Skip Nav Destination
Close Modal
1-50 of 30980
Keywords: mTOR
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
1
Articles
Articles
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 1: Identification and characterization of exosomes derived from human plasma and OCs after lead (Pb) exposure. (A ) Schematic diagram of designing population and osteoclast. Plasma and bone mineral density were collected from individuals with or without Pb exposure. Patients were divided ... More about this image found in Identification and characterization of exosomes derived from human plasma a...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 2: Profiling of miRNAs in plasma/OC-Exos and selection of exosomal miR-30a-3p. (A ) Schematic diagram of the sequencing design of plasma-Exos and OC-Exos. Plasma-Exos from Pb-exposed low-BMD (group A), Pb-exposed normal BMD (group B), low BMD (group C), and healthy control (group D) group... More about this image found in Profiling of miRNAs in plasma/OC-Exos and selection of exosomal miR-30a-3p....
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 3: Reduced bone formation and elevated plasma exosomal miR-30a-3p in SD rats after treating with PbAc. ( A ) Schematic diagram illustrating the experimental design. Plasma and bone samples were collected after the SD rats were gavaged with 2 mg/ml PbAc, 4 mg/ml PbAc, 8 mg/ml PbAc, 0.4 mg/m... More about this image found in Reduced bone formation and elevated plasma exosomal miR-30a-3p in SD rats a...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 4: The osteoclast (OC)-derived exosomal miR-30a-3p secreted from Pb-treated OCs inhibits bone formation in vivo . Exosomes isolated from NC/OCs/Pb-treated osteoclasts/(Anti-miR-30a-3 P +Pb)-treated OCs were intravenously injected into SD rats, which were designated as NC-Exo, OC-Exo, Pb-O... More about this image found in The osteoclast (OC)-derived exosomal miR-30a-3p secreted from Pb-treated OC...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 5: Pb-treated OCs secrete Exo-packaged miR-30a-3p and induce pyroptosis in OBs. ( A ) Scheme of experiment. OCs were transfected with the FAM-tagged miR-30a-3p mimic to generate OCs-FAM-miR-30a-3p and were co-cultured with OBs in a 0.4-μm transwell plate. The transfection was confirmed by ... More about this image found in Pb-treated OCs secrete Exo-packaged miR-30a-3p and induce pyroptosis in OBs...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 6: OC-Exo-miR-30a-3p is responsible for the pyroptosis of OBs. OCs were transfected with NC or miR-30a-3p inhibitor and then exposed to Pb and co-cultured with OBs, namely, NC-OC, (NC+Pb)-OC, and (Anti-30a-3 P +Pb)-OC. The co-culture of OBs with OC transfected miR-30a-3p mimic or non-treat... More about this image found in OC-Exo-miR-30a-3p is responsible for the pyroptosis of OBs. OCs were trans...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Figure 7: OC-Exo-miR-30a-3p induces pyroptosis in osteoblasts (OBs) via an NF-κB-dependent pathway, and this pyroptosis induction in OBs also enhances the proliferation of osteoclasts (OCs) in a positive-feedback manner. ( A ) The potential target genes containing the miR-30a-3p seed sequence wer... More about this image found in OC-Exo-miR-30a-3p induces pyroptosis in osteoblasts (OBs) via an NF-κB-depe...
Images
in Osteoclast-derived exosomal miR-30a-3p promotes lead exposure-induced osteoporosis by triggering osteoblastic pyroptosis
> Clinical Science
Published: 10 April 2025
Scheme 1: The expression of exosome miR-30a-3p was up-regulated in the lead (Pb)-exposed group, suggesting that the abnormal expression of exosome miR-30a-3p derived from osteoclasts may be involved in the Pb-exposed group. After Pb treatment, miR-30a-3p was up-regulated in OCs. In cell-to-cell c... More about this image found in The expression of exosome miR-30a-3p was up-regulated in the lead (Pb)-expo...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (07): 373–387.
