... to generate an aerosol of local anaesthetic in particles small enough to allow alveolar deposition. Lignocaine (2% and 5%) produced aerosols with an arithmetic mean diameter (+sd) of 1.5+0.3 and 1.2+0.6 μm respectively, the mass median diameters being 1.7 (geometric standard deviation = 1.2) and 2.5...

..., intracerebroventricular ad- ministration, local anaesthetics, optical isomers. Introduction The anti-hypertensive effects of clonidine and u- methyldopa are thought to be mediated via stimu- lation of central a-adrenoceptors, causing a re- duction in activity of the sympathetic nerves to the heart and vasculature...