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Keywords: liver fibrosis
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Articles
Oncogenic plasmid DNA and liver injury agent dictates liver cancer development in a mouse model
Open AccessVincent Chiu, Christine Yee, Nathan Main, Igor Stevanovski, Matthew Watt, Trevor Wilson, Peter Angus, Tara Roberts, Nicholas Shackel, Chandana Herath
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (19): 1227–1248.
Published: 26 September 2024
... hydrodynamic tail vein injection Liver cancer liver fibrosis liver injury thioacetamide National Health and Medical Research Council (NHMRC) 501100000925 APP1124125 Primary liver cancer is the sixth most common cancer worldwide and the third leading cause of cancer death [ 1...
Includes: Supplementary data
Articles
In Collection
New discoveries in bile acids, gut microbiota and host interactions in health and diseases
Esther Verkade, Wenqiang Shen, Milaine V. Hovingh, Niels L. Mulder, Krisztina de Bruyn, Martijn Koehorst, Hilde D. de Vries, Vincent W. Bloks, Folkert Kuipers, Jan Freark de Boer
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (21): 1637–1650.
Published: 10 November 2023
... of AB administration to cholestatic patients should be evaluated in a systematic manner. bile acids Cyp2c70 gut microbiota hepatobiliary disease hydrophobicity liver fibrosis Correspondence: Jan Freark de Boer ( [email protected] ) or Folkert Kuipers ( [email protected]...
Includes: Supplementary data
Articles
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis
Available to PurchaseLaila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... A–C) and the onset of liver fibrosis, as evidenced by intrahepatic collagen staining with Sirius Red ( Figure 2 D). Interestingly, mice treated with hrAnxA1 showed significant decrease in the transcripts for procollagen-1α and TGF-1β ( Figure 2 A–C), along with a lower Sirius Red staining, than those...
Includes: Supplementary data
Articles
Cyclin-dependent kinase inhibitor roscovitine attenuates liver inflammation and fibrosis by influencing initiating steps of liver injury
Available to PurchaseYanjun Liu, Jiacheng Li, Liping Liao, Heming Huang, Shijie Fan, Rong Fu, Jing Huang, Cuicui Shi, Liang Yu, Kai-xian Chen, Yuan-yuan Zhang, Cheng Luo, Guang-ming Li
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (7): 925–941.
Published: 14 April 2021
..., accompanied with reduced liver fibrosis. The anti-fibrotic mechanism involved inhibition of profibrotic genes and blocking of hepatic stellate cell (HSC) activation. Our data show that roscovitine administration protects against liver diseases through inhibition of macrophage inflammatory actions and HSC...
Includes: Supplementary data
Articles
Type 3 innate lymphoid cell: a new player in liver fibrosis progression
Available to PurchaseSiqi Wang, Jing Li, Shengdi Wu, Lisha Cheng, Yue Shen, Wei Ma, Weimin She, Changqing Yang, Jiyao Wang, Wei Jiang
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (24): 2565–2582.
Published: 13 December 2018
... in liver fibrosis. By flow cytometry, we documented increased frequencies of peripheral ILC3 (Lin − CD127 + CD117 + CD294 − lymphocytes) in patients, especially at the advanced stage of hepatitis B virus (HBV)-related chronic liver diseases, and demonstrated their correlations with disease progression...
Articles
HMGB1-induced autophagy facilitates hepatic stellate cells activation: a new pathway in liver fibrosis
Available to PurchaseJing Li, Chuxiong Zeng, Beishi Zheng, Chun Liu, Min Tang, Yan Jiang, Yizhong Chang, Weiping Song, Yingxin Wang, Changqing Yang
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (15): 1645–1667.
Published: 14 August 2018
... of HMGB1-induced HSCs autophagy in liver fibrosis has not been elucidated. Here, we first documented an enrichment of peripheral and intrahepatic HMGB1 signal in hepatitis B virus (HBV)-related liver fibrosis progression, and presented a direct evidence of anatomic proximity of HMGB1 with a-SMA (a marker...
