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Keywords: macrophages
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Articles
Clin Sci (Lond) (2021) CS20210496.
Published: 23 July 2021
... has additive and deleterious effects on atherosclerosis in ApoE -/- mice. Here, we aimed to investigate whether innate immune training is a contributory inflammatory mechanism in this murine model of atherosclerosis.Methods: Bone marrow-derived macrophages and peritoneal macrophages were isolated from...
Articles
Clin Sci (Lond) (2021) 135 (10): 1295–1309.
Published: 28 May 2021
...Antigona Ulndreaj; Angela Li; Yonghong Chen; Rickvinder Besla; Shaun Pacheco; Marwan G. Althagafi; Myron I. Cybulsky; Thomas Lindsay; Clinton S. Robbins; John S. Byrne Objective: Aortic macrophage accumulation is characteristic of the pathogenesis of abdominal aortic aneurysm (AAA) but the...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2021) 135 (5): 687–701.
Published: 09 March 2021
.../or inducing pyroptotic cell death in response to tissue damage. We, therefore, aimed to address activation of NLRP3 inflammasome by BthTX-I-associated injury and the mechanism involved in this process. Intramuscular injection of BthTX-I results in infiltration of neutrophils and macrophages in...
Articles
Clin Sci (Lond) (2020) 134 (13): 1631–1635.
Published: 01 July 2020
...Stephan F. van Eeden; Kentaro Akata Lung macrophages (LMs) are key immune effector cells that protect the lung from inhaled particulate matter, noxious gases and pathogens. In Chronic Obstructive Pulmonary Disease (COPD), there is an abundance of macrophages in airspaces and lung tissues suggesting...
Articles
Clin Sci (Lond) (2019) 133 (14): 1581–1585.
Published: 22 July 2019
... wall, monocyte differentiation to macrophages and uptake of oxidized low density lipoprotein. Macrophage activation and inflammatory cytokine production are major factors which drive ongoing inflammation and plaque development. Identification of novel pathways driving this on-going inflammatory process...
Articles
Clin Sci (Lond) (2019) 133 (11): 1215–1228.
Published: 03 June 2019
... macrophages. Enhanced expression of JAML in cultured macrophages was observed following exposure of the cells to oxLDL. The functional role of JAML in atherosclerosis and macrophages function was assessed by interference of JAML with shRNA in vivo and siRNA in vitro . Silencing of JAML in mice significantly...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (8): 983–996.
Published: 29 April 2019
... (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b + /CD11c + ), and CD8 + T cells, and progression of emphysema. In the present study, we examined the mechanisms underlying...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (12): 1253–1256.
Published: 21 June 2018
... in Clinical Science (2018) 132 (6), 655–668), Liu et al . explore the mechanism through which aortic vascular smooth cells and macrophages participate in TAAD using a mouse model. The authors propose that interleukin-3 (IL-3) released from aortic vascular smooth cells is central to the disease...
Articles
Clin Sci (Lond) (2018) 132 (12): 1243–1252.
Published: 21 June 2018
... 08 05 2018 10 05 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis atherogenesis inflammation lipids macrophages statins Numerous data support the key role of the inflammatory mechanisms to atheroma...
Articles
Clin Sci (Lond) (2018) 132 (5): 609–613.
Published: 15 March 2018
... regenerative responses following DILI. Therefore, considering the increased CD68 + macrophage numbers in the liver of male mice, they analyzed whether differences in immune system activation might account for the sex-dependent discrepancies seen in the recovery process. In support of this hypothesis, the...
Articles
Clin Sci (Lond) (2017) 131 (16): 2161–2182.
Published: 31 July 2017
...Rocio Rojo; Clare Pridans; David Langlais; David A. Hume The proliferation, differentiation, and survival of cells of the macrophage lineage depends upon signals from the macrophage colony-stimulating factor (CSF) receptor (CSF1R). CSF1R is expressed by embryonic macrophages and induced early in...
Articles
Clin Sci (Lond) (2017) 131 (12): 1329–1342.
Published: 07 June 2017
...Rui Curi; Renata de Siqueira Mendes; Luiz Aurélio de Campos Crispin; Giuseppe Danilo Norata; Sandra Coccuzzo Sampaio; Philip Newsholme In 1986 and 1987, Philip Newsholme et al. reported macrophages utilize glutamine, as well as glucose, at high rates. These authors measured key enzyme activities...
Articles
Clin Sci (Lond) (2017) 131 (11): 1107–1121.
