... hydrodynamic tail vein injection Liver cancer liver fibrosis liver injury thioacetamide National Health and Medical Research Council (NHMRC) 501100000925 APP1124125 Primary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer death [ 1...

... of AB administration to cholestatic patients should be evaluated in a systematic manner. bile acids Cyp2c70 gut microbiota hepatobiliary disease hydrophobicity liver fibrosis Correspondence: Jan Freark de Boer ( [email protected] ) or Folkert Kuipers ( [email protected]...

... A–C) and the onset of liver fibrosis, as evidenced by intrahepatic collagen staining with Sirius Red ( Figure 2 D). Interestingly, mice treated with hrAnxA1 showed significant decrease in the transcripts for procollagen-1α and TGF-1β ( Figure 2 A–C), along with a lower Sirius Red staining, than those...

..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...

... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...

... of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intrahepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented a direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker...

... of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity. Correspondence: Benjamin Leporq ( [email protected] ) 13 06 2017 05 02 2018 09 02...

[email protected] ) 21 06 2017 30 06 2017 07 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cirrhosis drug-induced liver injury liver fibrosis mouse models The liver fulfills crucial functions in energy homeostasis...

... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...

.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. • Homocysteine plays a role in vasoresponsiveness and angiogenesis in cardiovascular disease, but its effects in liver cirrhosis have not been determined. • In the present study, homocysteine enhanced...

... inflammation up to the development of overt fibrosis [ 19 ]. chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease • In healthy livers, DCs (dendritic cells) represent a small fraction of non-parenchymal cells and have a predominantly...

...Zhaoyong Yan; Kai Qu; Jing Zhang; Qichao Huang; Ping Qu; Xinsen Xu; Peng Yuan; Xiaojun Huang; Yongping Shao; Chang Liu; Hongxin Zhang; Jinliang Xing Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its...

... [email protected] ). 31 5 2012 27 7 2012 12 9 2012 12 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 liver fibrosis liver inflammation natural killer T-cell (NKT cell) non-alcoholic fatty liver disease • NF-κB activation...

...°C for RNA and protein extraction. A portion of the liver was immediately fixed in formalin for histological analyses, and another portion was processed for determination of oxidative-stress-related products (see below). CC chemokine ligand 2 chemokine cytokine liver fibrosis non-alcoholic...

...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...

... [email protected] ). 7 1 2011 11 3 2011 18 3 2011 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction In Western industrialized countries...

... time–density curves were fitted with a dual-input one-compartmental model to calculate the hepatic mean transit time and distribution volume of the contrast agents. In the rabbits with liver fibrosis, the mean transit time of the high-molecular-mass agent was shorter than that of the low-molecular-mass...

...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...

...J. P. Iredale; S. Goddard; G. Murphy; R. C. Benyon; M. J. P. Arthur 1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade...