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Vinicius Leonardo Sousa Diniz, Anuska Marcelino Alvares-Saraiva, Tamires Duarte Afonso Serdan, Laiane Cristina dos Santos-Oliveira, Vinicius Cruzat, Tiago Bertola Lobato, Richelieau Manoel, Amanda Lins Alecrim, Otavio Augusto Machado, Sandro M. Hirabara, Laureane Nunes Masi, Tania Cristina Pithon-Curi, Rui Curi, Renata Gorjão, Philip Newsholme
Clin Sci (Lond) (2023) 137 (10): 807–821.
Published: 23 May 2023
... 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 Antibody production B Cell Glucose Glutamine Immunometabolism Leucocyte Lymphocytes are produced in bone marrow with maturation in the thymus for T (thymus-derived) cells...
Clin Sci (Lond) (2013) 125 (5): 247–255.
Published: 10 May 2013
... (acetylcholine); leucocyte activation, by ex vivo measurement of plasma MPO (myeloperoxidase) levels, adherent leucocyte numbers and whole blood transit time through microchannels; and oxidative stress, by determining plasma levels of d-ROMs (derivatives of reactive oxygen metabolites). Effects of the CCBs on NF...
Marcello Rattazzi, Sabina Villalta, Silvia Galliazzo, Laura Del Pup, Alessandra Sponchiado, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Elena Seganfreddo, Valeria Pagliara, Elena Callegari, Massimo Puato, Livio Caberlotto, Gianluigi Scannapieco, Gian Paolo Fadini, Paolo Pauletto
Clin Sci (Lond) (2013) 125 (4): 211–222.
Published: 01 May 2013
... and circulating leucocytes in determining VTE risk. We enrolled 240 patients who were referred to the Thrombosis Unit of the Cà Foncello Hospital in Treviso between October 2010 and April 2012 and had at least one objectively diagnosed episode of DVT (deep venous thrombosis) and/or PE (pulmonary...
Includes: Supplementary data
Ellen H. A. M. Elsenberg, Dik Versteeg, Jan-Willem Sels, Pieter-Jan J. Vlaar, Monique G. G. Hobbelink, Maarten-Jan M. Cramer, Dominique P. V. de Kleijn, René A. Tio, Bart J. G. L. de Smet, Pieter A. Doevendans, Imo E. Hoefer, Gerard Pasterkamp
Clin Sci (Lond) (2012) 122 (11): 527–533.
Published: 10 February 2012
... inflammatory responses are important in the progression of atherosclerosis. We previously showed that TLR-dependent leucocyte responsiveness is acutely attenuated following percutaneous coronary intervention or vascular surgery. Furthermore, cytokine release following whole-blood TLR-2 and TLR-4 stimulation...
Clin Sci (Lond) (2011) 121 (7): 285–296.
Published: 07 June 2011
... obstruction incomplete airflow reversibility leucocyte pulmonary inflammation severe asthma Asthma is traditionally thought of as an inflammatory disease characterized by reversible airflow obstruction. Most patients demonstrate complete airflow reversibility, yet a small subset display FAO (fixed...
Gjin Ndrepepa, Siegmund Braun, Raisuke Iijima, Dritan Keta, Robert A. Byrne, Stefanie Schulz, Julinda Mehilli, Albert Schömig, Adnan Kastrati
Clin Sci (Lond) (2009) 116 (8): 651–658.
Published: 16 March 2009
...Gjin Ndrepepa; Siegmund Braun; Raisuke Iijima; Dritan Keta; Robert A. Byrne; Stefanie Schulz; Julinda Mehilli; Albert Schömig; Adnan Kastrati Although an association between elevated leucocyte count and mortality in patients with ACS (acute coronary syndromes) has been established, the independence...
Thais Martins de Lima, Renata Gorjão, Elaine Hatanaka, Maria Fernanda Cury-Boaventura, Erica Paula Portioli Silva, Joaquim Procopio, Rui Curi
Clin Sci (Lond) (2007) 113 (2): 65–77.
Published: 13 June 2007
...Thais Martins de Lima; Renata Gorjão; Elaine Hatanaka; Maria Fernanda Cury-Boaventura; Erica Paula Portioli Silva; Joaquim Procopio; Rui Curi Fatty acids (FAs) have been shown to alter leucocyte function and thus to modulate inflammatory and immune responses. In this review, the effects of FAs...