Published: 09 April 2025
Includes: Supplementary data
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 1: CGRP expression levels are elevated in patients with ARDS and in experimental models of ARDS. ( A ) ELISA was used to quantitatively evaluate blood CGRP levels in ARDS patients and controls (controls = 31, ARDS patients = 52). (B) Serum CGRP levels in patients with mild-to-moderate AR... More about this image found in CGRP expression levels are elevated in patients with ARDS and in experiment...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 2: CGRP attenuated LPS-induced lung injury. ( A,B ) CGRP expression in the lung. ( C) H&E staining (scale bar = 100 μm). ( D) Lung injury scores. ( E) Lung W/D weight ratio. ( F) Total protein levels in the BALF. * P < 0.05, ** P < 0.01. BALF, bronchoalveolar lavage fluid; ... More about this image found in CGRP attenuated LPS-induced lung injury. ( A,B ) CGRP expression in the lu...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 3: CGRP attenuates LPS-induced oxidative stress and inflammation. ( A ) RAW264.7 cells were treated with different concentrations of CGRP for 24 h, and the cell viability was calculated. ( B) RAW264.7 cells were treated with different concentrations of CGRP after LPS stimulation for 24 h,... More about this image found in CGRP attenuates LPS-induced oxidative stress and inflammation. ( A ) RAW26...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 4: CGRP attenuated LPS-induced apoptosis. ( A ) TUNEL staining of the lung (blue = nucleus, red = TUNEL, scale bar = 200 μm). ( B) The percentage of apoptotic RAW264.7 cells was detected via flow cytometry. CGRP, calcitonin gene-related peptide; LPS, lipopolysaccharide. More about this image found in CGRP attenuated LPS-induced apoptosis. ( A ) TUNEL staining of the lung (b...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 5: CGRP regulates the polarization balance of M1 (CD86)/M2 (CD206) macrophages in LPS-induced ARDS. ( A ) Immunofluorescence in the lung (blue = nucleus, red = CD206, green = CD86, scale bar = 200 μm). ( B) Flow cytometry was used to detect the proportion of M1 (CD86)/M2 (CD206) macrophag... More about this image found in CGRP regulates the polarization balance of M1 (CD86)/M2 (CD206) macrophages...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 6: Expression of RAMP1 and CGRP in the ARDS model. ( A ) RAMP1 expression in the lung (scale bar = 100 μm). (B,C) Protein expression of RAMP1 in the lung. (D,E) Protein expression of RAMP1 in RAW264.7 cells. ( F,G) Volcano plot showing the differentially expressed genes identified by ... More about this image found in Expression of RAMP1 and CGRP in the ARDS model. ( A ) RAMP1 expression in ...
Images
in CGRP alleviates lipopolysaccharide-induced ARDS inflammation via the HIF-1α signaling pathway
> Clinical Science
Published: 09 April 2025
Figure 7: CGRP alleviates LPS-induced ARDS through the HIF-1α pathway. ( A,B ) Protein expression of HIF-1α in the lung. ( C,D) Protein expression of HIF-1α in RAW264.7 cells. ( E) Immunofluorescence in the lung (blue = nucleus, red = CD206, green = CD86, scale bar = 200 μm). (F) H&E stai... More about this image found in CGRP alleviates LPS-induced ARDS through the HIF-1α pathway. ( A,B ) Prote...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (06): 357–372.
Published: 25 March 2025
Includes: Supplementary data
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 1: Differentially expressed mRNA and lncRNA based on RNA-seq analysis of abdominal aortic samples from patients (AAA) and healthy donors. ( A ) Volcano plot showing DE-mRNAs expression represented by dots found in AAA tissue samples versus donors (CT). Dots in blue denote DE-mRNAs with a ... More about this image found in Differentially expressed mRNA and lncRNA based on RNA-seq analysis of abdom...
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 2: Validation of differentially up-regulated lncRNAs in a large cohort of patients with AAA. ( A–I ) LncRNA up-regulated in the aorta from AAA patients ( n = 101) in comparison with donors ( n = 39) was confirmed by real-time PCR (qRT-PCR). The expression of lnRNAs was normalized to β-ac... More about this image found in Validation of differentially up-regulated lncRNAs in a large cohort of pati...