Includes: Supplementary data
Articles
Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease
Available to PurchaseBenjamin Leporq, Jean-Luc Daire, Catherine M. Pastor, Pierre Deltenre, Christine Sempoux, Sabine Schmidt, Bernard E. Van Beers
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (7): 813–824.
Published: 16 April 2018
... of hepatic perfusion and hepatocyte function is feasible with free breathing dynamic gadoxetic acid-enhanced MRI. Hepatocyte function parameters may be relevant to assess liver fibrosis severity. Correspondence: Benjamin Leporq ( [email protected] ) 13 06 2017 05 02 2018 09 02...
Includes: Supplementary data
Articles
Dysregulation of miR-223 constitutes a promising biomarker that informs about clinical outcomes of acute liver failure
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2059–2062.
Published: 20 July 2017
[email protected] ) 21 06 2017 30 06 2017 07 07 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 cirrhosis drug-induced liver injury liver fibrosis mouse models The liver fulfills crucial functions in energy homeostasis...
Articles
miR-223 represents a biomarker in acute and chronic liver injury
Available to PurchaseFlorian Schueller, Sanchari Roy, Sven Heiko Loosen, Jan Alder, Christiane Koppe, Anne Theres Schneider, Franziska Wandrer, Heike Bantel, Mihael Vucur, Qing-Sheng Mi, Christian Trautwein, Tom Luedde, Christoph Roderburg
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1971–1987.
Published: 13 July 2017
... in these models. Results: miR-223 expression was significantly dysregulated in livers from mice after induction of acute liver injury and liver fibrosis as well as in liver samples from patients with ALF or liver cirrhosis. In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes...
Includes: Supplementary data
Articles
Homocysteine deteriorates intrahepatic derangement and portal-systemic collaterals in cirrhotic rats
Available to PurchaseHung-Chun Tung, Shao-Jung Hsu, Ming-Hung Tsai, Te-Yueh Lin, I-Fang Hsin, Te-Ia Huo, Fa-Yauh Lee, Hui-Chun Huang, Hsin-Ling Ho, Han-Chieh Lin, Shou-Dong Lee
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (1): 69–86.
Published: 09 December 2016
.... In conclusion, homocysteine is harmful to vascular derangements and liver fibrosis in cirrhosis. • Homocysteine plays a role in vasoresponsiveness and angiogenesis in cardiovascular disease, but its effects in liver cirrhosis have not been determined. • In the present study, homocysteine enhanced...
Articles
CX 3 CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis
Available to PurchaseSalvatore Sutti, Irene Locatelli, Stefania Bruzzì, Aastha Jindal, Marco Vacchiano, Cristina Bozzola, Emanuele Albano
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
... inflammation up to the development of overt fibrosis [ 19 ]. chronic inflammation CX 3 CR1 dendritic cells liver fibrosis macrophages non-alcoholic fatty liver disease • In healthy livers, DCs (dendritic cells) represent a small fraction of non-parenchymal cells and have a predominantly...
Includes: Supplementary data
Articles
CD147 promotes liver fibrosis progression via VEGF-A/VEGFR2 signalling-mediated cross-talk between hepatocytes and sinusoidal endothelial cells
Available to PurchaseZhaoyong Yan, Kai Qu, Jing Zhang, Qichao Huang, Ping Qu, Xinsen Xu, Peng Yuan, Xiaojun Huang, Yongping Shao, Chang Liu, Hongxin Zhang, Jinliang Xing
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (8): 699–710.
Published: 22 July 2015
...Zhaoyong Yan; Kai Qu; Jing Zhang; Qichao Huang; Ping Qu; Xinsen Xu; Peng Yuan; Xiaojun Huang; Yongping Shao; Chang Liu; Hongxin Zhang; Jinliang Xing Although previous evidence indicates close involvement of CD147 in the pathogenesis of liver fibrosis, the underlying molecular mechanisms and its...
