... gluconeogenesis maternal exercise metabolomics To characterize the programming effects of maternal exercise on the gut microbiota composition, 16S rRNA gene sequencing was performed as described in our previous study [ 7 ]. Microbial genomic DNA was extracted from the fecal contents of male offspring...

... metabolomic analysis of plasma before and after ischemia. We also determined cardiac ischemic tolerance in hearts subjected to remote ischemic perconditioning (RIPer) and in hearts ex vivo . Acute ischemia in SHR-CRP markedly increased plasma levels of multiple potent cardioprotective molecules that could...

... 2020 03 09 2020 03 09 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 cardiovascular physiology ischemia metabolomics type 2 diabetes Individuals with Type 2 diabetes mellitus (T2DM) have significantly reduced...

...Rui Xu; Hongwei Zhu; Cuiying Zhang; Guiping Shen; Jianghua Feng The diagnosis of short stature (SS) is of widespread importance for later treatment. In the present paper, a metabolomic method was used to analyze the metabolic characteristics of SS children caused by endocrine metabolic diseases...

... correlated with cGMP levels consistent with a NEP-dependent anti-fibrotic effect. To dissect the molecular mechanisms associated with the anti-fibrotic effects of NEP inhibition, we performed a ‘deep serial analysis of gene expression (Deep SAGE)’ transcriptome and targeted metabolomics analysis of total...

... risk of chronic disease and disability, and reduced healthspan (the period of high functioning healthy life). The plasma metabolome is thought to reflect changes in the activity of physiological systems that influence healthspan. Accordingly, we utilized an LC-MS metabolomics analysis of plasma...

... are joint first authors. † These authors contributed equally to this work. 30 01 2018 09 03 2018 22 03 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 albuminuria cardiovascular disease metabolomics proteomics...

... © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cardiovascular disease chronic kidney disease Gut microbiota heart failure metabolomics The human gut harbors more than 100 trillion microbial cells, and majority of them being...

... for the early detection and prevention of cardiovascular events in addition to new therapeutic strategies to address this residual risk are required if we are to continue to make inroads into this most prevalent of diseases. Metabolomics and lipidomics are modern disciplines that characterize the metabolite...