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Keywords: macrophage
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Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (4): 629–649.
Published: 22 February 2021
...-DT activated STAT3 signaling in PDAC cells in an autocrine manner. Furthermore, KLHDC7B-DT also activated STAT3 signaling in macrophages in a paracrine manner, which induced macrophage M2 polarization. KLHDC7B-DT overexpressed PDAC cells-primed macrophages promoted PDAC cell proliferation, migration...
Includes: Supplementary data
Articles
Apabrita Ayan Das, Devasmita Chakravarty, Debmalya Bhunia, Surajit Ghosh, Prakash C. Mandal, Khawer N. Siddiqui, Arun Bandyopadhyay
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (22): 2283–2299.
Published: 21 November 2019
...) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE) −/− mice. Plasma level of sTLT1 was found to be significantly ( P <0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical...
Includes: Supplementary data
Articles
Kengo Sato, Hayami Yoshizawa, Tomomi Seki, Remina Shirai, Tomoyuki Yamashita, Taisuke Okano, Koichiro Shibata, Miyu J. Wakamatsu, Yusaku Mori, Toshisuke Morita, Taka-aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (16): 1779–1796.
Published: 20 August 2019
... −/− mice. In patients with CAD, a small amount of ChemR23, but not chemerin, was expressed within atheromatous plaques in coronary arteries. Chemerin and ChemR23 were expressed at high levels in THP1 monocytes, THP1-derived macrophages, and HUVECs; however, their expression in HASMCs was weak. Chemerin...
Includes: Supplementary data
Articles
Xianglan Liu, Ruoxi Zhang, Jingbo Hou, Jian Wu, Maomao Zhang, Shaohong Fang, Xuedong Wang, Xingtao Huang, Jinwei Tian, Hulun Li, Yong Sun, Bo Yu
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (7): 869–884.
Published: 08 April 2019
... patients with coronary artery disease and recorded serial optical coherence tomography (OCT) images (0 and 3 months) to assess stent endothelialization. The mechanism underlying the regulatory effects of IL-35 on macrophages and human umbilical vein endothelial cells (HUVECs) was also investigated. SESs...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (2): 195–203.
Published: 18 January 2019
... to subsequent stimulation. While it is essential for the host response to pathogens, many diseases are the product of excessive or chronic inflammation. Atherosclerosis is a disease characterized by chronic low-grade inflammation of the arterial wall leading to plaque formation, where macrophages are the most...
Articles
Yuki Sato, Rena Watanabe, Nozomi Uchiyama, Nana Ozawa, Yui Takahashi, Remina Shirai, Kengo Sato, Yusaku Mori, Takaaki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (23): 2493–2507.
Published: 05 December 2018
... in HECs and human THP-1 monocyte-derived macrophages, macrophage foam cell formation, migration and proliferation of human aortic smooth muscle cells (HASMCs) and extracellular matrix (ECM) production by HASMCs, and atherogenesis in apolipoprotein E-deficient (ApoE −/− ) mice. Vasostatin-1 was expressed...
Includes: Supplementary data
Articles
Kumiko Saitou, Masakuni Tokunaga, Daisuke Yoshino, Naoyoshi Sakitani, Takahiro Maekawa, Youngjae Ryu, Motoshi Nagao, Hideki Nakamoto, Taku Saito, Noriaki Kawanishi, Katsuhiko Suzuki, Toru Ogata, Michiru Makuuchi, Atsushi Takashima, Keisuke Sawada, Shunsuke Kawamura, Koichi Nakazato, Karina Kouzaki, Ichiro Harada, Yoshinori Ichihara, Yasuhiro Sawada
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (19): 2147–2161.
Published: 12 October 2018
... interventions modulate immobilization-induced pro-inflammatory responses of macrophages in situ and alleviate muscle atrophy. Local cyclical compression (LCC) on mouse calves, which generates intramuscular pressure waves with amplitude of 50 mmHg, partially restores the myofiber thickness and contracting forces...
Includes: Supplementary data
Articles
Chang Liu, Congcong Zhang, Lixin Jia, Boya Chen, Luxin Liu, Jie Sun, Wenmei Zhang, Bin You, Yulin Li, Ping Li, Jie Du
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (6): 655–668.
