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Keywords: methacholine
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Articles
William J. Anderson, Philip M. Short, Peter A. Williamson, Ashley E. Morrison, Colin Palmer, Roger Tavendale, Brian J. Lipworth
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (1): 75–83.
Published: 09 September 2013
... salbutamol [200 μg q.i.d. (four times daily)], levosalbutamol (100 μg q.i.d.) or placebo on trough methacholine PC 20 [provocative concentration causing 20% fall in FEV 1 (forced expiratory volume in 1 s)] 6 h post-dose (the primary outcome) in 30 persistent asthmatic patients (15 who were Arg 16 homozygous...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2001) 100 (1): 19–23.
Published: 05 December 2000
...A. J. BROWN; J. E. NALLY Angiotensin II potentiates methacholine-evoked bronchoconstriction both in bovine airways in vitro and in asthmatic patients in vivo . Angiotensin II also potentiates endothelin-1-evoked contractions in vitro , but fails to alter such contractions in vivo . One possible...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1999) 96 (3): 253–259.
Published: 01 March 1999
... four times daily). Bronchoprotection against methacholine challenge (as a provocative dose to produce a 20% fall in forced expiratory volume in 1.0 ;s: PD 20 ) was measured at baseline (unprotected) after an initial 1 week run-in without β 2 -agonist, and at 1 ;h after the first and last doses of each...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1998) 95 (5): 611–619.
Published: 01 November 1998
... interacts with other constrictor stimuli. 2. To provide data on this issue, we exposed 17 subjects with asthma to isocapnic hyperventilation of frigid air (HV), methacholine (METH) and histamine (HIS) alone and in combination. 3. With HV (mean ventilation = 55.6±7.7 litres/min), METH (2.20±0.7 ;mmol/l...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1995) 88 (1): 111–117.
Published: 01 January 1995
...P. J. Chowienczyk; J. R. Cockcroft; J. M. Ritter 1. N G -monomethyl-l-arginine (l-NMMA, a nitric oxide synthase inhibitor) inhibits vasodilator responses to acetylcholine but not methacholine in human forearm vasculature. To investigate whether this difference results from the relative...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1993) 85 (1): 51–55.
Published: 01 July 1993
... vascular resistance (ratio between mean arterial blood pressure and forearm blood flow) during three interventions: postocclusive forearm hyperaemia, intrabrachial infusion of methacholine which causes vasodilatation by stimulating the release of endothelium-dependent relaxing factor, and intrabrachial...
Articles
Allan R. Glanville, Conor M. Burke, James Theodore, John C. Baldwin, James Harvey, Antonius Vankessel, Eugene D. Robin
Journal:
Clinical Science
Clin Sci (Lond) (1987) 73 (3): 299–303.
Published: 01 September 1987
...Allan R. Glanville; Conor M. Burke; James Theodore; John C. Baldwin; James Harvey; Antonius Vankessel; Eugene D. Robin 1. Bronchial responsiveness to inhaled methacholine was studied in ten heart-lung transplant (HLT) recipients a mean 10.6 months (range 1.5–28 months) post-HLT and in ten normal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1986) 71 (4): 385–392.
Published: 01 October 1986
... agonists were chosen for study: adenosine with methacholine and PGD 2 with histamine. For each agonist, concentration–s G aw response curves were constructed, from which were derived the provocation concentrations of agonist causing a 25% fall in sGaw from baseline (PC 25 ) and required to further...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (1979) 56 (3): 235–241.
Published: 01 March 1979
... reflex in both groups of subjects. 4. Ipratropium bromide and bupivacaine were tested on methacholine-induced bronchoconstriction in normal and asthmatic subjects. Ipratropium bromide significantly prevented the fall in specific conductance in both groups of subjects whereas bupivacaine (normal subjects...
Articles
Journal:
Clinical Science
Clin Sci (1972) 43 (6): 759–769.
Published: 01 December 1972
...J. F. Cade; M. C. F. Pain 1. Lung function was studied in fifty-six symptom-free asthmatic subjects after the inhalation of urea, an agent not previously used for asthma provocation. The effects of urea were compared with those produced by the inhalation of methacholine and of isoprenaline. 2...