Clin Sci (Lond) (2003) 105 (1): 39–44.
Published: 01 July 2003
...Tomonari AKATSU; Motoyuki NAKAMURA; Mamoru SATOH; Katsuhiko HIRAMORI Correspondence: Dr Tomonari Akatsu (e-mail email@example.com ). 20 12 2002 26 2 2003 26 2 2003 © 2003 The Biochemical Society 2003 acute myocardial infarction leucocyte tumour necrosis...
Clin Sci (Lond) (2003) 105 (1): 21–28.
Published: 01 July 2003
...Thomas A. HEMING; Nataliya N. BULAYEVA; Akhil BIDANI Correspondence: Dr Thomas A. Heming (e-mail firstname.lastname@example.org ). 3 1 2003 12 2 2003 20 2 2003 20 2 2003 © 2003 The Biochemical Society 2003 Ca2+ homoeostasis intracellular acidbase status leucocyte...
Thomas A. HEMING, Sanat K. DAVÉ, Divina M. TUAZON, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Clin Sci (Lond) (2001) 101 (3): 267–274.
Published: 03 August 2001
..., TX 77555–0876, U.S.A. (e-mail email@example.com ). 20 4 2001 18 5 2001 The Biochemical Society and the Medical Research Society © 2001 2001 acidbase cytokine endotoxin leucocyte tumour necrosis factor- 267Clinical Science (2001) 101, 267 274 (Printed in Great Britain...
Clin Sci (Lond) (1993) 85 (1): 63–70.
Published: 01 July 1993
... metabolism may be involved in the systemic vasodilatation of normal pregnancy or pregnancy-induced hypertension, we studied platelet-activating factor and eicosanoid synthesis in isolated leucocytes obtained from pregnant women before and after delivery compared with age-matched non-pregnant control subjects...
Clin Sci (Lond) (1993) 85 (1): 27–31.
Published: 01 July 1993
..., and partially digested. Glomerular leucocytes were labelled with a mouse monoclonal antibody against leucocyte common antigen followed by a fluorescein-labelled anti-mouse immunoglobulin to allow counting. 2. In a further group of animals 24 h albumin excretion and glomerular size were measured 2 weeks after...
Clin Sci (Lond) (1992) 83 (2): 221–226.
Published: 01 August 1992
...S. M. Greenfield; A. Hamblin; N. A. Punchard; R. P. H. Thompson 1. The expression of leucocyte antigens CD11/CD18 and complement receptor 1 was studied on the circulating leucocytes of 13 patients with inflammatory bowel disease and 13 age- and sex-matched healthy control subjects. 2. Monoclonal...
C. R. K. Dudley, D. J. Taylor, L. L. Ng, G. J. Kemp, P. J. Ratcliffe, G. K. Radda, J. G. G. Ledingham
Clin Sci (Lond) (1990) 79 (5): 491–497.
Published: 01 November 1990
...C. R. K. Dudley; D. J. Taylor; L. L. Ng; G. J. Kemp; P. J. Ratcliffe; G. K. Radda; J. G. G. Ledingham 1. Exercise-induced pH changes in skeletal muscle were studied in a group of eight subjects with essential hypertension by using 31 P n.m.r. spectroscopy. 2. Leucocyte Na + /H + antiport activity...
Clin Sci (Lond) (1989) 77 (2): 189–194.
Published: 01 August 1989
... trimester. 2. EDLI, which was undetectable in serum from nonpregnant women, was present in NTP and PIH and was significantly higher in PIH. EDLI correlated with gestational age in NTP, but not in PIH. 3. Ouabain-sensitive Na + transport was estimated in normal peripheral blood leucocytes after incubation...
Clin Sci (Lond) (1989) 76 (2): 199–203.
Published: 01 February 1989
...R. Seon; T. Forrester 1. One hundred and five primigravidae were followed sequentially at 4-weekly intervals starting at gestational week 31. They were seen again at 6 weeks post partum . 2. At each visit measurements were made of blood pressure as well as of leucocyte and erythrocyte sodium...
