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Keywords: liver disease
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Clin Sci (Lond) (2019) 133 (3): 465–481.
Published: 12 February 2019
... mortality of chronic liver disease (CLD) with skeletal muscle depletion. Yet it is still not clear whether low muscle mass is a cause, an aggravating factor, a consequence of the ongoing disease, or an epiphenomenon reflecting general alteration in the critically ill patient. The mechanisms by which the...
Clin Sci (Lond) (2018) 132 (2): 199–212.
Published: 19 January 2018
...Peter Stärkel; Sophie Leclercq; Philippe de Timary; Bernd Schnabl Alcohol dependence and alcoholic liver disease represent a major public health problem with substantial morbidity and mortality. By yet incompletely understood mechanisms, chronic alcohol abuse is associated with increased intestinal...
Clin Sci (Lond) (2013) 124 (2): 77–85.
Published: 12 September 2012
... 2013 hepatitis B virus (HBV) immunity immunobiology infection liver disease Infection with HBV (hepatitis B virus) is a major healthcare problem, with up to 400 million people affected worldwide. The infection accounts annually for approximately 1 million deaths from cirrhosis, liver...
Clin Sci (Lond) (2010) 118 (2): 99–113.
Published: 12 October 2009
..., London 2010 complement cytoprotection hyperbilirubinaemia immune system liver disease oxidative stress unconjugated bilirubin The complement system is an enzymatic cascade of approx. 30 serum proteins leading to the amplification of a specific humoral response. Activation and fixation...
Clin Sci (Lond) (2009) 117 (2): 49–65.
Published: 15 June 2009
...Hengli Tang; Henry Grisé HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a major causative agent of liver disease, resulting in acute and chronic infections that can lead to fibrosis, cirrhosis and hepatocellular carcinoma. Hepatitis C represents the leading...
Includes: Multimedia, Supplementary data
Clin Sci (Lond) (2008) 114 (9): 567–588.
Published: 02 April 2008
... design of new successful therapeutic approaches to cholestatic liver diseases. Ntcp [ 28 – 31 ], Oatp1a1 [ 28 , 31 , 32 ] and Oatp1b2 [ 33 ] protein levels are decreased in several animal models of experimental cholestasis at a transcriptional level [ 34 ]. This helps to maintain at a minimum the...
Clin Sci (Lond) (2008) 114 (7): 457–466.
Published: 29 February 2008
... mediated by NKT cells, it has become increasingly apparent that NKT cells may fulfil both beneficial (e.g. clearance of virally infected cells) and harmful (e.g. induction of autoimmunity) roles in the setting of liver disease. This review will outline the possible roles which may be played by NKT cells in...
Clin Sci (Lond) (1992) 83 (3): 353–356.
Published: 01 September 1992
...Samina Rafique; Marianna Guardascione; Elsir Osman; Andrew K. Burroughs; James S. Owen 1. S -Adenosyl- l -methionine is reported to improve serum liver function tests in chronic liver disease. Because liver disease is complicated by cholesterol deposition in hepatic and extrahepatic membranes, we...
Clin Sci (Lond) (1992) 82 (4): 439–446.
Published: 01 April 1992
... glycoforms in sera from patients with various liver diseases and after liver transplantation. 2. Studies by isoelectric focusing and immunoblotting and by crossed immunoelectrophoresis without concanavalin A in the first dimension allowed us to show that there is no dramatic variation in electrophoretic...
Clin Sci (Lond) (1991) 80 (2): 155–160.
Published: 01 February 1991
... Indocyanine Green liver disease pharmacokinetics Clinical Science (1991) 80,155-160 155 Indocyanine Green elimination in patients with liver disease and in normal subjects E. BURNS, D. R. TRIGER, G. T. TUCKER AND N. D. S. BAX Department of Medicine and Pharmacology, University of Sheffield, Sheffield...
Clin Sci (Lond) (1988) 74 (4): 377–384.
Published: 01 April 1988
... excretion was otherwise unchanged. 5. In the patients with liver disease there were significant linear correlations between the degree of hepatocellular dysfunction and the serum caffeine elimination half-life ( r = 0.774; P < 0.01) and the total recovery of methylxanthine metabolites in the urine, in...
Clin Sci (Lond) (1987) 73 (5): 531–534.
Published: 01 November 1987
...L. J. Levy; J. Leek; M. S. Losowsky 1. Gas–liquid chromatography and a radioreceptor assay were used to measure plasma γ-aminobutyric acid (GABA) in patients with liver disease and hepatic encephalopathy. 2. There was a significant correlation between the results obtained by the two methods, and...
Clin Sci (Lond) (1985) 68 (6): 701–707.
Published: 01 June 1985
... acute and chronic liver disease. 2. In 21 patients with fulminant hepatic failure on admission in grade III or IV coma the plasma FPA, Bβ1-42, βTG and PF4 levels were significantly increased compared with those in normal control subjects. On heparinization before haemoperfusion the FPA levels returned...
Clin Sci (Lond) (1979) 57 (6): 499–508.
Published: 01 December 1979
...L. R. Engelking; S. Barnes; C. A. Dasher; D. C. Naftel; B. I. Hirschowitz 1. The serum bile acid disappearances of tracer doses of [24- 14 C]cholic acid and [1- 14 C]-glycocholic acid were studied in eight normal subjects and 11 patients with chronic liver disease (with or without cholestasis) in...
Clin Sci Mol Med (1978) 54 (5): 549–553.
Published: 01 May 1978
... hyperbilirubinaemia liver disease lysosomes melanin mitochondria superoxide dismutase Clinical Science and Molecular Medicine (1978) 54,549-553 The organelle pathology and demonstration of mitochondrial Superoxide dismutase deficiency in two patients with Dubin-Johnson-Sprinz syndrome T. J. PETERS AND CAROL A...
Clin Sci Mol Med (1976) 50 (1): 15–23.
Published: 01 January 1976
... arterial hypoxaemia or other complications (e.g. anaemia or shock), which may reduce cerebral oxygen delivery. 2 8 1975 © 1976 The Biochemical Society and the Medical Research Society 1976 anoxaemia anoxia brain liver disease Clinical Science and Molecular Medicine (1976) 50, 15-23...
Clin Sci Mol Med (1976) 50 (1): 25–35.
Published: 01 January 1976
... Society 1976 anoxaemia chemoreceptors liver cirrhosis liver disease respiration respiratory centre Clinical Science and Molecular Medicine (1976) SO, 25-35. Effect of liver failure on the ventilatory response to hypoxia in man and the goat N. N. STANLEY, S. G. KELSEN AND N. S. CHERNIACK...
Clin Sci Mol Med (1975) 49 (6): 603–608.
Published: 01 December 1975
...J. Dow; N. Krasner; A. Goldberg 1. Hepatic alcohol dehydrogenase activity and leucocyte ascorbic acid content were measured in thirty-five patients with liver disease and in ten control subjects with duodenal ulcer. The patients with liver disease were divided into three groups consisting of non...
Clin Sci Mol Med (1974) 47 (4): 359–366.
Published: 01 October 1974
...A. Wu; D. B. Grant; Judy Hambley; A. J. Levi 1. Somatomedin (SM; sulphation factor) activity was estimated by a chick-cartilage assay in fasting sera from twenty-one patients with chronic liver disease. 2. Low SM values were found in nine out of the ten patients with cirrhosis and in two other...