...Zhigang He; Yue Li; Sunqiang Ma; Muqing Yang; Yuanyuan Ma; Cheng Ma; Jian Song; Tianyu Yu; Siqi Zhang; Jiyu Li The pathological changes following liver damage, including those caused by ischemia and reperfusion (I/R), are closely related to gastrointestinal dysregulation. Mast cells (MCs...

..., and lung tissue was prepared for histology. The contribution of mast cell mediators was investigated using inhibitors of the main mast cell mediators [histamine (pyrilamine) and CysLTs (cysteinyl-leukotrienes) (montelukast) and prostanoids (indomethacin)]. OVA-sensitized and challenged animals demonstrated...

... responses. Human mast cells are potent effector cells of the innate immune system, and the triacylglycerol (triglyceride) stores of their cytoplasmic LDs have been shown to contain large amounts of arachidonic acid, the main precursor of pro-inflammatory eicosanoids. In the present review, we discuss...

...Elena BARGAGLI; Caterina BIGLIAZZI; Alessandra LEONINI; Nikolaos NIKIFORAKIS; Maria G. PERARI; Paola ROTTOLI In order to characterize BAL (bronchoalveolar lavage) in CEP (chronic eosinophilic pneumonia) and to investigate the possible role of mast cells and tryptase in the pathogenesis...

...M. G. Buckley; C. Walters; W. M. Wong; M. I. D. Cawley; S. Ren; L. B. Schwartz; A. F. Walls 1. Although mast cell hyperplasia is a feature of rheumatoid arthritis and osteoarthritis, the extent and nature of mast cell activation in joint disease have not been clearly established. 2. We have...

... in population studies. 2. No information is available on the functional consequences of any of these variants, and defining this may prove difficult because of the complexity of the atopy phenotype and because FcεRIβ is expressed on a range of cells with different functions, including basophils, mast cells...

... disease compared with infective diarrhoea, but these changes were not sufficient to account for the marked increase in faecal lactoferrín excretion in inflammatory bowel disease. 4. In all mucosal samples, including those from normal mucosa, lactoferrín was also shown to be contained within mast cells. 5...

..., followed by repair processes. This is frequently associated with bronchial hyper-responsiveness. A common feature of tissue repair is an increase in the number of mast cells. Three phenotypically distinct mast cell subsets, with respect to their protease content, have been identified in rat lung...

.... Plasma concentrations of sodium cromoglycate were found to be 209 ± 22 nmol/l at the end of the drug infusion. This is about one-hundredth of lowest dose required to stabilize mast cells in vitro. 6. We conclude that sodium cromoglycate acted by a mechanism which did not involve mast cells. Other...