Clin Sci (Lond) (1988) 75 (6): 577–579.
Published: 01 December 1988
... < 0.025). 2. The venous cord serum inhibited the ouabain-sensitive sodium efflux rate constant of a normal mixed leucocyte population when compared with the effect of arterial cord serum ( P < 0.005). 3. It is suggested that the placenta may be involved in the production or metabolism of neonatal EDLI...
Clin Sci (Lond) (1987) 73 (3): 291–297.
Published: 01 September 1987
... disappeared after delivery. 2. Cord serum inhibited the total sodium efflux rate constant of a mixed leucocyte preparation when compared with the effect of control serum. This inhibition resulted from a depression of the ouabain-sensitive (sodium pump) component of the rate constant. 3. An ultrafiltrate...
Clin Sci (Lond) (1985) 68 (2): 239–241.
Published: 01 February 1985
...H. H. Gray; L. Poston; V. E. Johnson; P. J. Hilton 1. Sodium efflux rate constants and intracellular sodium were measured in leucocytes from healthy volunteers in the presence and absence of the calcium antagonist verapamil hydrochloride. 2. Verapamil stimulated sodium pump activity and this effect...
Clin Sci (Lond) (1985) 68 (1): 89–91.
Published: 01 January 1985
...Valerie E. Johnson; P. J. Hilton 1. Frusemide-sensitive sodium and potassium transport by normal human leucocytes has been studied in vitro by both isotopic and net flux techniques. 2. In physiological media the leucocyte exhibits a frusemide-sensitive influx of sodium and potassium of equal...
Clin Sci (Lond) (1984) 66 (6): 741–744.
Published: 01 June 1984
...R. B. Sewell; Lucilla Poston; S. P. Wilkinson; Roger Williams 1. Leucocyte sodium efflux was measured in control leucocytes pre-incubated for 90 min with serum from patients with advanced liver cirrhosis. 2. Serum from patients with advanced alcoholic liver cirrhosis was inhibitory to sodium...
Clin Sci (Lond) (1982) 63 (3): 243–249.
Published: 01 September 1982
...L. Poston; S. Wilkinson; R. B. Sewell; R. Williams 1. Leucocyte sodium transport was investigated as a possible assay for the small molecular weight natriuretic material isolated from the urine of normal subjects who had undergone volume expansion by saline infusion. 2. This fraction (fraction four...
Clin Sci (Lond) (1982) 62 (2): 193–201.
Published: 01 February 1982
...J. J. Hopwood; Vivienne Muller 1. Iduronosyl anhydro[1- 3 H]mannitol 6-sulphate (IMs), iduronosyl anhydro[1- 3 H]mannitol, phenyl iduronide (PhI) and 4-methylumbelliferyl iduronide have been compared as substrates for the diagnostic estimation of α-l-iduronidase activity present in human leucocyte...
Clin Sci (Lond) (1981) 61 (1): 43–46.
Published: 01 July 1981
...M. A. Mansell; A. J. Grimes; N. F. Jones 1. We have measured adenosine 5′-triphosphate (ATP) levels in isolated leucocyte suspensions from patients with renal failure. 2. Leucocyte ATP is reduced in these patients, unlike erythrocyte ATP which is known to be elevated in uraemia. 3. The relevance...
Clin Sci (Lond) (1981) 60 (2): 237–239.
Published: 01 February 1981
...R. B. Jones; P. W. N. Keeling; P. J. Hilton; R. P. H. Thompson 1. A significant correlation between leucocyte and muscle zinc contents was observed in control patients and in patients with generalized diseases. 2. As muscle contains a large proportion of the whole-body zinc, it is suggested...
Clin Sci (Lond) (1980) 59 (s6): 199s–201s.
Published: 01 December 1980
...T. E. Forrester; G. A. O. Alleyne 1. Leucocyte electrolytes were measured in pre-eclampsia and comparison was made with leucocytes from normal primigravidae and from the original pre-eclamptic subjects 6 months after delivery when blood pressure had returned to normal. 2. In pre-eclamptic subjects...
Clin Sci (Lond) (1980) 58 (1): 111–114.