Published: 26 March 2018
... mice, showing that MMP12 were significantly down-regulated in IL-3 deficient aortas. Mechanistically, we found recombinant IL-3 could increase MMP12 production and activity from macrophages in vitro . Silencing of IL-3 receptor β, which was mainly expressed in macrophages but not SMCs, diminished...
Includes: Supplementary data
Articles
Zhou Jiang, Juan-Juan Qin, Yaxing Zhang, Wen-Lin Cheng, Yan-Xiao Ji, Fu-Han Gong, Xue-Yong Zhu, Yan Zhang, Zhi-Gang She, Zan Huang, Hongliang Li
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (17): 2275–2288.
Published: 10 August 2017
... in atherogenesis and plaque instability were evaluated in LILRB4 -/- ApoE -/- and ApoE -/- mice fed a high-fat diet (HFD). We found that LILRB4 was located primarily in macrophages, and its expression was up-regulated in atherosclerotic lesions from human coronary arteries and mouse aortic roots. LILRB4 deficiency...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (7): 609–620.
Published: 17 March 2017
... macrophages into the abdominal aorta was increased in HIF-1KO mice. Expression of tissue inhibitors of metalloproteinases (TIMPs) was suppressed in the aorta and peritoneal macrophages (PMs) from HIF-1KO mice compared with control mice. HIF-1α in myeloid lineage cells may have a protective role against AAA...
Includes: Supplementary data
Articles
Sandeep Dhall, João P. Silva, Yan Liu, Michael Hrynyk, Monika Garcia, Alex Chan, Julia Lyubovitsky, Ronald J. Neufeld, Manuela Martins-Green
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (12): 1115–1129.
Published: 22 October 2015
...-treated wounds, the pattern of neutrophil inflammatory response suggests faster clearing of the burned dead tissue. We also observe faster resolution of the pro-inflammatory macrophages. We also found that insulin stimulates collagen deposition and maturation with the fibres organized more like a basket...
Articles
Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J. Jenkins, Gary P. Anderson, Ross Vlahos
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 785–796.
Published: 05 August 2015
... that regulates lung immunity and inflammation. The aim of the present study was to investigate how IL-17A regulates CS-induced lung inflammation in vivo . IL-17A knockout (KO) mice and neutralization of IL-17A in wild-type (WT) mice reduced macrophage and neutrophil recruitment and chemokine (C-C motif) ligand 2...
Articles
Stephanie Zwicker, Gisele L. Martinez, Madeleen Bosma, Marco Gerling, Reuben Clark, Mirjam Majster, Jan Söderman, Sven Almer, Elisabeth A. Boström
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (3): 281–290.
Published: 15 May 2015
... conditions of the intestine. Macrophages play a central role in IBD pathogenesis and are regulated by major differentiation factors such as CSF-1 (colony-stimulating factor 1) in homoeostasis and inflammation. IL (interleukin)-34 has recently been discovered as a second ligand for CSF-1R (CSF-1 receptor...
Includes: Supplementary data
Articles
Mariëtte R. Boon, Leontine E. H. Bakker, Mariëlle C. Haks, Edwin Quinten, Gert Schaart, Lianne Van Beek, Yanan Wang, Linda Van Schinkel, Vanessa Van Harmelen, A. Edo Meinders, Tom H. M. Ottenhoff, Ko Willems Van Dijk, Bruno Guigas, Ingrid M. Jazet, Patrick C. N. Rensen
Journal:
Clinical Science
Clin Sci (Lond) (2015) 128 (2): 143–151.
Published: 19 September 2014
...Mariëtte R. Boon; Leontine E. H. Bakker; Mariëlle C. Haks; Edwin Quinten; Gert Schaart; Lianne Van Beek; Yanan Wang; Linda Van Schinkel; Vanessa Van Harmelen; A. Edo Meinders; Tom H. M. Ottenhoff; Ko Willems Van Dijk; Bruno Guigas; Ingrid M. Jazet; Patrick C. N. Rensen Macrophage markers...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (11): 805–818.
