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Helena L. Fisk, Caroline E. Childs, Elizabeth A. Miles, Robert Ayres, Paul S. Noakes, Carolina Paras-Chavez, Ondrej Kuda, Jan Kopecký, Elie Antoun, Karen A. Lillycrop, Philip C. Calder
Clin Sci (Lond) (2021) 135 (1): 185–200.
Published: 08 January 2021
... and adjusted to mg protein used to give activity in pmol/min/mg. RNA was isolated from scWAT stored in RNAlater using the RNeasy lipid tissue mini kit™ (QIAGEN, Hilden, Germany). The kit protocol was carried out twice to yield RNA from ∼2 × 75 mg of scWAT in total from each participant yielding an average...
Includes: Supplementary data
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
.... , Walter V. , Everett B. , Libby P. , Hensen J. ( 2012 ) Effects of Interleukin-1beta inhibition with canakinumab on hemoglobin a1c, lipids, c-reactive protein, interleukin-6, and fibrinogen: a phase iib randomized placebo controlled trial . Circulation 126 , 2739 – 2748...
Rui Curi, Renata de Siqueira Mendes, Luiz Aurélio de Campos Crispin, Giuseppe Danilo Norata, Sandra Coccuzzo Sampaio, Philip Newsholme
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
...). Glutamine plays an essential role in macrophage metabolism and function, as it is required for energy production but also provides nitrogen for synthesis of purines, pyrimidines and thus RNA. Macrophages also utilize fatty acids for both energy production in the mitochondria and lipid synthesis essential...
Clin Sci (Lond) (2015) 129 (12): 1195–1206.
Published: 11 November 2015
... intervention decreased protein carbonyls (2.5±0.4 compared with 3.95±0.2 nmol/mg; P <0.001) and 8-isoprostane F2α (30.4±4.0 pg/ml compared with 43.5±8.42 pg/ml; P <0.05). HMVEC treatment with LDL-lipids (LDL-L) from hyperlipidaemic, AD and AD-plus subjects impaired endothelial tight junction expression...
Includes: Supplementary data
Marta Toral, Miguel Romero, Rosario Jiménez, Ayman Moawad Mahmoud, Emma Barroso, Manuel Gómez-Guzmán, Manuel Sánchez, Ángel Cogolludo, Ana B. García-Redondo, Ana M. Briones, Manuel Vázquez-Carrera, Francisco Pérez-Vizcaíno, Juan Duarte
Clin Sci (Lond) (2015) 129 (9): 823–837.
Published: 07 August 2015
..., and phosphorylation of eNOS at Thr 495 induced by palmitate in MAECs, which were abolished by etomoxir. In conclusion, PPARβ/δ activation restored the lipid-induced endothelial dysfunction by up-regulation of CPT-1, thus reducing DAG accumulation and the subsequent PKC-mediated ROS production and eNOS inhibition...
Includes: Supplementary data
Clin Sci (Lond) (2004) 106 (5): 547–548.
Published: 01 May 2004
... related to insulin resistance measured in terms Key words: blood flow, glucose, haemodynamics, insulin, lipids. Abbreviations: ATBF, adipose tissue blood flow; NEFA, non-esterified fatty acid. Correspondence: Professor Keith Frayn (e-mail firstname.lastname@example.org). of metabolic events [5,12]. From...
Clin Sci (Lond) (2004) 106 (1): 93–98.
Published: 01 January 2004
...V. TOESCU; S. L. NUTTALL; U. MARTIN; P. NIGHTINGALE; M. J. KENDALL; P. BRYDON; F. DUNNE The purpose of the present study was to determine changes in plasma lipids and markers of oxidative stress longitudinally in pregnancy complicated by diabetes compared with non-diabetic pregnancy...
Clin Sci (Lond) (2003) 105 (6): 715–721.
Published: 01 December 2003
... Society 2003 blood flow glucose haemodynamics insulin lipids Clinical Science (2003) 105, 715 721 (Printed in Great Britain) 715 Central and peripheral haemodynamic effects of hyperglycaemia, hyperinsulinaemia, hyperlipidaemia or a mixed meal Andreas FUGMANN, Jonas MILLGA RD, Mahziar SARABI...
Lars LIND, Andreas FUGMANN, Stefan BRANTH, Bengt VESSBY, Jonas MILLGÅRD, Christian BERNE, Hans LITHELL
Clin Sci (Lond) (2000) 99 (3): 169–174.
Published: 01 August 2000
.... Forearm blood flow was measured by venous occlusion plethysmography. Lipid oxidation was determined by measuring plasma malondialdehyde levels. Infusion of Intralipid ® plus heparin increased the concentration of non-esterified fatty acids to 2.6±1.2 mmol/l and decreased EDV from 27.6±8.7 to 21.0±5.7...
Clin Sci (Lond) (2000) 98 (1): 21–30.
Published: 19 November 1999
...H. MERZOUK; S. MADANI; D. CHABANE SARI; J. PROST; M. BOUCHENAK; J. BELLEVILLE The aim of this investigation was to determine the time course of changes in serum glucose, insulin and lipid levels, as well as lipid and protein content and lipolytic activities in insulin target organs (liver, adipose...
Clin Sci (Lond) (1998) 95 (4): 479–487.
