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Keywords: lipotoxicity
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Articles
Clin Sci (Lond) (2021) 135 (19): 2265–2283.
Published: 13 October 2021
... accumulation and subsequent lipotoxicity. Correspondence: J. Leggat ( jl687@medschl.cam.ac.uk ) 17 05 2021 28 09 2021 29 09 2021 © 2021 The Author(s). 2021 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed...
Articles
Clin Sci (Lond) (2016) 130 (3): 193–203.
Published: 17 December 2015
... lipotoxicity induced by palmitate. IL-22 prevented lipotoxicity through PI3K (phosphoinositide 3-kinase)-mediated inhibition of JNK, but did not play a protective role in the presence of IL-17, which up-regulated the PI3K/Akt inhibitor PTEN (phosphatase and tensin homologue deleted on chromosome 10...
Articles
Clin Sci (Lond) (2011) 120 (5): 179–181.
Published: 19 November 2010
.... Correspondence: Dr Henrik Ortsäter (email henrik.ortsater@sodersjukhuset.se ). 25 10 2010 2 11 2010 2 11 2010 2 11 2010 © The Authors Journal compilation © 2011 Biochemical Society 2011 arachidonic acid lipotoxicity palmitic acid pancreatic β-cell reactive oxygen species...
Articles
Clin Sci (Lond) (2011) 120 (5): 195–206.
Published: 19 November 2010
... and protective β-cell action, which may be beneficial to function and survival in the ‘lipotoxic’ environment commonly associated with Type 2 diabetes mellitus. 1 These authors contributed equally to this work. Correspondence: Professor Philip Newsholme (email philip.newsholme@ucd.ie ). 1 6...
Articles
Clin Sci (Lond) (2010) 119 (3): 123–129.
Published: 28 April 2010
... in the lower-body compartment and obese women in central compartments. In the non-pregnant, central storage of fat is associated with adipocyte hypertrophy and represents a failure to adequately store excess fatty acids, resulting in metabolic dysregulation and ectopic fat accumulation (lipotoxicity). Obese...