.... In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described. Cerebral autosomal dominant...

... in the contractile response. Focal adhesions (FAs) are conceivable candidates that may influence SMC contraction. They are required for actin-based traction employed by cells to sense and respond to environmental cues in a process termed mechanotransduction. Depletion of FA proteins impairs SMC contractility...

... cues to initiate intracellular signaling pathway(s), thereby changing cellular behaviors and functions. However, the precise role of matrix–cell interactions involved in mechanotransduction during vascular homeostasis and disease development remains to be fully determined. In this review, we introduce...

... Society 2020 biophysics mechanotransduction podocytes Ferrimagnetic beads are a method to apply a defined force to cells by applying a magnetic force to move the ferrimagnetic beads in a controlled manner ( Figure 2 ). A study by Eekhoff and colleagues stretched podocytes using...