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Keywords: methylation
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Clin Sci (Lond) (2023) 137 (16): 1265–1283.
Published: 22 August 2023
... of inflammatory genes in swine STCs. Methods: STCs were harvested from pig kidneys after 10 weeks of RAS or sham ( n =6 each). STC mRNA profiles of inflammatory genes were analyzed using high-throughput mRNA-sequencing (seq) and their DNA methylation (5mC) and hydroxymethylation (5hmC) profiles by DNA...
Includes: Supplementary data
Clin Sci (Lond) (2023) 137 (1): 105–108.
Published: 05 January 2023
..., methylation and phosphorylation. Since the discovery of Set7 as an important regulator of histone H3 lysine 4 methylation state, there has been wide interest in its role in cardiovascular remodeling and cardiac dysfunction. Recent transcriptome and Fourier transform infrared spectroscopy analyses and in vivo...
Clin Sci (Lond) (2020) 134 (15): 2037–2051.
Published: 07 August 2020
...Chunyun Zhang; Shougang Zhuang The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a crucial post-translational modification for many biological processes, including DNA repair, RNA processing, and transduction of intra- and extracellular signaling. Previous...
Clin Sci (Lond) (2020) 134 (2): 261–271.
Published: 29 January 2020
.... Furthermore, we demonstrate that CD48 expression is regulated by methylation and that a hypomethylating agent can increase the CD48 expression, which increases the NK cells killing in vitro . Finally, we show that CD48 high expression can reverse the AML immune evasion and activate NK cells function in vivo...
Includes: Supplementary data
Clin Sci (Lond) (2019) 133 (9): 1085–1096.
Published: 09 May 2019
...Xue-liang Zhou; Zhi-bo Liu; Rong-rong Zhu; Huang Huang; Qi-rong Xu; Hua Xu; Liang Zeng; Yun-yun Li; Cha-hua Huang; Qi-cai Wu; Ji-chun Liu Nuclear receptor binding SET domain 2 (NSD2)-mediated metabolic reprogramming has been demonstrated to regulate oncogenesis via catalyzing the methylation...
Clin Sci (Lond) (2017) 131 (7): 583–594.
Published: 17 March 2017
.... The mechanism of CAE remains unclear, and its treatment is limited. Previous studies have shown that risk factors for CAE were related to changes in DNA methylation. However, no systematic investigation of methylation profiles has been performed. Therefore, we compared methylation profiles between 12 CAE...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (13): 1051–1063.
Published: 23 May 2016
... for muscle metabolic processes. Substantial evidence is emerging that highlights the importance of epigenetic mechanisms in this process. This review will examine the importance of epigenetics in the regulation of muscle metabolism, with a particular emphasis on DNA methylation and histone acetylation...