...-adrenergic agonist MTX (methoxamine). Besides promoting hepatic fibrosis, the role of hyperleptinaemia in the modulation of vascular response in NASH (non-alcoholic steatohepatitis) rat livers remains unknown. The aim of the present study was to explore the possible links between hyperleptinaemia...

... of NO and potassium channels by studying the pressor response to methoxamine in rats with carbon tetrachloride-induced cirrhosis with ascites. Experiments were performed in the isolated and perfused mesenteric arterial bed of control rats and of cirrhotic rats with ascites. Pressor responses to methoxamine, an α...

...D. TIGHE; R. MOSS; D. BENNETT 1. We investigated the effect of adrenergic receptor stimulation or inhibition on the hepatic ultrastructural changes in a porcine faecal peritonitis model of multi-organ failure. We infused either the α 1 adrenergic receptor agonist methoxamine or the β 2 adrenergic...

...P. D. Snashall; Frances A. Boother; G. M. Sterling 1. The bronchial response to α-adrenoreceptor stimulation has been investigated in normal and asthmatic subjects with a specific α-receptor agonist, methoxamine hydrochloride, after atropine and β-adrenergic blockade. 2. No significant changes...