...Alastair J. McCance; J. Colin Forfar 1. To investigate the effects of acute β 1 -adrenoceptor blockade on sympathetic nervous activity, cardiac and whole-body noradrenaline kinetics were determined during intravenous infusions of saline placebo and of metoprolol (10-15 mg plus 150 μg min −1 kg −1...

...P. E. Hall; S. R. Smith; M. J. Kendall 1. Plasma ammonia and heart rate were measured in normal volunteers before, during and after an exercise test following administration of placebo, propranolol, pindolol, metoprolol and nadolol. 2. Small changes in plasma ammonia occurred during exercise after...

... and β-adrenergic blockade with atropine and metoprolol. 2. From rest to exercise at fatigue, systolic, diastolic and mean arterial pressures increased by 32 ± 4 and 39 ± 3 mmHg, 24 ± 3 and 26 ± 4 mmHg, and 26 ± 3 and 30 ± 3 mmHg respectively for static and dynamic handgrip. There were no significant...

...W. Kirch; H. Spahn; H. Köhler; E. Mutschler 1. Pharmacokinetics of metoprolol, propranolol and atenolol were investigated in six healthy volunteers after 7 days of oral monotherapy with these drugs and after 7 days concurrent administration, with each of these β-adrenoceptor antagonists...

...I. A. Macdonald; T. Bennett; E. A. M. Gale; J. Hilary Green; S. Walford 1. The effects of metoprolol and propranolol on heat production and body temperature have been studied in six male subjects during insulin-induced hypoglycaemia in a thermoneutral environment. Hypoglycaemia was induced...

... with metoprolol tartrate (2.5 mg/kg, intraperitoneally, twice daily) prevented the elevation in blood pressure induced by adrenaline from osmotic minipumps. Such metoprolol treatment did not affect the blood pressure of control rats. 3. Noradrenaline administered intraperitoneally from osmotic minipumps...

...J. M. Cruickshank; G. Neil-Dwyer; M. M. Cameron; J. McAinsh 1. Sixteen neurosurgical patients received (oral) β-adrenoreceptor-blocking agents (β-receptor blockers) for 3–22 days. 2. Lipophilic β-receptor blockers (propranolol) and metoprolol appeared in cerebrospinal fluid at concentrations...

...H. Houben; TH. Thien; TH. De Boo; W. Lemmens; C. L. A. Van Herwaarden; J. F. M. Fennis; A. Van 'T Laar 1. Haemodynamic effects of adrenaline were studied in 27 hypertensive patients, successively during treatment with propranolol and metoprolol. In 12 patients β-adrenoreceptor blockade was combined...

...F. G. Dunn; A. R. Lorimer; T. D. V. Lawrie 1. A standardized method of objectively measuring performance during simulated car driving is described. 2. The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension...

...S. Mann; M. W. Millar Craig; D. G. Altman; D. I. Melville; E. B. Raftery 1. Continuous monitoring of arterial pressure was performed via an indwelling cannula over 24 h in 12 hypertensive patients before treatment and again 2–4 months after starting metoprolol (100 mg twice daily). 2. During...

...S.-L. Boström; J. Fryklund 1. Propranolol and metoprolol were given in the diet of spontaneously hypertensive (SH) rats during the development of hypertension. 2. At the early established phase of hypertension, protein synthesis and protein composition of the left ventricle, aorta, mesenteric...

...J. B. Stoker; N. Sreeharan; R. J. Linden; M. P. Barbour; A. R. Lorimer; W. S. Hillis; T. D. V. Lawrie 1. The adequacy of the control of essential hypertension during exercise was studied in patients whose resting blood pressure had been controlled for 1 year with either metoprolol or methyldopa. 2...

...D. L. Clement 1. Dose—response curves of isoprenaline were constructed in nine hypertensive patients before and after either propranolol or metoprolol. 2. The decrease of diastolic blood pressure and increase of heart rate with isoprenaline were significantly more inhibited by propranolol than...

...J. D. F. England; A. S. P. Hua; J. Shaw 1. Chlorothiazide twice a day plus atenolol, metoprolol, pindolol and propranolol in single daily doses administered to patients with essential hypertension achieved effective control of blood pressure. 2. Each β-adrenoreceptor-blocking drug was associated...

...B. Ljung; B. Åblad; L. Drews; E. Fellenius; A. Kjellstedt; M. Wallborg 1. Oral and intravenous administration of metoprolol to adult spontaneously hypertensive rats (SHR) with established hypertension lowered arterial blood pressure within 4 days of treatment. 2. Steady-state plasma concentrations...

...A. Jäättelä; K. Pyörälä 1. A double-blind cross-over evaluation of the anti-hypertensive effect of metoprolol vs placebo was carried out in a series of twenty-three patients with mild or moderate essential hypertension who were receiving 25 mg of chlorthalidone daily as their basic treatment...

...G. W. Viol; E. K. M. Smith; J. D. Fitzgerald 1. Acute oral administration of metoprolol and propranolol to ten normal males resulted in equal reduction in heart rate both supine and after passive tilting to 60°. 2. Tilted systolic blood pressure was reduced by both agents but metoprolol alone...

...P. Lund-Johansen; O. J. Ohm 1. Oxygen consumption and central haemodynamics were recorded at rest and during exercise in fifty-one men with essential hypertension (W.H.O. stage I) and repeated after 1 year on a single drug: alprenolol ( n = 10), atenolol (13) metoprolol (12) and timolol (16). 2...

...-adrenoreceptor antagonists hypertension metoprolol oxprenolol practolol propranolol tolamolol Clinical Science and Molecular Medicine (1976) 51, 541tS44s. Comparative anti-hypertensive effectiveness of padrenoreceptor antagonists with different pharmacological properties: dose-response studies during...