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Keywords: liver
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Articles
Metformin alleviates HFD-induced oxidative stress in hepatocyte via activating SIRT6/PGC-1α/ENDOG signaling
Available to PurchaseShuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (22): 1711–1730.
Published: 30 November 2022
... evidenced that during HFD-induced obesity, there was elevation of nucleus protein acetylation. Analysis of liver tissue showed that among all SIRT members, SIRT6 expression was significantly down-regulated during HFD feeding, which was sustained to regular level with metformin administration. Our result...
Includes: Supplementary data
Articles
Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1111–1115.
Published: 01 August 2022
...Federico F. De Ponti; Charlotte L. Scott Non-alcoholic steatohepatitis (NASH) and associated end-stage liver disease is a growing cause of concern throughout the Western world. It constitutes a significant clinical burden for which therapeutic approaches are very limited. Over the last years...
Articles
DUSP12 protects against hepatic ischemia–reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (17): 2279–2294.
Published: 03 September 2020
...Tao Qiu; Tianyu Wang; Jiangqiao Zhou; Zhongbao Chen; Jilin Zou; Long Zhang; Xiaoxiong Ma Hepatic ischemia–reperfusion (I/R) injury is an important risk factor resulting in liver failure during liver surgery. However, there is still lack of effective therapeutic methods to treat hepatic I/R injury...
Includes: Supplementary data
Articles
GDF11 impairs liver regeneration in mice after partial hepatectomy
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Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (20): 2069–2084.
Published: 22 October 2019
... in liver regeneration is unclear. Here, we investigated the pathophysiologic role of GDF11, as well as its plausible signaling mechanisms in a mouse model of partial hepatectomy (PH). We demonstrated that both serum and hepatic GDF11 protein expression increased following PH. Treatment with adeno...
Includes: Supplementary data
Articles
USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling
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Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 335–349.
Published: 30 January 2019
... results indicated that USP4 was significantly up-regulated in liver of mice subjected to hepatic I/R injury. USP4 knockout mice exhibited exacerbated hepatic I/R injury, as evidenced by enhanced liver inflammation via the nuclear factor κB (NF-κB) signalling pathway and increased hepatocyte apoptosis...
Articles
Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes
Available to PurchaseTong-Yan Liu, Chang-Xiang Shi, Run Gao, Hai-Jian Sun, Xiao-Qing Xiong, Lei Ding, Qi Chen, Yue-Hua Li, Jue-Jin Wang, Yu-Ming Kang, Guo-Qing Zhu
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (10): 839–850.
Published: 19 August 2015
... and G6Pase expression in the liver. Irisin improves glucose homoeostasis by reducing gluconeogenesis via PI3K/Akt/FOXO1-mediated PEPCK and G6Pase down-regulation and increasing glycogenesis via PI3K/Akt/GSK3-mediated GS activation. Irisin may be regarded as a novel therapeutic strategy for insulin resistance...
Includes: Supplementary data
Articles
Feasibility of global miRNA analysis from fine-needle biopsy FFPE material in patients with hepatocellular carcinoma treated with sorafenib
Available to PurchaseJan Peveling-Oberhag, Claudia Döring, Sylvia Hartmann, Natalie Filmann, Angelika Mertens, Albrecht Piiper, Eva Herrmann, Martin-Leo Hansmann, Stefan Zeuzem, Jörg Trojan, Martin-Walter Welker
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (1): 29–37.
Published: 27 August 2014
... patients with advanced HCC treated with sorafenib were included. RNA was extracted from formalin-fixed paraffin-embedded (FFPE) liver biopsies. miRNA expression profiling of 818 mature miRNAs was performed using GeneChip® miRNA Array 2.0 (Affymetrix). Global miRNA patterns were assessed using unsupervised...
Includes: Supplementary data
Articles
Differential bradykinin B 1 and B 2 receptor regulation in cell death induced by hepatic ischaemia/reperfusion injury
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (6): 405–413.
