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Keywords: lysosomes
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Clin Sci (Lond) (1981) 60 (2): 207–212.
Published: 01 February 1981
...J. Scott; W. Jenkins; G. P. Smith; T. J. Peters 1. Analytical subcellular fractionation in combination with enzymic microanalysis has been used to investigate the hepatic organelle pathology of primary biliary cirrhosis. Activities of plasma membrane and lysosomal enzymes in hepatic needle biopsies...
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Clin Sci (Lond) (1980) 59 (6): 457–462.
Published: 01 December 1980
... a major peak (modal density, 1.17) with a small subsidiary peak (modal density 1.24). 3. The following organelles, characterized by their marker enzymes, were located in the density gradients; plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes (β- N...
Articles
Clin Sci (Lond) (1980) 59 (1): 7–12.
Published: 01 July 1980
...T. J. Peters; W. Jenkins; V. Dubowitz 1. An homogenate of liver biopsy taken from a patient with Pompe's disease (type II glycogen-storage disease) was analysed by enzyme microassay and subcellular fractionation by sucrose-density-gradient centrifugation. 2. A strikingly low activity of lysosomal...
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Clin Sci (Lond) (1980) 59 (1): 1–6.
Published: 01 July 1980
... density 1.18) and a substantial shoulder extending into the denser regions of the gradient. 3. The following organelles, characterized by their marker enzymes, were located in the density gradients: plasma membrane (5′-nucleotidase), mitochondria (malate dehydrogenase), peroxisomes (catalase), lysosomes...
Articles
Clin Sci (Lond) (1980) 58 (2): 165–168.
Published: 01 February 1980
...P. Maury; J. Palo 1. Aspartylglycosaminuria is a neurovisceral storage disease characterized by reduced or absent activity of the lysosomal enzyme N -aspartyl-β-glucosaminidase. Although vacuolization of peripheral lymphocytes is a well-documented feature of aspartylglucosaminuria, the chemical...
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Articles
Clin Sci (Lond) (1979) 56 (5): 479–486.
Published: 01 May 1979
... of the organelle was normal. Homogenization studies revealed that the brush border was unusually fragile. 4. Apart from reduced activities of the basal—lateral marker enzyme 5′-nucleotidase and enhanced lysosomal fragility, other organelles showed normal properties. There were no significant differences in any...
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Clin Sci Mol Med (1978) 55 (4): 383–389.
Published: 01 October 1978
...Carol A. Seymour; T. J. Peters 1. Liver biopsy specimens obtained from patients with alcoholic liver disease of varying severity were assayed for lysosomal and microsomal enzyme activities, the results being compared with values previously obtained in control subjects. 2. Analytical subcellular...
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Clin Sci Mol Med (1978) 54 (5): 549–553.
Published: 01 May 1978
... hyperbilirubinaemia liver disease lysosomes melanin mitochondria superoxide dismutase Clinical Science and Molecular Medicine (1978) 54,549-553 The organelle pathology and demonstration of mitochondrial Superoxide dismutase deficiency in two patients with Dubin-Johnson-Sprinz syndrome T. J. PETERS AND CAROL...
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Clin Sci Mol Med (1977) 53 (6): 551–562.
Published: 01 December 1977
.... Key words: brush borders, cytosol, duodenum, enterokinase, lysosomes, microvillous mem- branes, mitochondria, subcellular fractionation. Correspondence: Dr R. Holmes, University Depart- ment of Gastroenterology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, U.K. Introduction...
Articles
Clin Sci Mol Med (1977) 53 (1): 63–74.
Published: 01 July 1977
... content, were resolved by density gradient centrifugation in a small-volume zonal rotor. The equilibrium densities ( p ) of the principal organelles are (with marker enzymes in parentheses): sarcolemma, 1·12 (5′-nucleotidase); lysosomes, 1·16 ( N -acetyl-β-glucosaminidase); mitochondria, 1·17 (cytochrome...
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Clin Sci Mol Med (1977) 52 (3): 241–248.
Published: 01 March 1977
... fractionation experiments demonstrate that the lysosomes, which have strikingly reduced equilibrium densities, accumulate melanin. Morphological studies confirm the presence of pigments within lysosomes. 3. Although there are increased activities of lysosomal acid hydrolases in the liver tissue from patients...
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Clin Sci Mol Med (1976) 51 (6): 557–574.
Published: 01 December 1976
... densities in sucrose density gradients: brush borders (1·21), peroxisomes (1·18), mitochondria (1·16), endoplasmic reticulum (1·16), basal—lateral membranes (1·12). At least three distinct populations of lysosomes with different modal densities and enzyme content were demonstrated. 5. This analytical...
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Clin Sci Mol Med (1976) 50 (1): 75–78.
Published: 01 January 1976
...T. J. Peters; Carol A. Seymour 1. Iron, acid phosphatase and N -acetyl-β-glucosaminidase were assayed in liver biopsies from control subjects and patients with primary and secondary haemochromatosis. 2. The activities of the lysosomal enzymes were significantly higher in liver biopsies from...
Articles
Clin Sci Mol Med (1975) 49 (2): 171–182.
Published: 01 August 1975
... The Biochemical Society and the Medical Research Society 1975 granulocytes leucocytes lysosomes microsomes mitochondria plasma membranes subcellular fractionation vitamin B 12 vitamin B 12 -binding proteins Clinical Science and Molecular Medicine (1975) 49, 171-1 82 Analytical subcellular...
Articles
Clin Sci Mol Med (1975) 48 (4): 307–313.
Published: 01 April 1975
... in activity after bile-duct ligation. 4. No changes in mitochondrial enzyme activities were noted after 1 day but there was a 50% reduction 8 days after ligation. Lysosomal enzyme activities did not change in the liver tissue. 5. Liver catalase and d-amino acid oxidase activities showed a slight increase at 1...
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Clin Sci (1972) 42 (4): 405–414.
Published: 01 April 1972
... acid (pteroylglutamic acid) pteroylpolyglutamates folate conjugase (pteroylpolyglutamate hydrolase) oral contraceptives lysosomes Clinical Science (1972) 42,405-414. ORAL CONTRACEPTIVES A N D FOLATE METABOLISM M. E. M. STEPHENS, I. CRAFT, T. J . PETERS A N D A . V. H O F F B R A N D Department...