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1-45 of 45
Keywords: microRNA
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Articles
Soumyalekshmi Nair, Valeska Ormazabal, Flavio Carrion, Aase Handberg, H David McIntyre, Carlos Salomon
Journal:
Clinical Science
Clin Sci (Lond) (2023) 137 (16): 1311–1332.
Published: 31 August 2023
... for this article was enabled by the participation of University of Queensland in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with CAUL. Extracellular Vesicles insulin resistance microRNA Pregnancy skeletal muscle...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (18): 1341–1346.
Published: 21 September 2022
...Jessica L. Faulkner; Jennifer C. Sullivan MicroRNA (miRNA) are small, single strand non-coding RNA molecules involved in the post-transcriptional regulation of target genes. Since their discovery in 1993, over 2000 miRNAs have been identified in humans and there is growing interest in both...
Articles
Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (17): 1281–1301.
Published: 05 September 2022
... response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled...
Includes: Supplementary data
Articles
Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Luca Salerno, Nadia Salerno, Konrad Urbanek, Daniele Torella
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (16): 1179–1203.
Published: 18 August 2022
... that require sequential activation and/or repression of different genetic programs. Therefore, CM differentiation and specification have been depicted as a step-wise specific chemical and mechanical stimuli inducing complete myogenic commitment and cell-cycle exit. Yet, the demonstration that some microRNAs...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (12): 911–934.
Published: 20 June 2022
... transcription factor family and microRNAs on the regulation of positive and negative cell cycle factors is discussed. This review also highlights seminal studies that identified the coordination of signaling mechanisms that can potently activate CM cell cycle re-entry including the Wnt/Ctnnb1, Hippo, Pi3K-Akt...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 621–637.
Published: 27 April 2022
... 12 04 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 atrial fibrillation microRNA small extracellular vesicles Correspondence: Boyoung Joung ( cby6908@yuhs.ac ) or Young-Nam Youn ( ynyoun@yuhs.ac ) The mean size...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (8): 579–597.
Published: 21 April 2022
...) components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNAs) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (5): 345–360.
Published: 09 March 2022
... with altered expression of mitochondria-related microRNAs (mitomiRs), which localize in mitochondria and regulate the expression of mtDNA and nucleus-encoded mitochondrial genes. This review summarizes relevant evidence regarding the involvement of renal mitochondrial injury and dysfunction in frequent forms...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2022) 136 (5): 323–328.
Published: 02 March 2022
...Carlos J. Pirola; Silvia Sookoian MicroRNAs (miRNAs), which are regarded as crucial regulators of gene expression and diverse aspects of cell biology, can be present in various body fluids as highly stable molecules. It is also known that miRNAs exert tissue-specific regulation of gene...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2021) 135 (12): 1487–1503.
Published: 17 June 2021
..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (21): 2893–2895.
Published: 13 November 2020
... 10.1681/ASN.2008070798 19389847 4. Collino F. , Bruno S. , Incarnato D. , Dettori D. , Neri F. , Provero P. et al . ( 2015 ) AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs . J. Am. Soc. Nephrol. 26 , 2349...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (8): 1001–1025.
Published: 27 April 2020
...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (8): 955–959.
Published: 21 April 2020
... vesicle Exo exosome miRNA microRNA TNM Tumor Node Metastasis References 1. Battaglin F. , Puccini A. , Intini R. , Schirripa M. , Ferro A. , Bergamo F. et al . ( 2018 ) The role of tumor angiogenesis as a therapeutic target in colorectal...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 169–192.
Published: 23 January 2020
... for the development of biomarkers to identify at-risk asymptomatic carotid plaque prior to disease progression and stroke. Further, it would aid in creation of therapeutics to stabilize carotid plaque. MicroRNAs (miRNAs) have been implicated as key protagonists in various stages of atherosclerotic plaque initiation...
Articles
In Collection
Clinical and translational research highlights
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (2): 87–101.
Published: 21 January 2020
... Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . acute coronary syndrome microRNA preeclampsia RNA sequencing Preeclampsia (PE) is estimated to affect up to 8% of all pregnancies worldwide, and thus represents a substantial burden on the cardiovascular...
