... of mycophenolate or rapamycin on kidney fibrosis in LN has not been investigated. We investigated the effects of mycophenolate and rapamycin in New Zealand Black and White first generation (NZB/W F1) murine LN and human mesangial cells (HMCs), focusing on mechanisms leading to kidney fibrosis. Treatment of mice...

... 05 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 biomarkers diabetes diabetic kidney disease glomerulus GSK-3β inflammation lncRNA mesangial cells pathogenesis podocytes renal tubular cells therapies Diabetic...

... (STZ)-induced diabetic mice at 18 weeks or in unilateral ureteral obstruction (UUO) mice at 7 days. miR-378 transfection of proximal tubular epithelial cells, NRK52E and mesangial cells was assessed with/without endogenous miR-378 knockdown using the locked nucleic acid (LNA) inhibitor. NRK52E cells...

...Andrey SOROKIN; Marco FOSCHI; Michael J. DUNN The molecular mechanisms of endothelin (ET)-dependent activation of extracellular signal-regulated kinase (ERK)and p38 mitogen-activated protein (MAP) kinase were studied in rat and human renal glomerular mesangial cells. ET-1 induced a rapid...

...R. J. D'Souza; H. M. Phillips; P. W. Jones; R. C. Strange; G. M. Aber 1. This study examined the influence of H 2 O 2 , interleukin-6 and platelet-derived growth factor on the proliferation of rat mesangial cells. Mesangial cells were exposed to either a single pulse or three daily pulses of H 2 O...