Published: 01 October 1998
...Cliona NÍ MHURCHÚ; Barrie M. MARGETTS; Viv SPELLER 1. Intervention trials in free-living populations have shown relatively small reductions in risk factors for cardiovascular disease, including lipid levels, and have led some to question whether diet is an effective treatment for hyperlipidaemia...
Clin Sci (Lond) (1998) 95 (2): 213–217.
Published: 01 August 1998
...F. DE LORENZO; M. MUKHERJEE; Z. KADZIOLA; R. SHERWOOD; V. V. KAKKAR 1. A prospective study has been carried out, and 68 patients with hypercholesterolaemia have been investigated to study the effects of central cooling on serum lipid levels. 2. Central cooling was obtained by the exposure...
Iftikhar Ul Haq, Lawrence E. Ramsay, David M. Pickin, Wilfred W. Yeo, Peter R. Jackson, John N. Payne
Clin Sci (Lond) (1996) 91 (4): 399–413.
Published: 01 October 1996
...Iftikhar Ul Haq; Lawrence E. Ramsay; David M. Pickin; Wilfred W. Yeo; Peter R. Jackson; John N. Payne 1. Recent outcome trials suggest that lipid-lowering with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors is justifiable on risk-benefit grounds in subjects with serum cholesterol...
Clin Sci (Lond) (1993) 84 (6): 593–597.
Published: 01 June 1993
... Research Society 1993 aortic compliance aortic distensibility insulin-like growth factor-I lipids low-density lipoprotein-cholesterol Clinical Science (1993) 84, 593-597 (Printed in Great Britain) Biochemical correlates of aortic distensibility in vivo in normal subjects K. D. HOPKINSI, E. D...
Simon W. Dubrey, David A. Reaveley, David G. Leslie, Martina O'Donnell, Bernadette M. O'Connor, Mary Seed
Clin Sci (Lond) (1993) 84 (5): 537–542.
Published: 01 May 1993
...Simon W. Dubrey; David A. Reaveley; David G. Leslie; Martina O'Donnell; Bernadette M. O'Connor; Mary Seed 1. Forty-five identical twin pairs, discordant for insulin-dependent diabetes mellitus, were studied with respect to their serum lipid (high-density lipoprotein, low-density lipoprotein, total...
Clin Sci (Lond) (1991) 81 (6): 793–798.
Published: 01 December 1991
... dolorosa, calorimetry, fat-cell size, fatty acid composition, heat production, lipids, lipoprotein lipase, obesity, pain. Correspondence: Dr Birger Fagher, Department of Internal Medicine, University Hospital of Lund, S-221 85 Lund, Sweden. 1991; accepted 16 July 1991) Abbreviations: BMI, body mass index...
Clin Sci (Lond) (1987) 73 (5): 497–500.
Published: 01 November 1987
... were significantly reduced (pre-feeding median 7.20%/min, range 4.72–12.12%/min, post-feeding median 4.44%/min, range 2.17–6.83%/min, P < 0.05). 17 3 1987 11 5 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 body weight colonic neoplasms lipids...
Clin Sci (Lond) (1986) 70 (1): 23–29.
Published: 01 January 1986
... peritoneal dialysis, glucose, glycerol, lipids, osmotic pressure, peritoneal dialysis. Abbreviations: CAPD, continuous ambulatory peritoneal dialysis; HDL, high density lipoprotein; LDH, lactic dehydrogenase; LDL, low density lipoprotein; SGOT, serum glutamic-oxaloacetic transaminase; VLDL, very low density...
Barrie M. Margetts, Lawrence J. Beilin, Bruce K. Armstrong, Ian L. Rouse, Robert Vandongen, Kevin D. Croft, Edward J. Mcmurchie
Clin Sci (Lond) (1985) 69 (2): 165–175.
Published: 01 August 1985
... pressures. Adjustment of blood pressure changes for changes in electrolytes, other dietary components, plasma lipids, weight and other lifestyle variables did not alter this result. 5. It was concluded that the blood pressure lowering effect of a vegetarian diet reported previously was unlikely to have been...
Clin Sci (Lond) (1979) 57 (s5): 405s–407s.
Published: 01 December 1979
...A. Lehtonen; J. Viikari 1. We studied the effect on plasma lipids of sotalol given orally over a 12 month period to patients with essential hypertension. 2. Plasma free fatty acid concentration was lower than initially at 1, 3, 6 and 12 months. The difference was significant ( P < 0·01) at 1...
Clin Sci Mol Med (1978) 55 (s4): 325s–328s.
Published: 01 December 1978
...Z. Glück; G. Baumgartner; P. Weidmann; E. Peheim; C. Bachmann; R. Mordasini; J. Flammer; G. Keusch 1. The effect of diuretic therapy on serum lipids and lipoprotein fractions was evaluated in 16 normal or labile hypertensive subjects who received in cross-over fashion chlorthalidone, frusemide...
Clin Sci Mol Med (1977) 53 (3): 205–214.
Published: 01 September 1977
... Society and the Medical Research Society 1977 alcohol ethanol glycogen lipids muscle oleic acid Clinical Science and Molecular Medicine (1977) 53, 205-214. Influence of ethanol on non-esterified fatty acid and carbohydrate metabolism during exercise in man A. JUHLIN-DANNFELT, L. JORFELDT, L...