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Keywords: leukaemia
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Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
...Reinhold Munker; George A. Calin The diagnosis of cancer has undergone major changes in the last 40 years. Once based purely on morphology, diagnosis has come to incorporate immunological, cytogenetic and molecular methods. Many cancers, especially leukaemias, are now defined by molecular markers...
Clin Sci (Lond) (2006) 111 (4): 233–249.
Published: 13 September 2006
..., is of major importance in the development of many haematological malignancies. An understanding of the mechanisms by which BCR - ABL contributes to the pathogenesis of chronic myeloid leukaemia led to the development of imatinib, the first of several tyrosine kinase inhibitors to enter clinical trials...
In Collection
Clin Sci (Lond) (2005) 109 (4): 365–379.
Published: 23 September 2005
... example of the value of this technology for clinical diagnostics. The widespread use of qRT-PCR assays for diagnosis and the detection of disease-specific prognostic markers in leukaemia patients provide further examples of their usefulness. Their value for the detection of disease-associated mRNA...
Clin Sci (Lond) (1986) 71 (1): 81–88.
Published: 01 July 1986
... intracellular ATP concentrations were measured by a bioluminescence ATP assay. 2. There was a clear dose-effect relationship in acute leukaemia and chronic lymphocytic leukaemia cells for drugs used in the treatment of leukaemias. A good correlation was found between the ATP content of leukaemic cells and cell...
Clin Sci (Lond) (1984) 66 (2): 147–154.
Published: 01 February 1984
...Aviva Lapidot; Itzhak Nissim; Matityahu Shaklai; Ruth Samuel; Uri A. Liberman 1. Turnover parameters for plasma glycine were measured by administration of a single dose of [ 15 N]glycine to overnight fasted healthy volunteers, nine patients with chronic leukaemia, one patient with acute monocytic...
Clin Sci (Lond) (1981) 60 (2): 191–198.
Published: 01 February 1981
...A. L. Harris; D. G. Grahame-Smith; C. G. Potter; C. Bunch 1. The conversion of cytosine arabinoside into its active metabolite cytosine arabinoside triphosphate, and catabolism by deamination to uracil arabinoside, was measured in intact marrow myeloblasts from patients with acute myeloid leukaemia...
Clin Sci Mol Med (1975) 48 (5): 441–451.
Published: 01 May 1975
..., kidney or spleen ferritin. Reticulocyte ferritin appears to have similar characteristics to heart ferritin. 2. Serum ferritin from normal subjects and patients with various degrees of iron load, leukaemia or liver disease all have a much lower affinity for the anion-exchange column than any tissue...