... remodeling started, but kidney function is preserved. We examined plasmatic pro-oxidant and antioxidant status showing a significant alteration in oxidative balance in SHR. As index of oxidative damage, we evaluated lipid peroxidation in kidney, liver, and skeletal muscle, detecting a significant rise...

... antioxidant status antioxidant vitamin blood pressure essential hypertension lipid peroxidation oxidative stress An increasing body of evidence suggests that oxidative stress is involved in the pathophysiological mechanism of hypertension [ 1 – 3 ], which is considered to be the most important...

... in adipose tissue, and (iii) hepatic lipid peroxidation and protein oxidation indexes. It is concluded that a marked enhancement in LCPUFA n -6/ n -3 ratio occurs in the liver of NAFLD patients, a condition that may favour lipid synthesis over oxidation and secretion, thereby leading to steatosis. Depletion...

...Annika SMEDMAN; Bengt VESSBY; Samar BASU We have found previously that supplementation with conjugated linoleic acid (CLA) induces lipid peroxidation and inflammation in humans as indicated by an increase of 8-iso-prostaglandin F 2α (PGF 2α ) and 15-keto-dihydro-PGF 2α respectively. The present...

[email protected] ). 4 6 2001 10 7 2001 14 9 2001 The Biochemical Society and the Medical Research Society © 2002 2002 inflammation isoprostanes lipid peroxidation migraine oxidative stress prostaglandins. 39Clinical Science (2002) 102, 39 43 (Printed in Great Britain...

...) there was no competition for uptake between phytanic acid and α-tocopherol, and (d) the incorporation of phytanic acid did not increase the susceptibility of membranes to lipid peroxidation in vitro . These results obtained with cultured retinal cells suggest that the molecular distortion hypothesis, but not the anti...

... was related to enhanced exercise-induced mobilization/oxidation of blood lipids due to a selective increase in o 2max ( P < 0.05 compared with normoxic group). We conclude that lipid peroxidation induced by acute exercise (1) increases during hypoxia; (2) is not regulated exclusively by a mass action...

... 1 month of daily CLA intake (4.2 g/day) as compared with the control group. The lipid peroxidation parameters had returned to their basal levels at 2 weeks after the cessation of CLA intake, and remained at the same levels for a further 2 weeks until the end of the study. CLA had no effect on serum...

... The Biochemical Society and the Medical Research Society © 2000 2000 ascorbic acid CCl4 glutathione lipid peroxidation vitamin C vitamin E 315Clinical Science (2000) 99, 315 320 (Printed in Great Britain) S-Adenosylmethionine prevents hepatic tocopherol depletion in carbon tetrachloride-injured rats...

... of the complications of prematurity. 2. Plasma total antioxidant status and malondialdehyde concentration were measured during the first 11 days of life in 25 infants to determine whether increased lipid peroxidation is associated with low extracellular antioxidant status. In a second group of infants, total...

... bind iron, but the redox activity of this iron has not been fully investigated. 3. The ability of albumin to bind iron and to prevent iron-dependent lipid peroxidation in vitro was investigated using liposomes and a rat brain homogenate system. 4. The iron-binding capacity of albumin was found...

...Anne Barden; Lawrence J. Beilin; Jackie Ritchie; Kevin D. Croft; Barry N. Walters; Constantine A. Michael 1. This study was designed to seek evidence for excessive lipid peroxidation in pre-eclamptic women using 8-iso-prostane as a novel bioactive marker of lipid peroxidation in vivo. Plasma free...

...Rakesh Kakkar; Subrahmanyam V. Mantha; Jawahar Kalra; Kailash Prasad 1. Oxygen free radicals have been suggested to be a contributory factor in complications of diabetes mellitus. In the present study, we investigated the lipid peroxide level [thiobarbituric acid-reactive substances (TBARS...

... antioxidant enzyme activities in smokers compared with non-smokers, erythrocytes from smokers were more susceptible to hydrogen peroxide-induced lipid peroxidation in vitro. 5. Vitamin E supplementation further increased erythrocyte catalase (EC 1.11.1.6) activity in both smokers and non-smokers ( P...

... beneficial aortic prostanoid production, attenuated lipid peroxidation and significantly suppressed atherosclerosis. 3. These results suggest that a high-cholesterol diet induces more atherosclerotic lesions, especially on the ascending aorta, in rabbits. A fish oil supplement favours prostanoid production...

...Jordi Camps; Teresa Bargallo; America Gimenez; Silvia Alie; Joan Caballeria; Albert Pares; Jorge Joven; Lluis Masana; Joan Rodes 1. Lipid peroxidation and hepatic fibrogenesis were investigated in 25 carbon tetrachloride-treated rats and in 25 control animals. Rats were further divided into two...

.... These findings are consistent with the consumption of α-tocopherol within the inflamed joint via its role in terminating the process of lipid peroxidation. 3. Nuclear magnetic resonance spectroscopic analysis of matched inflammatory synovial fluid and serum confirmed lower concentrations of triacylglycerol...

.... 25 3 1991 11 4 1991 © 1991 The Biochemical Society and the Medical Research Society 1991 antioxidant bleomycin caeruloplasmin lipid peroxidation oxygen radicals vitamin C supplementation Clinical Science (1991) 81, 413-417 413 Plasma ascorbate levels and inhibition...

... peroxidation in membranes [8,9]. In contrast, iron bound to transferrin is ineffective in stimulating lipid peroxidation [lo] and is a t best only weakly active in promoting the formation of hydroxyl radicals [8]. Gutteridge et al. [ 11,121 have developed an assay for iron complexes that are capable of taking...

...David Rowley; John M. C. Gutteridge; David Blake; Margaret Farrs; Barry Halliwell 1. Thiobarbituric acid (TBA)-reactive material is present in serum and knee joint synovial fluid from rheumatoid patients, consistent with lipid peroxidation occurring in vivo. 2. The amount of TBA-reactive material...

... lipid peroxidation thalassaemia Clinical Science (1981) 60, 295-301 Lipid peroxidation in iron-overloaded spleens A. D. HEYS AND T. L. DORMANDY Department 01Chemical Pathology, Whittington Hospital, London (Received 24 June 1980; accepted 13 October 1980) 295 Summary 1. Iron-overloaded spleens from...