... was found in normal subjects. 4. It is suggested that methylnoradrenaline may accumulate in peripheral nerve endings of patients with essential hypertension in comparison with normal subjects, and this accumulated methylnoradrenaline potentiates the pressor response to dopamine in essential hypertension...

...-dihydroxyphenylalanine (methyldopa) is largely mediated through an activation by its metabolite, methylnoradrenaline, of noradrenaline mechanisms in the lower brain stem. The central noradrenaline agonist, clonidine, probably acts in an analogous way although some evidence indicates that this drug may influence blood...