Published: 29 May 2014
.... The aim of the present study was to analyse the role of B 1 R and B 2 R in liver cell death induced by IRI. Livers from Wistar rats were submitted to ischaemia (4°C) for 4 or 24 h. After this period, livers were reperfused ex vivo with Krebs–Henseleit solution (37°C). BK or DABK was then injected...
Articles
Radiofrequency ablation suppresses distant tumour growth in a novel rat model of multifocal hepatocellular carcinoma
Available to PurchaseCaroline Erös de Bethlenfalva-Hora, Joachim C. Mertens, Anne-Christine Piguet, Joachim Kettenbach, Johannes Schmitt, Luigi Terracciano, Rosemarie Weimann, Jean-François Dufour, Andreas Geier
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (3): 243–252.
Published: 09 October 2013
... inhibitor sorafenib prolongs survival in advanced HCC. We examined the effects of RFA alone and in combination with sorafenib on a bystanding tumour in a two-tumour rat model of HCC. A total of 80 rats were implanted with two liver tumours and randomized to four treatment groups: vehicle and sham operation...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (2): 93–98.
Published: 23 March 2012
... (ischaemia/reperfusion) injury in the liver. I/R is the main cause of primary liver failure and, consequently, minimizing the detrimental effects of this process could increase the number of suitable transplantation grafts and also enhance the survival rate of patients after liver transplantation...
Articles
Lipoprotein distribution and serum concentrations of 7α-hydroxy-4-cholesten-3-one and bile acids: effects of monogenic disturbances in high-density lipoprotein metabolism
Available to PurchaseCarine Steiner, Adriaan G. Holleboom, Ratna Karuna, Mohammad M. Motazacker, Jan Albert Kuivenhoven, Ruth Frikke-Schmidt, Anne Tybjaerg-Hansen, Lucia Rohrer, Katharina M. Rentsch, Arnold von Eckardstein
Journal:
Clinical Science
Clin Sci (Lond) (2012) 122 (8): 385–400.
Published: 14 December 2011
..., despite significant recoveries of BAs and C4 in HDL and despite the metabolic relationships between RCT and BA formation, monogenic disorders of HDL metabolism do not lead to altered serum concentrations of BAs and C4. Cholesteryl esters are removed from mature HDL particles mostly by the liver...
Includes: Supplementary data
Articles
Role of Toll-like receptors in liver health and disease
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Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (10): 415–426.
Published: 25 July 2011
... between innate and adaptive immunity. In the liver, TLRs play an important role in the wound healing and regeneration processes, but they are also involved in the pathogenesis and progression of various inflammatory liver diseases, including autoimmune liver disease, alcoholic liver disease, non-alcoholic...
Articles
Remote hindlimb preconditioning and hepatoprotection: NO-table strides against liver ischaemia/reperfusion injury
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (6): 253–255.
Published: 27 May 2011
...Narci C. Teoh Hepatic IR (ischaemia/reperfusion) injury is an important clinical problem complicating liver surgery and transplantation. IPC (ischaemic preconditioning) is a strategy whereby brief episodes of IR in an organ can induce an adaptive response to protect against subsequent prolonged IR...
Articles
Nitric oxide is an essential mediator of the protective effects of remote ischaemic preconditioning in a mouse model of liver ischaemia/reperfusion injury
Available to PurchaseMahmoud Abu-Amara, Shi Yu Yang, Alberto Quaglia, Peter Rowley, Achala De Mel, Niteen Tapuria, Alexander Seifalian, Brian Davidson, Barry Fuller
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (6): 257–266.
Published: 27 May 2011
...Mahmoud Abu-Amara; Shi Yu Yang; Alberto Quaglia; Peter Rowley; Achala De Mel; Niteen Tapuria; Alexander Seifalian; Brian Davidson; Barry Fuller NO (nitric oxide) may protect the liver from IR (ischaemia/reperfusion) injury. RIPC (remote ischaemic preconditioning) also protects against liver IR...
