... • HIF-1α knockout in macrophages rather exaggerated AAA formation, though HIF-1α is reported to induce inflammation via cytokine induction and ECM degradation in AAA tissue. • Expression of TIMPs that directly inhibit matrix metalloproteinases (MMPs) was decreased in HIF-1α deficient macrophages...

...Xiao-feng Chen; Jian-an Wang; Jun Hou; Chun Gui; Li-jiang Tang; Xiao-quan Chen; Xiao-jie Xie; Jian-jun Jiang; Ju-fang Cai; Han-song Chen; Hong-sheng Lu; Han Chen The aim of the present study was to determine whether EMMPRIN (extracellular matrix metalloproteinase inducer) is present and is up...

... myocardium of β 2 -TG compared with NTG mice (1.6-fold) or rats compared with 129sv mice (2-fold) and an accelerated fibrotic healing in the infarcted myocardium. Additionally, a less pronounced increase in MMP-9 (matrix metalloproteinase-9) activity was observed in the infarcted myocardium of rats compared...

...Ping-Yen LIU; Wei-Chuan TSAI; Chih-Chan LIN; Chih-Hsin HSU; Yao-Yi HAUNG; Jyh-Hong CHEN The aim of the present study was to assess the association between invasive PWV (pulse wave velocity), serum levels of MMPs (matrix metalloproteinases) and the echocardiographic severity and calcification score...

.... As demonstrated by ELISA, we found that the secretion of matrix metalloproteinase (MMP)-2 and MMP-9, urokinase-type plasminogen activator and plasminogen activator inhibitor type-1 and -2 was upregulated by ET-1 in a dose-dependent manner in the HEY cell line. In addition, the MMPs in ET-1-treated cells...