...Charles S. Fulco; Steven R. Muza; Dan Ditzler; Eric Lammi; Steven F. Lewis; Allen Cymerman Acetazolamide can be taken at sea level to prevent acute mountain sickness during subsequent altitude exposure. Acetazolamide causes metabolic acidosis at sea level and altitude, and increases S a O 2...

... supplemented for 3 days on three separate occasions with equivalent quantities of NaCl, NaHCO 3 (metabolic alkalosis) or NH 4 Cl (metabolic acidosis). 2. A significant ( P < 0.025) reduction in bumetanide-induced diuresis (−40%), natriuresis (−21%), and chloruresis (−25%) was observed during NaHCO 3...

...D. Throssell; J. Brown; K. P. G. Harris; J. Walls 1. Metabolic acidosis invariably accompanies chronic renal failure, and short periods of metabolic acidosis cause renal growth and proteinuria in normal rats. Rates of ammoniagenesis are increased in chronic renal failure, and it has been suggested...

...Alan Bevington; Dennis Brough; Frease E. Baker; Jane Hattersley; John Walls 1. During metabolic acidosis, significant fluxes of inorganic phosphate (P i ) may occur from cellular to extracellular fluid. In this study P i was measured in erythrocytes of uraemic patients before and after...

... that parathyroid hormone participates in an important way in the defence against metabolic acidosis. 4. The effects of acidosis, thyroparathyroidectomy and aluminium treatment on renal function parameters were not additive, suggesting a common final mechanism. In normal or acidotic aluminium-treated rats...

...Bryan Williams; Ellis Layward; John Walls 1. Chronic metabolic acidosis is associated with impaired growth and negative nitrogen balance, suggesting that it promotes endogenous protein catabolism. 2. Skeletal muscle is the major repository of body protein and is a potential target for stimuli...

...B. Ludvik; G. Peer; A. Berzlanovich; S. Stifter; H. Graf 1. It has been shown that sodium bicarbonate has no effect or could even be detrimental in various forms of metabolic acidosis. Dichloroacetate, a stimulator of the pyruvate dehydrogenase complex, might offer an alternative treatment...

... differ significantly between the SHR and WKY. 5. Prevention of the development of hypertension in SHR by hydralazine treatment from weaning did not increase pH or bicarbonate compared with untreated SHR, indicating that the metabolic acidosis in the SHR was not a consequence of raised blood pressure. 6...

... metabolic acidosis muscle pH Clinical Science (1985) 69, 505-510 505 Effect of induced metabolic acidosis on intracellular pH, buffer capacity and contraction force of human skeletal muscle E . H U L T M A N * , S. D E L C A N A L E t A N D H. S J O H O L M * *Department of Clinical Chemistry II...

... 12 1982 © 1983 The Biochemical Society and the Medical Research Society 1983 lactic acidosis phenformin heart failure shock diabetes hepatectomy metabolic acidosis Clinical Science (1983) 64,573-580 5 73 Lactic acidosis and the cardiovascular system in the dog ALLEN I. A R I E F...

... of metabolic acidosis produced by the infusion of a molar solution of lactic acid were studied. In the second group the effects of metabolic alkalosis produced by the infusion of a molar solution of sodium bicarbonate were studied. 3. In the acidotic group hepatic arterial blood flow decreased from 35.2 to 9.6...

... increased to meet the increased oxygen demands associated with shivering during the induction of hypothermia. 20 8 1979 8 2 1980 © 1980 The Biochemical Society and the Medical Research Society 1980 heart hypothermia metabolic acidosis oxygen utilization shivering Clinical...

...J. M. Bone; J. Cowie; Anne T. Lambie; J. S. Robson 1. An analysis was made of the relationship which exists between arterial [H + ], P co 2 and [HCO 3 − ] in twenty-five patients with stable metabolic acidosis and alkalosis and in three normal subjects. 2. Contrary to previous reports...

...D. Simon; R. G. Luke 1. Peripheral blood leucocytes were studied before, and 48 h after acute induction in the rat of either uraemia (by bilateral ureteric ligation or bilateral nephrectomy) or of metabolic acidosis in the absence of uraemia (by ingestion of NH 4 Cl). 2. A significant, fourfold...

... clinical situations, so that either index can adequately describe these disturbances. 16 11 1972 © 1973 The Biochemical Society and the Medical Research Society 1973 acid-base balance metabolic acidosis respiratory acidosis carbon dioxide titration curves Clinical Science (1973) 44...