Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
Filter
- Title
- Author
- Author Affiliations
- Full Text
- Abstract
- Keyword
- DOI
- ISSN
- EISSN
- Issue
- Volume
- References
NARROW
Format
Subjects
Article Type
Date
Availability
1-36 of 36
Keywords: macrophages
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2025) 139 (02): 151–169.
Published: 13 January 2025
..., govern their dynamics by adding, removing, and recognizing lactyl groups on proteins. Macrophages, as cells of the immune system, maintain homeostasis, responding dynamically to diverse internal and external stimuli. Emerging researches unveil that lactylation, through inducing macrophage activation...
Articles
Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Hannah L. Smith, Robert A. Montalvo, II, Alyssa Cardenas, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (14): 921–940.
Published: 16 July 2024
...Shobana Navaneethabalakrishnan; Bethany L. Goodlett; Hannah L. Smith; Robert A. Montalvo, II; Alyssa Cardenas; Brett M. Mitchell Salt-sensitive hypertension (SSHTN) is associated with M1 macrophage polarization and inflammatory responses, leading to inflammation-associated lymphangiogenesis...
Includes: Supplementary data
Articles
Shobana Navaneethabalakrishnan, Bethany L. Goodlett, Hannah L. Smith, Alyssa Cardenas, Asia Burns, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2024) 138 (14): 901–920.
Published: 16 July 2024
... BY) . hypertension lymphatics macrophages ovaries renal physiology testes American Heart Association (AHA) 100000968 916912 Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) 100017618 DK120493 Hypertension (HTN) plays a significant role in causing end organ damage...
Includes: Supplementary data
Articles
Ama D. Okyere, Tapas K. Nayak, Viren Patwa, David Teplitsky, Erin McEachern, Rhonda L. Carter, Heli Xu, Erhe Gao, Yan Zhou, Douglas G. Tilley
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (19): 1513–1531.
Published: 28 September 2023
...Ama D. Okyere; Tapas K. Nayak; Viren Patwa; David Teplitsky; Erin McEachern; Rhonda L. Carter; Heli Xu; Erhe Gao; Yan Zhou; Douglas G. Tilley Myeloid cells, including macrophages, play important roles as first responders to cardiac injury and stress. Epidermal growth factor receptor (EGFR) has been...
Includes: Supplementary data
Articles
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (15): 1067–1093.
Published: 02 August 2023
...Zuzana Strizova; Iva Benesova; Robin Bartolini; Rene Novysedlak; Eva Cecrdlova; Lily Koumbas Foley; Ilja Striz Macrophages represent heterogeneous cell population with important roles in defence mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (5): 355–366.
Published: 09 March 2023
... of macrophages in removal of TTR deposits in ATTRv patients. The mechanisms underlying this impairment of inflammatory responses in ATTRv patients are poorly understood. Here, we show a significant down-regulation in the expression of several chemokines by bone marrow-derived macrophages (BMDM) generated from...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (15): 1111–1115.
Published: 01 August 2022
... to be achieved through the modulation of the macrophage populations present in the liver. Here, we discuss the main findings of this work and raise some outstanding questions regarding the possible mechanisms involved and the functions of distinct macrophage populations in NASH. References 1. Eslam M...
Articles
Shobana Navaneethabalakrishnan, Brooke K. Wilcox, Bethany L. Goodlett, Malea M. Murphy, Brett M. Mitchell
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (11): 879–894.
Published: 06 June 2022
... (M2) macrophage ratio, increased inflammation, and inflammation-associated lymphangiogenesis have been observed in animals with HTN. However, the impact of HTN on gonadal macrophages, inflammation, and lymphatics remains obscure. We hypothesized that salt-sensitive HTN (SSHTN) and HTN alters gonadal...
Includes: Supplementary data
Articles
Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis
Laila Lavanya Gadipudi, Naresh Naik Ramavath, Alessia Provera, Chris Reutelingsperger, Emanuele Albano, Mauro Perretti, Salvatore Sutti
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (9): 643–656.
