... with the modulation of their phenotype. Treatment with hrAnxA1, in fact, reduces the production of the profibrogenic mediator such Gal-3 and OPN that have been previously shown to contribute to liver fibrosis in NASH [ 27 , 28 ]. Moreover, hrAnxA1 affects macrophage capacity of forming crown-like aggregates...

..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...

... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...

... of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intrahepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented a direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker...

... of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity. Correspondence: Benjamin Leporq ( benjamin.leporq2@gmail.com ) 13 06 2017 05 02 2018 09 02...

...@ki.se ) 21 06 2017 30 06 2017 07 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cirrhosis drug-induced liver injury liver fibrosis mouse models The liver fulfills crucial functions in energy homeostasis...

... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...

.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. Correspondence: Dr Hui-Chun Huang (email hchuang2@vghtpe.gov.tw ; hchuang2@gmail.com ) or Dr Fa-Yauh Lee (email fylee@vghtpe.gov.tw ) 1 Hung-Chun Tung and Shao-Jung Hsu contributed equally...

...-alcoholic steatohepatitis). chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease Previous studies have revealed the existence of at least two di-stinct monocyte subsets. Inflammatory monocytes are characte-rized as Ly6C high /CCR2...

...Zhaoyong Yan; Kai Qu; Jing Zhang; Qichao Huang; Ping Qu; Xinsen Xu; Peng Yuan; Xiaojun Huang; Yongping Shao; Chang Liu; Hongxin Zhang; Jinliang Xing Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its...

... 7 2012 12 9 2012 12 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 liver fibrosis liver inflammation natural killer T-cell (NKT cell) non-alcoholic fatty liver disease • NF-κB activation is involved in the pathogenesis of NASH. Among...

... cytokine liver fibrosis non-alcoholic steatohepatitis NAFLD (non-alcoholic fatty liver disease) is the most common cause of chronic liver disease in the Western world [ 1 ]. A fraction of patients with NAFLD shows findings of NASH (non-alcoholic steatohepatitis), which is characterized...

...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...

... from Biosciences Pharmingen. A rabbit polyclonal antibody against Ln-5 γ2 chain (used at 1:100) was a gift from Professor S. Sapo (Department of Biochemistry, University of Oulu, Oulu, Finland). cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction...

... time–density curves were fitted with a dual-input one-compartmental model to calculate the hepatic mean transit time and distribution volume of the contrast agents. In the rabbits with liver fibrosis, the mean transit time of the high-molecular-mass agent was shorter than that of the low-molecular-mass...

...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...

...J. P. Iredale; S. Goddard; G. Murphy; R. C. Benyon; M. J. P. Arthur 1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade...