.... Lysine potently inhibits tubular peptide uptake, and may thus depress the uptake and metabolism of aprotinin. This was investigated in 14 glomerulonephritic patients with normal renal function and variable proteinuria and in one healthy subject. 2. 99m Tc-labelled aprotinin was given intravenously alone...

... volunteers before and during blockade of tubular protein reabsorption by intravenous infusion of either l -arginine hydrochloride ( n = 8; 0.5 g h −1 kg −1 body weight) or an equimolar amount of l -lysine hydrochloride ( n = 5; 0.44 g h −1 kg −1 body weight). Glomerular filtration rate was measured...

...F. C. Fervenza; C. M. Harvey; B. M. Hendry; J. C. Ellory 1. The initial rate of l -lysine influx into erythrocytes from 13 patients with chronic renal failure has been measured using 14 C-labelled lysine. Ten patients were on maintenance haemodialysis and three had never been dialysed. The results...

... of the basic amino acid lysine increased the urinary renin concentration, renin excretion rate and renin clearance two to three orders of magnitude, without affecting the plasma renin concentration. 4. This finding demonstrates that ultrafiltered renin is reabsorbed almost completely in the renal tubules...

... 1984 5 9 1984 © 1985 The Biochemical Society and the Medical Research Society 1985 alanine amino acid aspartate glutamate glutamine glycine leucine lysine man 15 N nitrogen turnover protein absorption protein synthesis wheat whole body yeast Clinical Science (1985...