Published: 01 January 1980
...K. Bartlett; T. Horsburgh; D. Gompertz 1. A newly developed biotin assay was used to monitor plasma and urinary biotin concentration after the oral administration of biotin. 2. In two normal subjects, leucocyte propionyl-CoA carboxylase and β-methylcrotonyl-CoA carboxylase were markedly stimulated...
Clin Sci (Lond) (1979) 56 (4): 385–388.
Published: 01 April 1979
...R. B. Jones; Valerie E. Johnson; J. Patrick; P. J. Hilton 1. Leucocytes were isolated from blood of healthy volunteer subjects and incubated in media of which the bicarbonate, P co 2 and pH composition were varied. 2. The intracellular sodium, potassium and water content of leucocytes were...
Clin Sci Mol Med (1978) 55 (4): 355–363.
Published: 01 October 1978
...A. N. Alam; Lucilla Poston; S. P. Wilkinson; C. G. Golindano; R. Williams 1. The mechanism underlying the raised leucocyte sodium content in fulminant hepatic failure was studied by measurement of sodium fluxes, (Na + + K + )-dependent adenosine triphosphatase activity, and leucocyte ATP content. 2...
Clin Sci Mol Med (1978) 54 (5): 585–587.
Published: 01 May 1978
...J. Patrick; J. Michael; M. N. Golden; B. E. Golden; P. J. Hilton 1. In a preparation of human leucocytes maintained in tissue culture fluid, increasing the extracellular zinc concentration leads to a significant increase in both ouabain-sensitive sodium efflux and in sodium influx. 2. Cell water...
Clin Sci Mol Med (1975) 49 (6): 591–596.
Published: 01 December 1975
...A. W. Segal; T. J. Peters 1. A simple quantitative test has been developed to investigate phagocyte function. 2. This test is performed by the addition of Nitroblue Tetrazolium to whole blood, followed by the isolation of leucocytes on a column of nylon wool. Dye reduction by phagocytes is apparent...
Clin Sci Mol Med (1975) 49 (5): 385–390.
Published: 01 November 1975
...P. J. Hilton; R. P. S. Edmondson; R. D. Thomas; J. Patrick 1. Sodium and potassium transport rates in human leucocytes were measured in vitro at different external potassium concentrations. 2. At nominally zero external potassium concentrations, the ouabain-sensitive sodium efflux was reduced...
Clin Sci Mol Med (1975) 49 (3): 213–216.
Published: 01 September 1975
...R. P. S. Edmondson; P. J. Hilton; N. F. Jones; J. Patrick; R. D. Thomas 1. In sixteen patients with severe chronic renal failure the rate constant for total sodium efflux from leucocytes was significantly reduced compared with that in thirty control subjects. This difference lay chiefly...
Clin Sci Mol Med (1975) 48 (s2): 169s–170s.
Published: 01 January 1975
...R. D. Thomas; R. P. S. Edmondson; P. J. Hilton; N. F. Jones 1. In seventeen patients with untreated essential hypertension the sodium and water contents of leucocytes were significantly increased, whereas the rate constant for ouabain-sensitive sodium efflux was significantly reduced. 2...
Clin Sci Mol Med (1974) 46 (5): 583–590.
Published: 01 May 1974
...J. Patrick; N. F. Jones 1. The leucocyte has been used as a model for the study of intracellular sodium, potassium and water in uraemia. The advantages of this cell are described. 2. In undialysed patients with advanced renal failure leucocyte sodium and water contents were significantly greater...
Clin Sci Mol Med (1973) 44 (5): 457–465.
Published: 01 May 1973
...J. Patrick; P. J. Hilton 1. The effect of variations in extracellular osmolality from 249 to 345 mosmol/kg upon the sodium, potassium and water content of human leucocytes has been studied. 2. Similar studies were performed using human erythrocytes. 3. Changes in the leucocyte water content were...
Clin Sci (1972) 43 (5): 669–678.
Published: 01 November 1972
...J. Patrick; N. F. Jones; Berenice Bradford; Judith Gaunt 1. The potassium status of uraemic patients was assessed by measurements of leucocyte potassium, erythrocyte potassium, exchangeable potassium ( 42 K) and total body water ( 3 H). The difficulties involved in assessment of exchangeable...