Published: 21 February 2014
.... Specifically, RvE1 promoted a decline in the number of inflammatory cells, concentration of cytokines in lavage fluid and expression of mRNA for cytokines by macrophages, confirming its pro-resolution activity. In vitro , RvE1 had no apparent effect on lymphocytes, but suppressed significantly cytokine...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (5): 221–235.
Published: 07 May 2013
... in atherosclerosis. Monocytes, which comprise part of the innate immune system, can be recruited to inflamed endothelium and this recruitment has been shown to be proportional to the extent of atherosclerotic disease. Monocytes undergo migration into the vasculature, they differentiate into macrophage phenotypes...
Articles
Jun Lv, Xiao Ru Huang, Jörg Klug, Suada Fröhlich, Philipp Lacher, Anping Xu, Andreas Meinhardt, Hui Yao Lan
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (10): 627–637.
Published: 04 February 2013
...Jun Lv; Xiao Ru Huang; Jörg Klug; Suada Fröhlich; Philipp Lacher; Anping Xu; Andreas Meinhardt; Hui Yao Lan RPS19 (ribosomal protein S19), a component of the 40S small ribosomal subunit, has recently been identified to bind the pro-inflammatory cytokine macrophage MIF (migration inhibitory factor...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (5): 187–202.
Published: 25 May 2010
... inhabiting and residing in macrophages, eventually forming a granuloma. From this point on the mycobacteria are continuously exposed to both oxidative and nitrosative stress generated by the activated macrophages that they inhabit [ 34 ]. Macrophages produce ROIs (reactive oxygen intermediates) and RNIs...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 641–655.
Published: 09 March 2010
..., their differentiation into macrophages and the subsequent transformation of macrophages into cholesterol-laden foam cells. Models of hypercholesterolaemia such as the ApoE (apolipoprotein E) −/− mouse and the application of transgenic technologies have allowed us to undertake a thorough dissection of the cellular...
Includes: Multimedia, Supplementary data
Articles
Alan Daugherty, Debra L. Rateri, Israel F. Charo, A. Phillip Owens, III, Deborah A. Howatt, Lisa A. Cassis
Journal:
Clinical Science
Clin Sci (Lond) (2010) 118 (11): 681–689.
Published: 09 March 2010
... in a circumscribed area of the anterior region of ascending aortas in which elastin breaks were focal and almost transmural. All regions of the ascending aorta of AngII-infused mice had diffuse medial macrophage accumulation. Deficiency of CCR2 greatly attenuated the AngII-induced lumen dilatation in the ascending...
Articles
Jingti Deng, Christian H. James, Lisa Patel, Alberto Smith, Kevin G. Burnand, Hassan Rahmoune, Jonathan R. Lamb, Bill Davis
Journal:
Clinical Science
Clin Sci (Lond) (2009) 116 (3): 241–248.
Published: 08 January 2009
...-derived macrophages showed that Trb2 expression was up-regulated by treatment with oxidized LDL (low-density lipoprotein), and that expression of recombinant Trb2 specifically reduced macrophage levels of IL-10 (interleukin-10) mRNA. Our results thus identify Trb2 as a highly regulated gene in vulnerable...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2007) 112 (1): 1–25.
Published: 01 December 2006
...Jan P. Konsman; Benjamin Drukarch; Anne-Marie Van Dam In response to tissue injury or infection, the peripheral tissue macrophage induces an inflammatory response through the release of IL-1β (interleukin-1β) and TNFα (tumour necrosis factor α). These cytokines stimulate macrophages and endothelial...
Articles
Thais Martins de Lima, Maria Fernanda Cury-Boaventura, Gisele Giannocco, Maria Tereza Nunes, Rui Curi
Journal:
Clinical Science
Clin Sci (Lond) (2006) 111 (5): 307–317.
Published: 13 October 2006
...Thais Martins de Lima; Maria Fernanda Cury-Boaventura; Gisele Giannocco; Maria Tereza Nunes; Rui Curi In the present study, the cytotoxicity of palmitic, stearic, oleic, linoleic, arachidonic, docosahexaenoic and eicosapentaenoic acids on a macrophage cell line (J774) was investigated...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (3): 273–278.