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 3: Diagnostic capacity assessment of selected lncRNAs. Receiver-operating characteristic (ROC) curve analysis evidences that the selected LncRNAs discriminate AAA patients ( n = 101) from the healthy controls ( n = 39). ( A ) ROC curves for the nine selected lncRNAs are shown. The table ... More about this image found in Diagnostic capacity assessment of selected lncRNAs. Receiver-operating cha...
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 4: The induction of ER stress in human VSMCs triggered the expression of specific lncRNAs. VSMCs were treated with by tunicamycin (1 μg/ml) in the presence or absence of TUDCA (500 μg/ml). The transcript levels of ATF4 ( A ), ATF6 ( B ), CHOP ( C ) , XBP1 ( D ), and those of the lncRNAs: ... More about this image found in The induction of ER stress in human VSMCs triggered the expression of speci...
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 5: The induction of ER stress in Jurkat T cells up-regulated the expression of specific lncRNAs. Jurkat T cells were treated with by tunicamycin (1 μg/ml) in the presence or absence of TUDCA (100 μg/ml). The transcript levels of ATF4 ( A ), ATF6 ( B ), CHOP ( C ), XBP1 ( D ), and those of ... More about this image found in The induction of ER stress in Jurkat T cells up-regulated the expression of...
Images
in Identification of endoplasmic reticulum stress-associated lncRNAs influencing inflammation and VSMC function in abdominal aortic aneurysm
> Clinical Science
Published: 25 March 2025
Figure 6: Comprehensive analysis of mRNA-lncRNA co-expression profile in AAA. ( A ) Number of differentially expressed mRNAs whose expression correlates with that of those lncRNAs related to ER stress and validated in the study. ( B ) Venn diagram showing the relationship between DEGs whose expre... More about this image found in Comprehensive analysis of mRNA-lncRNA co-expression profile in AAA. ( A ) ...
Articles
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 1: Body weight and kidney volume throughout study. Data presented in male lambs that underwent fetal sham surgery (sham; presented as two kidneys for kidney volume data), fetal uninephrectomy (C-SFK), and uninephrectomy at four weeks of age (EA-SFK). Data are mean±SEM. ( A ) Body weight at... More about this image found in Body weight and kidney volume throughout study. Data presented in male lam...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 2: Magnetic resonance imaging (MRI) phase-contrast renal artery flow at two months of age. ( A ) Renal artery blood flow (ml/min), ( B ) renal artery blood flow normalized to body weight (ml/min/kg), and ( C ) renal artery blood flow normalized to kidney volume (ml/min/cm³) at two months o... More about this image found in Magnetic resonance imaging (MRI) phase-contrast renal artery flow at two mo...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 3: Basal kidney hemodynamics at eight months of age. ( A ) Basal glomerular filtration rate (GFR), ( B ) renal blood flow (RBF), ( C ) renal vascular resistance (RVR), and ( D ) filtration fraction measured over 3 h presented as a singular average of this period. Data presented in male lam... More about this image found in Basal kidney hemodynamics at eight months of age. ( A ) Basal glomerular f...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 4: Cardiovascular and kidney hemodynamics responses to amino acid and dopamine (AA+D) infusion at eight months of age. ( A, B ) MAP, ( C, D ) GFR, ( E, F ) RBF, ( G, H ) FF, and ( I, J ) urinary protein excretion in response to AA+D infusion. Data presented in male lambs that underwent fet... More about this image found in Cardiovascular and kidney hemodynamics responses to amino acid and dopamine...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 5: Cardiovascular and kidney hemodynamic responses to NOS inhition at eigtht months of age. ( A, B ) MAP, ( C, D ) GFR, ( E, F ) RBF, and ( G, H ) FF in response to L-NAME. Data presented in male lambs that underwent fetal sham surgery (sham, n =6), fetal uninephrectomy (C-SFK, n =6), or... More about this image found in Cardiovascular and kidney hemodynamic responses to NOS inhition at eigtht m...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 6: Basal total urinary NOx at eight months of age. Data presented in male lambs that underwent fetal sham surgery (sham, n =6) , fetal uninephrectomy (C-SFK, n =6) , or uninephrectomy at four weeks of age (EA-SFK, n =8) . Data are mean±SEM. P values are from Tukey’s post hoc test afte... More about this image found in Basal total urinary NOx at eight months of age. Data presented in male lam...