Articles
Delivery by Caesarean section, rather than vaginal delivery, promotes hepatic steatosis in piglets
Available to PurchaseMatthew J. Hyde, Julian L. Griffin, Emilio Herrera, Christopher D. Byrne, Lynne Clarke, Paul R. Kemp
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (1): 47–59.
Published: 02 October 2009
... with metabolomic and genomic approaches. Hepatic lipid in the CS piglets at 7 days post-partum was in excess of 5 mg/g of liver consistent with hepatic steatosis, whereas in the VD piglets the amount of lipid was markedly lower (3 mg/g of liver) and below the threshold for a diagnosis of steatosis. Metabolomic...
Includes: Supplementary data
Articles
Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations
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Journal:
Clinical Science
Clin Sci (Lond) (2008) 115 (5): 141–150.
Published: 01 August 2008
...David Preiss; Naveed Sattar The global increase in the prevalence of obesity has heralded a rise in associated liver injury namely NAFLD (non-alcoholic fatty liver disease). It is estimated that 20–30% of adult populations in developed countries have NAFLD and, although high quality data...
Articles
Decreased hepatosplanchnic antioxidant uptake during hepatic ischaemia/reperfusion in patients undergoing liver resection
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Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (8): 553–560.
Published: 13 March 2008
... preconditioning. The extent and source of oxidative stress and its effect on antioxidant status in the human liver during intermittent ischaemia and reperfusion remains ill-defined. Therefore the aim of the present study was to investigate the occurrence of oxidative stress in humans undergoing liver resection...
Articles
Targeting vessels to treat hepatocellular carcinoma
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (7): 467–477.
Published: 29 February 2008
... importance of inhibitors of angiogenesis in HCC therapy. HCC is the fifth most common cancer in the world and the third most common cause of cancer-related death, with more than 500000 new cases a year [ 21 ]. HCC accounts for more than 80% of primary liver cancers. A total of 80% of HCC cases occur...
Articles
Inhibition of the Ras oncoprotein reduces proliferation of hepatocytes in vitro and in vivo in rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (1): 73–83.
Published: 30 November 2007
... was washed with water, and the organic phase was separated and dried on magnesium sulfate and evaporated. FTS was purified on silica gel with mixtures of chloroform and ethyl acetate. FTS was dissolved in DMSO (20 mg of FTS/500 μl of DMSO) for injection. Livers were homogenized and cells were lysed...
Articles
Familial combined hyperlipidaemia: how can genetic disorders be common, complex and comprehensible?
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (9): 365–367.
Published: 01 October 2007
... to the central role of the liver in defining the FCHL phenotypes and demonstrates how they vary over time in relation to energy excess. On the basis of their work and that of others, we propose that FCHL is a multiple gene/multiple pathway/multiple phenotype disease. The key feature of this model of common...
Articles
Five-year follow-up of waist circumference, insulin and ALT levels in familial combined hyperlipidaemia
Available to PurchaseMartijn C. G. J. Brouwers, Marleen M. J. van Greevenbroek, Vicky M. M.-J. Vermeulen, Josephine M. J. P. van Lin, Carla J. H. van der Kallen, Tjerk W. A. de Bruin
Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (9): 375–381.
Published: 01 October 2007
.... Additionally, the association of ALT with the switch in triacylglycerol phenotype suggests a central role of the liver in the pathogenesis of FCHL. The hypertriglyceridaemic phenotype in FCHL is the consequence of both an excessive production of VLDL (very-low-density lipoprotein) particles and an impaired...
Articles
Liver fibrosis: a balance of ACEs?
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Journal:
Clinical Science
Clin Sci (Lond) (2007) 113 (3): 109–118.
