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Keywords: metformin
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Clin Sci (Lond) (2017) 131 (1): 27–36.
Published: 09 December 2016
...François Cauchy; Mouniya Mebarki; Benjamin Leporq; Samira Laouirem; Miguel Albuquerque; Simon Lambert; Pierre Bourgoin; Olivier Soubrane; Bernard E. Van Beers; Sandrine Faivre; Pierre Bedossa; Valérie Paradis Studies suggest that metformin, widely used for treating Type 2 diabetes, possesses innate...
Includes: Supplementary data
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Clin Sci (Lond) (2012) 122 (12): 555–573.
Published: 05 March 2012
...-zou@ouhsc.edu ). 2 12 2011 12 1 2012 13 1 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 AMP-activated protein kinase (AMPK) autophagy cardiovascular disease energy sensor metformin stress All living organisms face the challenge...
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Clin Sci (Lond) (2012) 122 (6): 253–270.
Published: 11 November 2011
...Benoit Viollet; Bruno Guigas; Nieves Sanz Garcia; Jocelyne Leclerc; Marc Foretz; Fabrizio Andreelli Considerable efforts have been made since the 1950s to better understand the cellular and molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now recommended as the first...
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Clin Sci (Lond) (2009) 116 (8): 607–620.
Published: 16 March 2009
...; consequently, they have been implicated in cardiac ischaemia, arrhythmias and hypertrophy. Recent mechanistic studies have shown that AMPK has an important role in the mechanism of action of MF (metformin), TDZs (thiazolinediones) and statins. Increased understanding of the beneficial effects of AMPK...
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Clin Sci (Lond) (1987) 73 (1): 41–45.
Published: 01 July 1987
...P. Leslie; R. T. Jung; T. E. Isles; J. Baty 1. In the management of the non-insulin dependent diabetic patient, metformin often facilitates weight loss whereas sulphonylurea may predispose to weight gain. To investigate whether this is due to alterations in energy expenditure we have studied energy...