Images
in Renal hypertrophy and hyperfiltration is enhanced in early acquired compared with a congenital solitary function kidney model in sheep
> Clinical Science
Published: 13 March 2025
Figure 7: Kidney histopathology and morphometry at eight months of age. (A ) Tubular injury score, ( B ) PAS+casts, ( C ) tubular dilation score, ( D ) kidney cortical fibrosis (% collagen), ( E ) glomerular size distribution (% glomeruli vs. glomerular size (µm²x10 3 ). ( F ) Representative mic... More about this image found in Kidney histopathology and morphometry at eight months of age. (A ) Tubula...
Articles
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (05): 235–338.
Published: 11 March 2025
Includes: Supplementary data
Images
in Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
> Clinical Science
Published: 11 March 2025
Figure 1: Influence of cardiomyocyte-specific deletion of Trbp on cardiac morphology and function in young adult mice. (A) Schematic representation of the timeline for analysis of Trbp deletion in young adult mice. TAC surgery was performed four weeks following TAM treatment. Echocardiography w... More about this image found in Influence of cardiomyocyte-specific deletion of Trbp on cardiac morphology ...
Images
in Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
> Clinical Science
Published: 11 March 2025
Figure 2: Trbp deficiency disrupts fast- and slow-twitch myofiber gene regulation and activates a fibrotic gene profile in the mature heart. qRT-PCR analysis of ( A) fast-twitch and ( B) slow-twitch myofiber gene expression in TrbpcKO hearts with or without TAC (For Myl9, Tpm2, Myl3 and Tnnc1: ... More about this image found in Trbp deficiency disrupts fast- and slow-twitch myofiber gene regulation and...
Images
in Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
> Clinical Science
Published: 11 March 2025
Figure 3: Activation of the TGF-β pathway is intensified in Trbp-cKO hearts prior to and after TAC-induced cardiac stress. (A ) Representative images of cardiac sections from Trbp-cKO and Ctrl mouse hearts two weeks after TAC surgery stained with Fast Green to label fibrotic tissue. Scale bar = ... More about this image found in Activation of the TGF-β pathway is intensified in Trbp-cKO hearts prior to ...
Images
in Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
> Clinical Science
Published: 11 March 2025
Figure 4: Knockdown of Trbp in NRVMs induces the expression of fibrotic markers in co-cultured NRCFs. (A ) qRT-PCR analysis to determine levels of Trbp, Anp and Bnp transcripts in NRVMs with normal or decreased Trbp expression, with and without PE treatment. n = 3. ( B) qRT-PCR analysis to de... More about this image found in Knockdown of Trbp in NRVMs induces the expression of fibrotic markers in co...
Images
in Trbp inhibits cardiac fibrosis through TGF-β pathway-mediated cross-talk between cardiomyocytes and fibroblasts
> Clinical Science
Published: 11 March 2025
Figure 5: Analysis of the role of Trbp on the regulation of Tgfβ2 and Ltbp2 mRNA levels in NRVMs and the effect of altered Trbp and Tgfβ2 levels on fibrotic gene expression in co-cultured NRCFs. (A ) qRT-PCR analysis of Trbp expression in control and Trbp-OE NRVMs. ( B) qRT-PCR analysis o... More about this image found in Analysis of the role of Trbp on the regulation of Tgfβ2 and Ltbp2 mRNA ...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (04): 287–307.
Published: 19 February 2025
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (04): 309–323.
