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Keywords: methylglyoxal
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Clin Sci (Lond) (2016) 130 (19): 1677–1696.
Published: 23 August 2016
... metabolism of dicarbonyl metabolites. MG (methylglyoxal) is a dicarbonyl metabolite of relatively high flux of formation and precursor of the most quantitatively and functionally important spontaneous modifications of protein and DNA clinically. Major MG-derived adducts are arginine-derived hydroimidazolones...
Clin Sci (Lond) (2015) 128 (12): 839–861.
Published: 27 March 2015
...Dionne E.M. Maessen; Coen D.A. Stehouwer; Casper G. Schalkwijk The formation and accumulation of advanced glycation endproducts (AGEs) are related to diabetes and other age-related diseases. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, is the major precursor in the formation of AGEs...
Clin Sci (Lond) (1996) 91 (5): 575–582.
Published: 01 November 1996
... correlated positively with haemoglobin A 1c in diabetic patients. In insulin-dependent patients, the concentration of methylglyoxal was also in the logistic model for retinopathy and diabetic complications, but the logistic regression coefficient was not significant. 3. Multiple linear regression analysis...
Clin Sci (Lond) (1994) 87 (1): 21–29.
Published: 01 July 1994
...Antony C. McLellan; Paul J. Thornalley; Jonathan Benn; Peter H. Sonksen 1. The metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic complications. The glyoxalase system was characterized in blood samples from patients with insulin-dependent diabetes...