Published: 02 July 2007
...Fiona J. Warner; John S. Lubel; Geoffrey W. McCaughan; Peter W. Angus There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS...
Articles
Liver fibrosis: cellular mechanisms of progression and resolution
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Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (5): 265–280.
Published: 01 February 2007
...Neil C. Henderson; John P. Iredale Liver fibrosis represents a major worldwide health care burden. The last 15 years have seen a rapid growth in our understanding of the pathogenesis of this clinically relevant model of inflammation and repair. This work is likely to inform the design of effective...
Articles
Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis
Available to PurchaseMaria J. Monte, Maria Fernandez-Tagarro, Rocio I. R. Macias, Felipe Jimenez, Francisco Gonzalez-San Martin, Jose J. G. Marin
Journal:
Clinical Science
Clin Sci (Lond) (2005) 109 (2): 199–207.
Published: 25 July 2005
...Maria J. Monte; Maria Fernandez-Tagarro; Rocio I. R. Macias; Felipe Jimenez; Francisco Gonzalez-San Martin; Jose J. G. Marin The relationship between BA (bile acid) secretion (measured by GC–MS) and the expression of genes (measured by reverse transcription real-time PCR) involved in liver BA...
Articles
Therapeutic potential of transdifferentiated cells
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Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (4): 309–321.
Published: 22 March 2005
[email protected] ). 24 11 2004 21 1 2005 The Biochemical Society 2005 liver metaplasia neoplasia pancreas regeneration transdifferentiation Adequate replacement of tissues and organs following injury or disease still remains a major challenge in medicine. Since the first cornea...
Articles
Effect of ischaemic preconditioning on hepatic oxygenation, microcirculation and function in a rat model of moderate hepatic steatosis
Available to PurchaseRahul S. KOTI, Wenxuan YANG, Georgios GLANTZOUNIS, Alberto QUAGLIA, Brian R. DAVIDSON, Alexander M. SEIFALIAN
Journal:
Clinical Science
Clin Sci (Lond) (2005) 108 (1): 55–63.
Published: 15 December 2004
...Rahul S. KOTI; Wenxuan YANG; Georgios GLANTZOUNIS; Alberto QUAGLIA; Brian R. DAVIDSON; Alexander M. SEIFALIAN IPC (ischaemic preconditioning) may protect the steatotic liver, which is particularly susceptible to I/R (ischaemia/reperfusion) injury. Hepatic steatosis was induced in Sprague–Dawley...
Articles
Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone
Available to PurchaseMichael J. O'LEARY, Michael KOLL, Colin N. FERGUSON, John H. COAKLEY, Charles J. HINDS, Victor R. PREEDY, Peter J. GARLICK
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (6): 691–698.
Published: 01 December 2003
...Michael J. O'LEARY; Michael KOLL; Colin N. FERGUSON; John H. COAKLEY; Charles J. HINDS; Victor R. PREEDY; Peter J. GARLICK The effect of sepsis on liver synthesis of albumin remains controversial, with studies in man suggesting that synthesis increases, whereas in animals increased, decreased...
Articles
Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring
Available to PurchaseMaria J. MONTE, Gloria R. VILLANUEVA, Rocio I. R. MACIAS, David J. VAZQUEZ, Marta TOLEDO, Mercedes DOMINGUEZ, Jose J. G. MARIN
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (3): 347–353.
Published: 01 September 2003
... liver microtubule transcytosis tubulin Clinical Science (2003) 105, 347 353 (Printed in Great Britain) 347 Effect of maternal obstructive cholestasis during pregnancy on the biliary transport of horseradish peroxidase in the rat offspring Maria J. MONTE , Gloria R. VILLANUEVA , Rocio I. R. MACIAS...
Articles
Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis
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Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (2): 127–141.
Published: 10 January 2003
...-constant infusions of p -aminohippurate and 3 H-labelled isotopes were used to measure glucose, amino acid and protein metabolism across the portal-drained viscera, liver and hindquarters (to represent muscle) at 0 and 24h of endotoxaemia. Whole-body protein and glucose flux were increased during...
