...Kenneth Verboven; Rudi Stinkens; Dominique Hansen; Inez Wens; Ines Frederix; Bert O. Eijnde; Johan W.E. Jocken; Gijs H. Goossens; Ellen E. Blaak Obesity-related adipose tissue (AT) dysfunction, in particular subcutaneous AT (SCAT) lipolysis, is characterized by catecholamine resistance and impaired...

...Kenneth Verboven; Dominique Hansen; Cedric Moro; Bert O. Eijnde; Nicole Hoebers; Joep Knol; Wim Bouckaert; Anne Dams; Ellen E. Blaak; Johan W.E. Jocken Catecholamines and atrial natriuretic peptide (ANP) are major regulators of adipocyte lipolysis. Although obesity is characterized by catecholamine...

...Ee L. Lim; Kieren G. Hollingsworth; Fiona E. Smith; Peter E. Thelwall; Roy Taylor Suppression of lipolysis by acipimox is known to improve insulin-stimulated glucose disposal, and this is an important phenomenon. The mechanism has been assumed to be an enhancement of glucose storage as glycogen...

..., but the sensitivity of lipolysis was impaired in patients with sepsis. In conclusion, sepsis impaired to a varying extent the action of insulin on endogenous glucose production, glucose utilization, lipolysis and ketogenesis. Whole-body glucose uptake was the most affected, with a total lack of response...

... by fasting. 26 1 1994 11 7 1994 22 8 1994 © 1994 The Biochemical Society and the Medical Research Society 1994 euglycaemic clamp fasting glucose-induced thermogenesis lipolysis [I- 13 C]palmitate stable isotope Clinical Science (1994) 87, 697-706 (Printed in Great Britain...

... for this observation is that GR 79236 stimulated gastric emptying leading to enhanced absorption of stomach contents when compared with untreated animals. adenosine receptor agonist diabetic ketoacidosis lipolysis 8 11 1993 19 11 1993 © 1994 The Biochemical Society and the Medical Research...

... of a ‘hormone’ stimulating lipolysis in human adipose tissue in viva The effect of noradrenaline in significantly increasing the ratio of non-esterified fatty acid to glycerol release by adipose tissue may be partly explained by accumulation in adipose tissue of diacylglycerol, which is associated with release...

... orally. Lipolytic activity after stimulation with various adrenergic agents was measured, using glycerol release as an index of lipolysis. The number of β 1 - and β 2 -adrenoceptor binding sites was determined in radioligand binding experiments and β 1 - and β2-adrenoceptor mRNA levels were measured...

... administered by infusion, but not by injection, decreased the plasma non-esterified fatty acid concentration. The plasma glycerol concentration also decreased after infusion of platelet-activating factor, suggesting decreased lipolysis in adipose tissue. 5. Changes in plasma insulin concentration or white...

... The Biochemical Society and the Medical Research Society 1992 adrenaline α-adrenoceptors lipolysis phentolamine platelet aggregability Clinical Science (1992) 82, 369-376 (Printed in Great Britain) a-Adrenoceptor blockade by phentolamine inhibits adrenaline-induced platelet activation in vivo without...

... of adipose tissue lipolysis. There were parallel increases in the plasma level of triacylglycerols. Neither cytokine had significant effects on blood or liver total ketone body (acetoacetate plus 3-hydroxybutyrate) concentrations. 2. In starved rats, the higher plasma non-esterified fatty acid concentration...

... immunodeficiency syndrome fasting glucose lipolysis non-esterified fatty acids triacylglycerols tumour necrosis factor 29 10 1990 21 11 1990 © 1991 The Biochemical Society and the Medical Research Society 1991 Clinical Science (1991) 80,359-365 359 Basal fuel homoeostasis...

... and circulating free fatty acid and glycerol levels at an infusion rate of 10 μg min −1 kg −1 , presumably due to stimulation of lipolysis. 23 3 1990 27 6 1990 5 7 1990 © 1990 The Biochemical Society and the Medical Research Society 1990 catecholamines dopamine infusion glucose...

... of tissue ( P <0.01). Acipimox at 10 −4 -10 −2 mmol/l had no consistent effect on cholesterol synthesis. 4. Acipimox appears to exert its main hypolipidaemic effect by reducing lipolysis and free fatty acid flux to the liver, thereby reducing the precursor pool size of very low density lipoprotein (VLDL...

... fatty acids and ketone bodies were lowered, particularly with hypertonic dialysis fluid. 5. The long-term effects of sustained hyper-insulinaemia, including suppression of lipolysis and ketogenesis, require further investigation. 26 1 1983 29 4 1983 © 1983 The Biochemical Society...

... Society and the Medical Research Society 1983 acylglycerol adipose tissue lipogenesis lipolysis nicotinic acid Clinical Science (1983) 64,235-237 SHOR T COMMUNICA TION 235 Effect of nicotinic acid on acylglycerol metabolism in human adipose tissue PETER ARNER A N D JAN OSTMAN Department...

...P. Arner; J. Östman 1. The activation of lipolysis on incubation of human subcutaneous adipose tissue was examined in terms of the relationship between the release of glycerol and the concentration of tissue cyclic AMP. 2. A strong positive correlation was obtained between the maximum concentration...

... Research Society 1980 cyclic AMP diabetes mellitus insulin resistance lipolysis Clinical Science (1980) 58.59-63 Peripheral resistance to the cellular action of insulin in obese diabetic subjects in vivo J . P . D . R E C K L E S S * AND D . J . G A L T O N Diabetes and Lipid Research...

... no differences in this aspect are seen between the leg metabolism of diabetic and normal subjects. diabetes exercise muscle metabolism insulin lipolysis © 1978 The Biochemical Society and the Medical Research Society 1978 9 8 1977 9 2 1978 Clinical Science and Molecular Medicine (1...

... tension and heart rate, followed shortly thereafter by marked deterioration in mechanical performance to levels below those observed in the control state. These latter responses occurred simultaneously with stimulation of endogenous myocardial lipolysis. The rate of release of non-esterified fatty acids...

... was unchanged by CPIB. 5. These findings indicate that the lowering effect of CPIB on non-esterified fatty acid concentrations derives principally from decreased mobilization rather than from increased tissue uptake of the fatty acids, and that this reflects both inhibited lipolysis and enhanced re...