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Keywords: maladaptive remodelling
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Articles
High serum thrombospondin-1 concentration is associated with slower abdominal aortic aneurysm growth and deficiency of thrombospondin-1 promotes angiotensin II induced aortic aneurysm in mice
Available to PurchaseSmriti Murali Krishna, Sai Wang Seto, Roby Jose, Jiaze Li, Joseph Moxon, Paula Clancy, David J. Crossman, Paul Norman, Theophilus I. Emeto, Jonathan Golledge
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (12): 1261–1281.
Published: 07 June 2017
... reduced aortic expression of low-density lipoprotein (LDL) receptor-related protein 1. Collectively, findings from the present study suggest that TSP-1 deficiency promotes maladaptive remodelling of the ECM leading to accelerated AAA progression. Sera from AAA patients were assayed to measure...
Includes: Supplementary data