Published: 01 September 2003
... the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. Using an in vitro flow cytometry-based phagocytosis assay, we investigated the role of fetuin in apoptotic cell clearance. Bovine fetuin and human α 2 -HS glycoprotein significantly augmented the phagocytosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 105 (3): 267–268.
Published: 01 September 2003
...Janet M. LORD This comment describes the study by Jersmann and co-workers in this issue of Clinical Science reporting the results of a study of the role of the serum glycoprotein fetuin in the uptake of apoptotic cells by macrophages. They show that fetuin is able to stimulate the macropinocytosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2003) 104 (1): 27–38.
Published: 18 December 2002
...Jeremy S. DUFFIELD Recent investigations have highlighted new roles for the macrophage (M ϕ ) in the biology of inflammation. Selective depletion of M ϕ s from inflamed sites has confirmed their predominant role in immune-mediated damage. The components of this injury have been dissected. M ϕ s...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2002) 103 (5): 441–449.
Published: 03 October 2002
... of neutrophil granulocytes is an important determinant of the resolution of inflammation, providing a mechanism for down-regulation of function and triggering clearance by macrophages without inducing a pro-inflammatory response. However, if the rate of cell death by apoptosis is such that the macrophage...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (2): 111–119.
Published: 18 June 2001
...Caryn L. ELSEGOOD; Sebely PAL; Paul D. ROACH; John C. L. MAMO The binding and uptake of chylomicron remnants by human macrophages was studied in order to resolve paradoxical observations that have described the putative mechanisms by which postprandial lipoproteins induce foam cell formation...
Articles
Thomas A. HEMING, Divina M. TUAZON, Sanat K. DAVÉ, Ashok K. CHOPRA, Johnny W. PETERSON, Akhil BIDANI
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (3): 259–266.
Published: 24 January 2001
...Thomas A. HEMING; Divina M. TUAZON; Sanat K. DAVÉ; Ashok K. CHOPRA; Johnny W. PETERSON; Akhil BIDANI The present studies determined the effects of extracellular pH (pH o ) on the production of tumour necrosis factor-α (TNF-α) in the macrophage-like cell lines RAW 246.7 and J774 A.1. The cells were...
Articles
Masaharu NAKAYAMA, Kazuhiro TAKAHASHI, Osamu MURAKAMI, Hiroshi MURAKAMI, Hironobu SASANO, Kunio SHIRATO, Shigeki SHIBAHARA
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (2): 247–251.
Published: 15 July 1999
...Masaharu NAKAYAMA; Kazuhiro TAKAHASHI; Osamu MURAKAMI; Hiroshi MURAKAMI; Hironobu SASANO; Kunio SHIRATO; Shigeki SHIBAHARA Macrophages secrete a variety of growth factors, cytokines and vasoactive peptides, which are related to the progression of atherosclerosis. Adrenomedullin (ADM) is a potent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1994) 86 (5): 627–632.
Published: 01 May 1994
...-hydroxylase activity in rat kidney homogenates was not different between control and cyclosporin A-treated rats. Renal 25-hydroxyvitamin D-1α-hydroxylase activity was not detectable in these homogenates. Extra-renal production of 1,25-dihydroxyvitamin D by activated macrophages isolated from the synovial...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1988) 75 (6): 561–567.
Published: 01 December 1988
... dipeptide, immune complexes, ultra- violet irradiation and some other cytokines [3]. In vivo, the most important cell, is probably the macrophage which releases IL- 1/3 locally at sites of inflammation. IL- 1 induces proliferation of endothelial cells, fibro- blasts and synovial cells, sometimes...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1985) 68 (5): 561–565.
Published: 01 May 1985
...H. A. Simmonds; A. Goday; G. S. Morris 1. The importance of intact adenosine deaminase (ADA) activity in the generation of superoxide anion by xanthine oxidase has been disputed in studies using human neutrophils or mouse macrophages. The latter demonstrated a positive correlation between ADA...