Published: 04 May 2022
... attenuated the hepatic expression of α1-procollagen and TGF-β1 and reduced collagen deposition, as evaluated by collagen Sirius Red staining. Flow cytometry and immunohistochemistry showed that hrAnxA1 did not affect the liver recruitment of macrophages, but strongly interfered with the formation of crown...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (6): 435–454.
Published: 29 March 2022
... characterised in innate and adaptive immune cells, and discuss how macrophages’ and T cells’ metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs). atherosclerosis cardiovascular disease...
Articles
Sudhir Kotnala, Yerin Kim, Charu Rajput, Hymavathi Reddyvari, Sudhir Bolla, Nathaniel T. Marchetti, Beata Kosmider, Karim Bahmed, Umadevi S. Sajjan
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (17): 2067–2083.
Published: 01 September 2021
... with inflammation in various organs, including LPS-induced acute lung inflammation. Since non-typeable Haemophilus influenzae (NTHi) causes acute exacerbations in COPD patients, we examined the contribution of DPP4 in NTHi-induced lung inflammation in COPD. Pulmonary macrophages isolated from COPD patients showed...
Articles
Ellesandra C. Noye, Siroon Bekkering, Albert P. Limawan, Maria U. Nguyen, Lisa K. Widiasmoko, Hui Lu, Salvatore Pepe, Michael M. Cheung, Trevelyan R. Menheniott, Megan J. Wallace, Timothy J. Moss, David P. Burgner, Kirsty R. Short
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (15): 1859–1871.
Published: 04 August 2021
... inflammation has additive and deleterious effects on atherosclerosis in ApoE −/− mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis. Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated...
Includes: Supplementary data
Articles
Antigona Ulndreaj, Angela Li, Yonghong Chen, Rickvinder Besla, Shaun Pacheco, Marwan G. Althagafi, Myron I. Cybulsky, Thomas Lindsay, Clinton S. Robbins, John S. Byrne
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (10): 1295–1309.
Published: 28 May 2021
...Antigona Ulndreaj; Angela Li; Yonghong Chen; Rickvinder Besla; Shaun Pacheco; Marwan G. Althagafi; Myron I. Cybulsky; Thomas Lindsay; Clinton S. Robbins; John S. Byrne Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA...
Includes: Supplementary data
Articles
Priscila Andrade Ranéia e Silva, Dhêmerson Souza de Lima, João Paulo Mesquita Luiz, Niels Olsen Saraiva Câmara, José Carlos Farias Alves-Filho, Alessandra Pontillo, Karina Ramalho Bortoluci, Eliana L. Faquim-Mauro
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
... and/or inducing pyroptotic cell death in response to tissue damage. We, therefore, aimed to address activation of NLRP3 inflammasome by BthTX-I-associated injury and the mechanism involved in this process. Intramuscular injection of BthTX-I results in infiltration of neutrophils and macrophages in gastrocnemius...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1631–1635.
Published: 01 July 2020
...Stephan F. van Eeden; Kentaro Akata Lung macrophages (LMs) are key immune effector cells that protect the lung from inhaled particulate matter, noxious gases and pathogens. In Chronic Obstructive Pulmonary Disease (COPD), there is an abundance of macrophages in airspaces and lung tissues suggesting...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
... wall, monocyte differentiation to macrophages and uptake of oxidized low density lipoprotein. Macrophage activation and inflammatory cytokine production are major factors which drive ongoing inflammation and plaque development. Identification of novel pathways driving this on-going inflammatory process...
Articles
Yu Sun, Juan Guan, Yunfeng Hou, Fei Xue, Wei Huang, Wencheng Zhang, Yun Zhang, Cheng Zhang, Jianmin Yang
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
... in macrophages. Enhanced expression of JAML in cultured macrophages was observed following exposure of the cells to oxLDL. The functional role of JAML in atherosclerosis and macrophages function was assessed by interference of JAML with shRNA in vivo and siRNA in vitro . Silencing of JAML in mice significantly...