Published: 17 May 2017
... transport and corrects mislocalization of the most common CF mutation, F508del-CFTR. It also reduces lung pro-inflammatory responses in mice and in patients with CF. To test the hypothesis that macrophages are target effector cells of the immunomo-dulatory effect of vardenafil, we isolated lung macrophages...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (20): 1793–1806.
Published: 09 September 2016
... of action are poorly understood. In the present study, we tested BRB in steatohepatitis induced by a methionine- and choline-deficient (MCD) diet, in acute acetaminophen intoxication and in cultured murine macrophages. BRB markedly improved parameters of liver injury and necroinflammation induced by...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (14): 1257–1268.
Published: 13 June 2016
... demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet (HFD)-induced insulin resistance and chronic inflammation, characterized by the elevation of proinflammatory cytokines in the blood, liver and white adipose tissue, as well as a proinflammatory profile of immune cells in visceral...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (8): 601–612.
Published: 08 March 2016
...Luciano Ribeiro Filgueiras; Marianna Mainardi Koga; Paula G. Quaresma; Edson Kiyotaka Ishizuka; Marlise B.A. Montes; Patricia O. Prada; Mario J. Saad; Sonia Jancar; Francisco J. Rios Metabolic dysfunction is associated with adipose tissue inflammation and macrophage infiltration. PAFR (platelet...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (9): 797–808.
Published: 07 August 2015
...Salvatore Sutti; Irene Locatelli; Stefania Bruzzì; Aastha Jindal; Marco Vacchiano; Cristina Bozzola; Emanuele Albano Liver monocytes play a major role in the development of NASH (non-alcoholic steatohepatitis). In inflamed tissues, monocytes can differentiate in both macrophages and dendritic cells...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2001) 101 (4): 403–413.
Published: 14 September 2001
...Mariarosaria NAPOLITANO; Kelly V. BATT; Michael AVELLA; Elena BRAVO; Kathleen M. BOTHAM The effects of native and oxidized chylomicron remnants on the synthesis of cholesteryl ester and triacylglycerol in macrophages, and the way that this is influenced by exposure of the cells to oestrogen, was...
Articles
Clin Sci (Lond) (2000) 98 (2): 183–192.
Published: 11 January 2000
...Kenneth C.-W. YU; John C. L. MAMO The effects of chylomicron remnants on cytoplasmic lipid loading and cell viability were assessed in cultures of human monocyte-derived macrophages and rabbit arterial smooth muscle cells. At a cholesterol concentration of 150 μ g/ml, chylomicron remnants induced...
Articles
Clin Sci (Lond) (1999) 97 (6): 657–669.
Published: 29 October 1999
... for 14 days after implantation of the Morris hepatoma 7777 ( n ⩾ 7 per diet). The control diet was made isonitrogenous and isoenergetic by addition of a mixture of non-essential amino acids. After 14 days, peritoneal macrophages and splenocytes were isolated to determine cell phenotypes, macrophage...
Articles
Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
... precursor of both glutamine and arginine] on phagocyte functions [i.e. H 2 O 2 production by leucocytes and secretion of tumour necrosis factor α (TNFα) by stimulated macrophages] of stressed rats were studied. The relationship between the immunological effects of these amino acids and their plasma and...
Articles
Clin Sci (Lond) (1998) 96 (1): 89–97.
Published: 01 January 1999
...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...
Articles
Clin Sci (Lond) (1998) 95 (4): 397–407.
Published: 01 October 1998
...Colin MURPHY; Philip NEWSHOLME 1. The intermediates of biochemical cycles are commonly utilized for biosynthetic processes; thus at least one intermediate must be replenished de novo to provide constant flux through the cycle. The utilization of l -arginine for NO synthesis in macrophages may thus...
Articles
Clin Sci (Lond) (1997) 92 (3): 277–284.
Published: 01 March 1997
... nitroprusside and S -nitroso- N -acetyl-penicillamine which corresponded with an increased concentration of nitrite accumulation in the culture medium. 5. High concentrations of nitrites were measured in the medium of granulosa/lutein cells co-cultured with peritoneal macrophages and progesterone synthesis was...
Articles
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... to localize inducible NO synthase in rats given lipopolysaccharide or Corynebacterium parvum and lipopolysaccharide. Immunohistochemistry was carried out with an antibody raised against a synthetic peptide of mouse macrophage NO synthase. In situ hybridization was performed with 35 S-labelled...