Includes: Supplementary data
Articles
NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (4): 279–287.
Published: 05 November 2012
... [email protected] ). 31 5 2012 27 7 2012 12 9 2012 12 9 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 liver fibrosis liver inflammation natural killer T-cell (NKT cell) non-alcoholic fatty liver disease • NF-κB activation...
Includes: Supplementary data
Articles
Sara Galastri, Elena Zamara, Stefano Milani, Erica Novo, Angela Provenzano, Wanda Delogu, Francesco Vizzutti, Salvatore Sutti, Irene Locatelli, Nadia Navari, Elisa Vivoli, Alessandra Caligiuri, Massimo Pinzani, Emanuele Albano, Maurizio Parola, Fabio Marra
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (7): 459–471.
Published: 07 June 2012
...°C for RNA and protein extraction. A portion of the liver was immediately fixed in formalin for histological analyses, and another portion was processed for determination of oxidative-stress-related products (see below). CC chemokine ligand 2 chemokine cytokine liver fibrosis non-alcoholic...
Articles
Update on new aspects of the renin–angiotensin system in liver disease: clinical implications and new therapeutic options
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (4): 225–239.
Published: 24 April 2012
...Josephine A. Grace; Chandana B. Herath; Kai Yan Mak; Louise M. Burrell; Peter W. Angus The RAS (renin–angiotensin system) is now recognized as an important regulator of liver fibrosis and portal pressure. Liver injury stimulates the hepatic expression of components of the RAS, such as ACE...
Articles
Hepatic stellate cells stimulate HCC cell migration via laminin-5 production
Available to PurchaseAngela Santamato, Emilia Fransvea, Francesco Dituri, Alessandra Caligiuri, Michele Quaranta, Tomoaki Niimi, Massimo Pinzani, Salvatore Antonaci, Gianluigi Giannelli
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (4): 159–168.
Published: 28 April 2011
... [email protected] ). 7 1 2011 11 3 2011 18 3 2011 18 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 cell motility extracellular matrix protein laminin liver fibrosis tumour–host interaction In Western industrialized countries...
Articles
Dynamic computed tomography with low- and high-molecular-mass contrast agents to assess microvascular permeability modifications in a model of liver fibrosis
Available to PurchaseRoland MATERNE, Laurence ANNET, Stéphane DECHAMBRE, Christine SEMPOUX, Anne M. SMITH, Claire COROT, Yves HORSMANS, Bernard E. VAN BEERS
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (2): 213–216.
Published: 19 July 2002
... time–density curves were fitted with a dual-input one-compartmental model to calculate the hepatic mean transit time and distribution volume of the contrast agents. In the rabbits with liver fibrosis, the mean transit time of the high-molecular-mass agent was shorter than that of the low-molecular-mass...
Articles
Pathogenesis of Liver Fibrosis
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (2): 103–112.
Published: 01 February 1997
...R. Alcolado; M. J. P. Arthur; J. P. Iredale 1. Liver fibrosis is a common sequel to diverse liver injuries. It is characterized by an accumulation of interstitial collagens and other matrix components. The hepatic stellate cell is pivotal to the pathogenic process. Fibrotic liver injury results...
Articles
Tissue Inhibitor of Metalloproteinase-1 and Interstitial Collagenase Expression in Autoimmune Chronic Active Hepatitis and Activated Human Hepatic Lipocytes
Available to Purchase
Journal:
Clinical Science
Clin Sci (Lond) (1995) 89 (1): 75–81.
Published: 01 July 1995
...J. P. Iredale; S. Goddard; G. Murphy; R. C. Benyon; M. J. P. Arthur 1. Activated hepatic lipocytes are central to the pathogenesis of liver fibrosis as the principal source of both interstitial collagens and matrix-degrading metalloproteinases. In progressive fibrosis there is a failure to degrade...