Includes: Supplementary data
Articles
Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis
Joao A. Gimenes, Jr, Vikram Srivastava, Hymavathi ReddyVari, Sudhir Kotnala, Rahul Mishra, Mohamed Farazuddin, Wuyan Li, Umadevi S. Sajjan
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (8): 983–996.
Published: 29 April 2019
... (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b + /CD11c + ), and CD8 + T cells, and progression of emphysema. In the present study, we examined the mechanisms underlying...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1253–1256.
Published: 21 June 2018
... in Clinical Science (2018) 132 (6), 655–668), Liu et al . explore the mechanism through which aortic vascular smooth cells and macrophages participate in TAAD using a mouse model. The authors propose that interleukin-3 (IL-3) released from aortic vascular smooth cells is central to the disease process. IL-3...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
... and ANCHOR studies . Am. J. Cardiovasc. Drugs 13 , 37 – 46 10.1007/s40256-012-0002-3 23325450 atherosclerosis atherogenesis inflammation lipids macrophages statins Numerous data support the key role of the inflammatory mechanisms to atheroma formation [ 1–4 ]. Leukocyte...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (5): 609–613.
Published: 15 March 2018
... following DILI. androgen receptor drug-induced liver injury immunity monocytes macrophages Drug-induced liver injury (DILI) is a major hurdle in drug discovering and manufacturing, since it represents one of the most frequent reasons of failures in terms of marketing innovative therapeutic...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (16): 2161–2182.
Published: 31 July 2017
...Rocio Rojo; Clare Pridans; David Langlais; David A. Hume The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF) receptor (CSF1R). CSF1R is expressed by embryonic macrophages and induced early...
Articles
Rui Curi, Renata de Siqueira Mendes, Luiz Aurélio de Campos Crispin, Giuseppe Danilo Norata, Sandra Coccuzzo Sampaio, Philip Newsholme
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
...Rui Curi; Renata de Siqueira Mendes; Luiz Aurélio de Campos Crispin; Giuseppe Danilo Norata; Sandra Coccuzzo Sampaio; Philip Newsholme In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (11): 1107–1121.
Published: 17 May 2017
... transport and corrects mislocalization of the most common CF mutation, F508del-CFTR. It also reduces lung pro-inflammatory responses in mice and in patients with CF. To test the hypothesis that macrophages are target effector cells of the immunomo-dulatory effect of vardenafil, we isolated lung macrophages...
Includes: Supplementary data
Articles
Elisa Vivoli, Andrea Cappon, Stefano Milani, Benedetta Piombanti, Angela Provenzano, Erica Novo, Alessio Masi, Nadia Navari, Roberto Narducci, Guido Mannaioni, Gloriano Moneti, Claudia P. Oliveira, Maurizio Parola, Fabio Marra
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (20): 1793–1806.
Published: 09 September 2016
... of action are poorly understood. In the present study, we tested BRB in steatohepatitis induced by a methionine- and choline-deficient (MCD) diet, in acute acetaminophen intoxication and in cultured murine macrophages. BRB markedly improved parameters of liver injury and necroinflammation induced by the MCD...
Includes: Supplementary data
Articles
Xia Kang, Along Hou, Rui Wang, Da Liu, Wei Xiang, Qingyun Xie, Bo Zhang, Lixia Gan, Wei Zheng, Hongming Miao
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
Includes: Supplementary data
Articles
Luciano Ribeiro Filgueiras, Marianna Mainardi Koga, Paula G. Quaresma, Edson Kiyotaka Ishizuka, Marlise B.A. Montes, Patricia O. Prada, Mario J. Saad, Sonia Jancar, Francisco J. Rios
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (8): 601–612.
