.
Published: 01 March 1981
... rectus abdominus muscle. The half-life of human skeletal muscle protein in vitro was estimated to be 20 days when calculated from the rate of tyrosine release. 3. The addition of leucine to the incubation medium decreased the rate of protein degradation, which was further decreased by the addition...
Clin Sci (Lond) (1981) 60 (1): 95–100.
Published: 01 January 1981
...S. Eriksson; L. Hagenfeldt; J. Wahren 1., Intravenous infusions of l-valine (600 μmol/min), l-isoleucine (150 μmol/min), l-leucine (300 μmol/min) and a mixture of the three branched-chain amino acids (70% l-leucine, 20% l-valine, 10% l-isoleucine; 270 μmol/min) were given to four groups of healthy...
Clin Sci (Lond) (1980) 59 (4): 275–283.
Published: 01 October 1980
...M. Elia; Rose Farrell; Vera Ilic; R. Smith; D. H. Williamson 1. To investigate the effects of starvation, elective surgery, accidental injury and other clinical conditions on the metabolism of branched-chain amino acids in man, we have measured the basal concentration of leucine and the removal...
Clin Sci (Lond) (1980) 59 (3): 173–181.
Published: 01 September 1980
...L. Hagenfeldt; S. Eriksson; J. Wahren 1. l -Leucine was given to healthy, post-absorptive subjects as a continuous intravenous infusion (300 μmol/min) during 2 1/2 h. Arterial blood concentrations and regional exchange of amino acids were measured across the splanchnic region, the brain and a leg...
Clin Sci (Lond) (1979) 57 (3): 281–283.
Published: 01 September 1979
...M. Taruvinga; A. A. Jackson; M. H. N. Golden 1. Whole-body protein turnover was measured in rats by constant infusion of 15 N-labelled glycine, aspartate, valine and leucine and measuring the enrichment of hepatic and renal urea and ammonia nitrogen. 2. The values obtained with [ 15 N]glycine were...
Clin Sci Mol Med (1978) 54 (2): 205–207.
Published: 01 February 1978
...J. A. Nicholson; T. J. Peters 1. The subcellular distribution of peptidase activities in the normal human jejunum against glycine and leucine homopeptides has been investigated with an analytical fractionation technique. 2. An 8000 g -min supernatant was prepared from homogenates of Crosby capsule...
Clin Sci Mol Med (1977) 53 (3): 277–288.
Published: 01 September 1977
...M. H. N. Golden; J. C. Waterlow 1. Total body protein turnover was studied in six elderly patients. 2. During the study they were fed by continuous infusion of a liquid formula through a nasogastric tube. l-[1- 14 C]Leucine and [ 15 N]glycine were infused at a constant rate for 30 h. The labelled...
Clin Sci (1972) 42 (2): 139–143.
Published: 01 February 1972
...W. W. C. Read; D. S. McLaren; Marie Tchalian 1. l-Valine, l-leucine and l-isoleucine containing 15 N were prepared, purified, and fed to marasmic and recovered infants. The excretion of total 15 N and [ 15 N]urea in the urine was followed for 72 h. 2. 15 N excreted from isoleucine was about 90...