...N. J. Samani; A. K. Ruprai; W. J. Brammar; J. D. Swales 1. We have examined the hypothesis that the raised plasma renin activity in patients with malignant hypertension without an underlying cause is the consequence of expression of a duplicate renin gene. 2. DNA extracted from leucocytes...

... as drinking water. SHR treated with DOC-salt for 4 weeks showed the characteristics of malignant hypertension including marked increases in blood pressure and left ventricular weight with typical histological changes in the kidney. 2. DOC-salt treatment increased plasma vasopressin levels in WKY (from 6.1...

... after aortic ligation. 2. A threefold increase in plasma corticosterone was observed during both the acute and chronic phases of malignant hypertension, whereas in benign hypertension, after a short-lasting twofold increase, corticosterone returned to normal within 9 days. 3. Thymus atrophy, thymocyte...

...T. Gudbrandsson; L. Hansson; H. Herlitz; R. Sivertsson 1. Blood flow resistance was studied in two peripheral vascular beds in 15 patients with previous malignant hypertension and in a matched group of patients with treated ‘benign’ hypertension and in matched control subjects. Studies were made...

...J. Giese 1. The syndrome of malignant hypertension in man and animals has three fundamental components: high blood pressure, activation of the renin—angiotensin system and the rapid development of necrotizing arteriolar disease. 2. The high blood pressure can be associated with different...

... 1976 angiotensin II arterioles deoxycorticosterone endothelial damage malignant hypertension Clinical Science and Molecular Medicine (1976) 51, 31s-32s. The arteriolar lesions of steroid hypertension in rats F. S . GOLDBY K . R. U.F. Institute of Renal Disease, Welsh National Scliool...

... of a vascular bed to high blood pressure results in a rapid damage of the vascular wall, irrespective of the state of the renin—angiotensin system. © 1976 The Biochemical Society and the Medical Research Society 1976 angiotensin renal artery stenosis renin malignant hypertension Clinical Science...

.... © 1976 The Biochemical Society and the Medical Research Society 1976 malignant hypertension renal hypertension renin Clinical Science and Molecular Medicine (1976) 51,69~-71s. Accelerated hypertension in the rat: relation between renin, renal vascular lesions, salt intake and blood...

... extractable from the clamped and the contralateral kidney and malignant nephrosclerosis of the contralateral kidney. These symptoms characterize the malignant phase of renal hypertension in rats. 2. When water was given as drinking fluid, ten of eighteen rats developed signs of malignant hypertension...