Articles
Pathobiology and experimental therapeutics in hepatocellular cholestasis: lessons from the hepatocyte couplet model
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Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (6): 603–614.
Published: 30 April 2002
...Piotr MILKIEWICZ; Marcelo G. ROMA; Elwyn ELIAS; Roger COLEMAN Preparations of isolated liver cells, either freshly prepared or in culture, have been available for many years; however, because they lack the polarization of the cell in the tissue, their application to the study of processes involved...
Articles
Liver electrolysis: pH can reliably monitor the extent of hepatic ablation in pigs
Available to PurchaseJ. Guy FINCH, Beverley FOSH, Adrian ANTHONY, Eric SLIMANI, Michael TEXLER, David P. BERRY, Ashley R. DENNISON, Guy J. MADDERN
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (4): 389–395.
Published: 04 March 2002
... and humans have shown that it is a safe, predictable and effective process for destroying normal and tumour-bearing liver in a linear, dose-dependent manner. Presently, the amount of current that is applied (in coulombs) has to be calculated using historical data, with inherent inaccuracy. The present study...
Articles
Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (3): 337–344.
Published: 15 February 2002
... liver oxygen consumption. 337Clinical Science (2002) 102, 337 344 (Printed in Great Britain) Hepatocyte mitochondrial metabolism is inhibited in neonatal rat endotoxaemia: effects of glutamine Michele A. MARKLEY, Agostino PIERRO and Simon EATON Department of Paediatric Surgery, Institute of Child...
Articles
The response of liver albumin synthesis to infection in rats varies with the phase of the inflammatory process
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2002) 102 (1): 107–114.
Published: 10 December 2001
...Benoît RUOT; Fabienne BÉCHEREAU; Gérard BAYLE; Denis BREUILLÉ; Christiane OBLED To discriminate between the effects of infection and of anorexia associated with infection, liver albumin synthesis was measured in well-fed rats, in rats injected with live Escherichia coli and in pair-fed rats...
Articles
Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat
Available to PurchaseMichael J. O'LEARY, Colin N. FERGUSON, Michael J. RENNIE, Charles J. HINDS, John H. COAKLEY, Victor R. PREEDY
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (3): 295–304.
Published: 15 August 2001
... was lower at 72 and 96 h, than in sham-operated animals. CLP was associated with increased liver protein synthesis at all time points, whereas there was no change after sham operation. Liver protein content did not change after CLP, but was lower at 72 and 96 h after sham operation than in non-operated...
Articles
Hepatic sugar phosphate levels reflect gluconeogenesis in lung cancer: simultaneous turnover measurements and 31P magnetic resonance spectroscopy in vivo
Available to PurchaseSusanne LEIJ-HALFWERK, Pieter C. DAGNELIE, J. Willem O. VAN DEN BERG, J. H. Paul WILSON, Paul E. SIJENS
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (2): 167–174.
Published: 19 January 2000
...Susanne LEIJ-HALFWERK; Pieter C. DAGNELIE; J. Willem O. VAN DEN BERG; J. H. Paul WILSON; Paul E. SIJENS Stable-isotope tracers were used to assess whether levels of phosphomonoesters (PME) and phosphodiesters (PDE) in the livers of lung cancer patients, as observed by 31 P magnetic resonance (MR...
Articles
Time-Course of Iron Overload and Biochemical, Histopathological and Ultrastructural Evidence of Pancreatic Damage in Hypotransferrinaemic Mice
Available to PurchaseRobert J. Simpson, Jean Deenmamode, Andrew T. McKie, Kishor B. Raja, Jonathan R. Salisbury, Theodore C. Iancu, Timothy J. Peters
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (5): 453–462.
