...Ying-Ying Yang; Pei-Chang Lee; Yi-Tsau Huang; Wei-Ping Lee; Ying-Ju Kuo; Kuei-Chuan Lee; Yun-Cheng Hsieh; Tzung-Yan Lee; Han-Chieh Lin Besides cardioprotective effects, the AT 1 R (angiotensin-II type 1 receptor) antagonist losartan protects the liver from IRI [IR (ischaemia/reperfusion) injury...

...Virginia CHAMORRO; Rosemary WANGENSTEEN; Juan SAINZ; Juan DUARTE; Francisco O'VALLE; Antonio OSUNA; Félix VARGAS The present study evaluates the participation of oxidative stress, tissue angiotensin II (Ang II) and endothelin (ET) in the effects of losartan on blood pressure (BP), ventricular...

... whether this effect may be mediated by the decreased action of angiotensin, we compared the effects of enalapril with the direct angiotensin-II antagonist, losartan, on plasma levels of cAMs, and monocyte chemotactic protein-1 (MCP-1). In a randomized trial, we recruited 32 untreated patients (19 male...

... losartan. Male Sprague–Dawley rats (250–300 g) were gavaged with either irbesartan or losartan at doses of 1, 3, 10, 30 or 100 mg/kg, or with corresponding vehicle. Rats were killed at 0, 1, 2, 8, or 24 h after drug administration, trunk blood was collected and the kidneys were removed. The effects...

... further investigation in order to clarify the role of angiotensin II. Pregnant rats were fed a control diet containing 18% (w/w) casein as the protein source or a low-protein diet containing 9% (w/w) casein. Between the ages of 2 and 4 weeks postnatally, mothers and their pups were treated with losartan...

...R. J. MacFadyen; M. Tree; A. F. Lever; J. L. Reid 1. Haemodynamic and hormonal responses to infused angiotensin II were studied in conscious salt-deplete dogs during infusion of D-glucose or losartan (DuP753/MK954). 2. Mean arterial pressure (118±13mmHg) fell rapidly after losartan (60 min 106±18...