...Alison F. C. LEE; John B. C. DICK; Clare E. BONNAR; Allan D. STRUTHERS Endothelial function is defective in hypercholesterolaemia, and animal models have suggested that angiotensin-converting enzyme inhibitors may prevent arterial damage. We studied the effect of 6 months treatment with lisinopril...

... renal tubular protein catabolism or markers of tubular injury before and after lisinopril. We developed a method to allow such studies, and found increased tubular catabolism of 99m Tc-labelled aprotinin (Trasylol) in patients with nephrotic range proteinuria which was associated with increased ammonia...

... in 96 male Wistar rats with established adriamycin nephrosis. Reduction of proteinuria was achieved by lisinopril (0, 2, 5 and 10 mg day −1 kg −1 ) on two different sodium diets (03% and 0.05% NaCl). Therapy started 6 weeks after adriamycin (at stable proteinuria) and was continued for 6 weeks. 3...

...Jan E. Heeg; Paul E. de Jong; Dick de Zeeuw 1. Both the angiotensin-converting enzyme inhibitor, lisinopril, and the non-steroidal anti-inflammatory drug, indomethacin, lower urinary protein excretion in renal disease and improve the selectivity of the residual proteinuria. Despite the clearly...