Published: 01 November 1997
... distribution of newly absorbed radioiron suggested that significant redistribution of iron from liver to pancreas (rather than direct dietary iron sources) must be invoked to explain the rate of pancreatic iron loading in hypotransferrinaemic mice. 4. Pancreatic epithelial cells first showed altered morphology...
Articles
Hepatic Preservation with Histidine—Tryptophan—Ketoglutarate Solution in Living-Related and Cadaveric Liver Transplantation
Available to PurchaseEtsuro Hatano, Tetsuya Kiuchi, Akira Tanaka, Hisashi Shinohara, Toshiyuki Kitai, Seiji Satoh, Takuya Inomoto, Hiroto Egawa, Shinji Uemoto, Yukihiro Inomata, Hauke Lang, Karl J Oldhafer, Bruckhardt Ringe, Rudolf Pichlmayr, Koichi Tanaka, Yoshio Yamaoka
Journal:
Clinical Science
Clin Sci (Lond) (1997) 93 (1): 81–88.
Published: 01 July 1997
...Etsuro Hatano; Tetsuya Kiuchi; Akira Tanaka; Hisashi Shinohara; Toshiyuki Kitai; Seiji Satoh; Takuya Inomoto; Hiroto Egawa; Shinji Uemoto; Yukihiro Inomata; Hauke Lang; Karl J Oldhafer; Bruckhardt Ringe; Rudolf Pichlmayr; Koichi Tanaka; Yoshio Yamaoka 1. Living-related liver transplantation has...
Articles
T-Cell Autoimmunity in Primary Biliary Cirrhosis
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Journal:
Clinical Science
Clin Sci (Lond) (1996) 91 (5): 551–558.
Published: 01 November 1996
...David E. J. Jones 1. Primary biliary cirrhosis is a chronic cholestatic liver disease with an autoimmune aetiology. The classical histopathological lesion, of portal tract biliary epithelial cell damage, is accompanied by a T-cell-rich mononuclear cell infiltrate and upregulation of cell surface...
Articles
Differential Effects of a Novel Non-Peptide Endothelin Receptor Antagonist (Bosentan) in Rat Liver and Vasculature
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Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (6): 575–579.
Published: 01 December 1995
... and hepatic membranes by bosentan in vitro was similar. 5. Since bosentan is significantly excreted by the liver, the prolonged hepatic 125 I-ET-1 binding by bosentan presumably represents hepatic accumulation of bosentan, which may have implications for bosentan antagonizing the actions of ET in the liver...
Articles
Regional Sympathetic Nervous Activation after a Large Meal in Humans
Available to PurchaseHelen S. Cox, David M. Kaye, Jane M. Thompson, Andrea G. Turner, Garry L. Jennings, Catherine Itsiopoulos, Murray D. Esler
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (2): 145–154.
Published: 01 August 1995
... nervous activity in healthy, lean subjects. 2. In nine male subjects, noradrenaline spillover was measured from the heart, kidney and liver using isotope dilution, both while fasting and after consumption of a high-energy liquid meal of composition 53% carbohydrate, 32% fat and 15% protein (energy value...
Articles
Cellular Localization of Inducible Nitric Oxide Synthase in Experimental Endotoxic Shock in the Rat
Available to PurchaseH. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... induction was monocytes and macrophages in multiple organs, principally liver and spleen. Bronchial, bile duct, intestinal and bladder epithelium and some hepatocytes also expressed inducible NO synthase. Expression peaked at 5 h and had returned to normal by 12 h except in spleen. 3. After priming with C...
Articles
Loop—Sheet Polymerization: The Structural Basis of Z α 1 -Anti Trypsin Accumulation in the Liver
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (5): 489–495.
Published: 01 May 1994
... the liver of a Z homozygote. 2. That loop—sheet polymerization is a more general phenomenon was shown by the examination of a second deficiency variant, antitrypsin S iiyama (Ser-53→Phe), which is also associated with liver inclusions. Electron microscopy confirmed that isolated antitrypsin S iiyama from...