Published: 19 February 2025
..., cardiomyocyte bioenergetics, and Akt/mTOR pathway . Front. Cell Dev. Biol. 9 , 630412 https://doi.org/10.3389/fcell.2021.630412 58 Gu , Z. , Qiu , W. , He , R. , Zhang , Z. and Zhou , X . ( 1999 ) Selection of quantitative criteria for evaluating metastases of a highly...
Includes: Supplementary data
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 1: ACE2 and TMPRSS2 protein levels in endometrial 2D cells (monolayers) and 3D spheroids . HESC and ISK ( n = 6) were cultured as monolayers or as spheroids and treated with decidualizing stimuli medroxyprogesterone acetate (1 µM; MPA) and 8-Bromo-cAMP (0.5 mM) every 48 h for six days. T... More about this image found in ACE2 and TMPRSS2 protein levels in endometrial 2D cells (monolayers) and 3D...
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 2: Infection of 2D Ishikawa cells with SARS-CoV-2 . ( A ) ISK cells were treated with or without cAMP and MPA and infected with SARS-CoV-2-mNG or the clinical isolate B1. After infection, cells were collected for protein extraction and western blotting. Detection of SARS-CoV-2 proteins wa... More about this image found in Infection of 2D Ishikawa cells with SARS-CoV-2 . ( A ) ISK cells were trea...
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 3: Infection of endometrial spheroids with SARS-CoV-2 . HESC and ISK were cultured separately before being added to agarose-coated wells of a 96-well plate for spheroid formation. After two days, the spheroids were treated with 8-Bromo-cAMP and MPA, which was repeated every 48 h. On day s... More about this image found in Infection of endometrial spheroids with SARS-CoV-2 . HESC and ISK were cul...
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 4: Cytokine levels of infected and non-Infected endometrial spheroids . Endometrial spheroids ( n = 5) were cultured for seven days and decidualized for five days prior to infection with SARS-CoV-2 B.1.617.2. Supernatant was collected 24 hpi and 48 hpi and cytokines MCP-1 and IL-8 were ... More about this image found in Cytokine levels of infected and non-Infected endometrial spheroids . Endom...
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 5: DEGs in endometrial spheroids with and without SARS-CoV-2 infection . Endometrial spheroids ( n = 3) were treated with 8-Bromo-cAMP and MPA for five days prior to infection with SARS-CoV-2 B.1.617.2. RNA was extracted 48 hpi and RNA sequencing was performed. ( A ) Dimensional reductio... More about this image found in DEGs in endometrial spheroids with and without SARS-CoV-2 infection . Endo...
Images
in Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy
> Clinical Science
Published: 19 February 2025
Figure 6: Gene set enrichment analysis. ( A ) GSEA against the KEGG database for differentially enriched pathways in genes in endometrial spheroids with and without SARS-CoV-2 infection. Enrichment plots for the two pathways upregulated in the experiments are shown. ( B ) The relative gene positi... More about this image found in Gene set enrichment analysis. ( A ) GSEA against the KEGG database for dif...
Images
in Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury
> Clinical Science
Published: 19 February 2025
Figure 1: Female rats exhibit persistent subclinical renal injury 30 days post-AKI, despite resolution of plasma creatinine levels by three days post-AKI. For this study, 12–13-week-old female SD rats were randomized to sham or 45-minute bilateral ischemia-reperfusion surgery (AKI) and allowed to... More about this image found in Female rats exhibit persistent subclinical renal injury 30 days post-AKI, d...
Images
in Persistent subclinical renal injury in female rats following renal ischemia-reperfusion injury
> Clinical Science
Published: 19 February 2025
Figure 2: AKI induces sustained tubular injury and fibrosis in young female rats. Renal histology was evaluated using H&E ( A ) and renal fibrosis was assessed via Masson’s Trichrome ( B ) in 12–13-week old female SD rats randomized to sham or 45-minute bilateral ischemia-reperfusion surgery ... More about this image found in AKI induces sustained tubular injury and fibrosis in young female rats. Re...
1
