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Keywords: liver fibrosis
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Clin Sci (Lond) (2024) 138 (19): 1227–1248.
Published: 26 September 2024
... hydrodynamic tail vein injection Liver cancer liver fibrosis liver injury thioacetamide National Health and Medical Research Council (NHMRC) 501100000925 APP1124125 Primary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer death [ 1...
Includes: Supplementary data
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Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... A–C) and the onset of liver fibrosis, as evidenced by intrahepatic collagen staining with Sirius Red ( Figure 2 D). Interestingly, mice treated with hrAnxA1 showed significant decrease in the transcripts for procollagen-1α and TGF-1β ( Figure 2 A–C), along with a lower Sirius Red staining, than those...
Includes: Supplementary data
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Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...
Includes: Supplementary data
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Clin Sci (Lond) (2018) 132 (24): 2565–2582.
Published: 13 December 2018
... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...
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Clin Sci (Lond) (2018) 132 (15): 1645–1667.
Published: 14 August 2018
... of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intrahepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented a direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (15): 2059–2062.
Published: 20 July 2017
[email protected] ) 21 06 2017 30 06 2017 07 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cirrhosis drug-induced liver injury liver fibrosis mouse models The liver fulfills crucial functions in energy homeostasis...
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Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...
Includes: Supplementary data
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Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. • Homocysteine plays a role in vasoresponsiveness and angiogenesis in cardiovascular disease, but its effects in liver cirrhosis have not been determined. • In the present study, homocysteine enhanced...
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Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
... inflammation up to the development of overt fibrosis [ 19 ]. chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease • In healthy livers, DCs (dendritic cells) represent a small fraction of non-parenchymal cells and have a predominantly...
Includes: Supplementary data
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Clin Sci (Lond) (2015) 129 (8): 699–710.
Published: 22 July 2015
...Zhaoyong Yan; Kai Qu; Jing Zhang; Qichao Huang; Ping Qu; Xinsen Xu; Peng Yuan; Xiaojun Huang; Yongping Shao; Chang Liu; Hongxin Zhang; Jinliang Xing Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...
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Clin Sci (Lond) (2011) 121 (4): 159–168.
Published: 28 April 2011
... [email protected] ). 7 1 2011 11 3 2011 18 3 2011 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction In Western industrialized countries...
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Clin Sci (Lond) (1997) 92 (2): 103–112.
Published: 01 February 1997
...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...
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