Articles
Effects of Decreased Glutamine Supply on Gut and Liver Metabolism in vivo in Rats
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (4): 437–444.
Published: 01 October 1993
... for 4 days. Glutamine consumption in portal-drained viscera and liver was measured after an overnight fast by determining fluxes and intracellular concentrations in normal rats, methionine sulphoximine-treated rats and pair-fed controls. Moreover, fluxes and intracellular concentrations of several other...
Articles
Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (3): 337–342.
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
Articles
Electron paramagnetic resonance spectroscopy of stable free radicals in the liver compared with ultrastructural and functional damage in a rat model of alcohol- and iron-overload
Available to PurchaseGraham P. Butcher, Nigel Deighton, Roger M. Batt, Boliang Ding, Susan Haywood, John Hoffman, Malcolm J. Jackson, Martyn C. R. Symons, Jonathan M. Rhodes
Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (3): 339–348.
Published: 01 March 1993
...Graham P. Butcher; Nigel Deighton; Roger M. Batt; Boliang Ding; Susan Haywood; John Hoffman; Malcolm J. Jackson; Martyn C. R. Symons; Jonathan M. Rhodes 1. Electron paramagnetic resonance spectroscopy was used to study free-radical signals in freeze-clamped frozen liver tissue from rats after a 1...
Articles
Studies of human zinc kinetics using the stable isotope 70 Zn
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Journal:
Clinical Science
Clin Sci (Lond) (1993) 84 (1): 113–117.
Published: 01 January 1993
...N. M. Lowe; A. Green; J. M. Rhodes; M. Lombard; R. Jalan; M. J. Jackson 1. The short-term (120 min) kinetics of Zn turnover has been studied in control subjects and patients with alcoholic liver disease after intravenous injection of 0.5 mg of 96.5% enriched 70 ZnCl 2 . 2. The 70 Zn enrichment...
Articles
Evidence for the indirect utilization of glucose for the synthesis of hepatic glycogen in man
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (6): 677–682.
Published: 01 December 1992
...R. F. G. J. King; M. Madan; D. Alexander; A. Boyd; K. Ibrahim; M. J. McMahon; D. Johnston 1. This study was designed to test the hypothesis that three-carbon intermediates can be used in the ‘indirect’ pathway of glycogen synthesis in human liver (i.e. a route additional to the use of glucose...
Articles
Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs
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Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (5): 607–614.
Published: 01 November 1992
... area is less well characterized. We were specifically interested in substrate flux across the spleen as it is an organ with important immunological functions. 2. Therefore, hindquarter, gut, spleen and liver fluxes of amino acids, ammonia, glucose, lactate and blood gases were measured for 4 days after...
Articles
Effects of endothelin in portal hypertensive rats
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (2): 165–170.
Published: 01 August 1992
... 1992 blood pressure liver portal pressure splanchnic bed vascular reactivity Clinical Science (1992) 83, 165-170 (Printed in Great Britain) I65 Effects of endothelin in portal hypertensive rats PiChin YU', Jon-Son KUOz, HanChieh LIN3 and May C. M. YANG' 'Department of Medical Research...
Articles
Effect of l-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo
Available to PurchaseP. C. Dagnelie, D. K. Menon, I. J. Cox, J. D. Bell, J. Sargentoni, G. A. Coutts, J. Urenjak, R. A. Iles
Journal:
Clinical Science
Clin Sci (Lond) (1992) 83 (2): 183–190.
Published: 01 August 1992
...P. C. Dagnelie; D. K. Menon; I. J. Cox; J. D. Bell; J. Sargentoni; G. A. Coutts; J. Urenjak; R. A. Iles 1. 31 P n.m.r. spectroscopy in vivo was used to study the effect of l -alanine infusion on the concentrations of gluconeogenic intermediates in normal human liver. Studies were performed in six...
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