Published: 08 March 2016
...Luciano Ribeiro Filgueiras; Marianna Mainardi Koga; Paula G. Quaresma; Edson Kiyotaka Ishizuka; Marlise B.A. Montes; Patricia O. Prada; Mario J. Saad; Sonia Jancar; Francisco J. Rios Metabolic dysfunction is associated with adipose tissue inflammation and macrophage infiltration. PAFR (platelet...
Includes: Supplementary data
Articles
Salvatore Sutti, Irene Locatelli, Stefania Bruzzì, Aastha Jindal, Marco Vacchiano, Cristina Bozzola, Emanuele Albano
Journal:
Clinical Science
Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
...Salvatore Sutti; Irene Locatelli; Stefania Bruzzì; Aastha Jindal; Marco Vacchiano; Cristina Bozzola; Emanuele Albano Liver monocytes play a major role in the development of NASH (non-alcoholic steatohepatitis). In inflamed tissues, monocytes can differentiate in both macrophages and dendritic cells...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 101 (4): 403–413.
Published: 14 September 2001
...Mariarosaria NAPOLITANO; Kelly V. BATT; Michael AVELLA; Elena BRAVO; Kathleen M. BOTHAM The effects of native and oxidized chylomicron remnants on the synthesis of cholesteryl ester and triacylglycerol in macrophages, and the way that this is influenced by exposure of the cells to oestrogen...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2000) 98 (2): 183–192.
Published: 11 January 2000
...Kenneth C.-W. YU; John C. L. MAMO The effects of chylomicron remnants on cytoplasmic lipid loading and cell viability were assessed in cultures of human monocyte-derived macrophages and rabbit arterial smooth muscle cells. At a cholesterol concentration of 150 μ g/ml, chylomicron remnants induced...
Articles
Lindsay E. ROBINSON, Françoise I. BUSSIÈRE, Jacques LE BOUCHER, Marie-Chantal FARGES, Luc A. CYNOBER, Catherine J. FIELD, Vickie E. BARACOS
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (6): 657–669.
Published: 29 October 1999
... for 14 days after implantation of the Morris hepatoma 7777 ( n ⩾ 7 per diet). The control diet was made isonitrogenous and isoenergetic by addition of a mixture of non-essential amino acids. After 14 days, peritoneal macrophages and splenocytes were isolated to determine cell phenotypes, macrophage...
Articles
Christophe MOINARD, Béatrice CHAUVEAU, Stéphane WALRAND, Catherine FELGINES, Jacques CHASSAGNE, Florence CALDEFIE, Luc A. CYNOBER, Marie-Paule VASSON
Journal:
Clinical Science
Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
...), a precursor of both glutamine and arginine] on phagocyte functions [i.e. H 2 O 2 production by leucocytes and secretion of tumour necrosis factor α (TNFα) by stimulated macrophages] of stressed rats were studied. The relationship between the immunological effects of these amino acids and their plasma...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 96 (1): 89–97.
Published: 01 January 1999
...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (4): 397–407.
Published: 01 October 1998
...Colin MURPHY; Philip NEWSHOLME 1. The intermediates of biochemical cycles are commonly utilized for biosynthetic processes; thus at least one intermediate must be replenished de novo to provide constant flux through the cycle. The utilization of l -arginine for NO synthesis in macrophages may thus...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1997) 92 (3): 277–284.
Published: 01 March 1997
... and S -nitroso- N -acetyl-penicillamine which corresponded with an increased concentration of nitrite accumulation in the culture medium. 5. High concentrations of nitrites were measured in the medium of granulosa/lutein cells co-cultured with peritoneal macrophages and progesterone synthesis...
Articles
H. Terence Cook, Alison J. Bune, Albertine S. Jansen, G. Michael Taylor, Rashpal K. Loi, Victoria Cattell
Journal:
Clinical Science
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... to localize inducible NO synthase in rats given lipopolysaccharide or Corynebacterium parvum and lipopolysaccharide. Immunohistochemistry was carried out with an antibody raised against a synthetic peptide of mouse macrophage NO synthase. In situ hybridization was performed with 35 S-labelled oligonucleotide...