Includes: Supplementary data
Articles
Silvija Cvitic, Jasmin Strutz, Hannah M. Appel, Elisa Weiß, Waltraud T. Brandl, Andrea Thüringer, Eva M. Bernhart, Luciana Lassance, Christian Wadsack, Carolin Schliefsteiner, Ivana Sreckovic, Karl Kashofer, Ursula Hiden
Journal:
Clinical Science
Clin Sci (Lond) (2020) 134 (1): 39–51.
Published: 06 January 2020
... males and females. Besides the action of estrogen, sex chromosome gene expression and programming effects also provoke this sexual dimorphism. MicroRNAs (miRNAs) have emerged as regulators of endothelial cell function and dysfunction. We here hypothesized distinct miRNA expression patterns in male...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (21): 2217–2220.
Published: 13 November 2019
... in mouse models of neointimal hyperplasia where c-myb is up-regulated [ 24 ]. These contrasting findings might be explained by differences in temporospatial expression of microRNA-143/145 or negative regulation of Dicer processing of miR-143/145 in the context of atherosclerosis [ 24 ]. To serve...
Articles
Fumiko Nakazeki, Itaru Tsuge, Takahiro Horie, Keiko Imamura, Kayoko Tsukita, Akitsu Hotta, Osamu Baba, Yasuhide Kuwabara, Tomohiro Nishino, Tetsushi Nakao, Masataka Nishiga, Hitoo Nishi, Yasuhiro Nakashima, Yuya Ide, Satoshi Koyama, Masahiro Kimura, Shuhei Tsuji, Motoko Naitoh, Shigehiko Suzuki, Yuishin Izumi, Toshitaka Kawarai, Ryuji Kaji, Takeshi Kimura, Haruhisa Inoue, Koh Ono
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (4): 583–595.
Published: 22 February 2019
...; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2019) 133 (1): 23–40.
Published: 03 January 2019
... carried out in humans. adipocytes exosomes MicroRNA metabolism non-coding RNAs Obesity is a worldwide epidemic that arises as a chronic long-term imbalance between calorie intake and energy expenditure. Despite nutritional interventions and physical education programmes, the prevalence...
Articles
Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2451–2467.
Published: 30 November 2018
.... Subsequently, this file was analyzed using the miRDeep2 program to identify known miRNAs [ 28 ]. The miRDeep2 algorithm requires a genomic index and microRNA database to perform analysis. The human genome (version 19) pre-built index was obtained from the bowtie website ( http://bowtie-bio.sourceforge.net...
Includes: Supplementary data
Articles
Jasmin Strutz, Silvija Cvitic, Hubert Hackl, Karl Kashofer, Hannah M. Appel, Andrea Thüringer, Gernot Desoye, Pieter Koolwijk, Ursula Hiden
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2437–2449.
Published: 22 November 2018
...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...
Includes: Supplementary data
Articles
Alessandra Magenta, Sara Sileno, Marco D’Agostino, Francesca Persiani, Sara Beji, Alessandra Paolini, Daniele Camilli, Alessandro Platone, Maurizio C. Capogrossi, Sergio Furgiuele
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (22): 2423–2436.
Published: 22 November 2018
... dysfunction inflammation microRNA Atherosclerosis and the presence of unstable plaques at carotid bifurcation is responsible for approximately 15–20% of all cerebrovascular events [ 1 ]. Vulnerable or rupture-prone plaques are characterised by a large cholesterol-rich core, are poor in calcium...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (17): 1875–1888.
Published: 05 September 2018
... in the cytoplasm or generated de novo upon platelet activation. atherosclerosis microRNA platelet adhesion and activation Platelets play an important role in the control of vascular homeostasis. Indeed, beyond their function in hemostasis, they can transmit inflammatory signals and secrete...
Articles
Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network
Journal:
Clinical Science
Clin Sci (Lond) (2018) 132 (9): 925–942.
Published: 21 May 2018
... hypertrophy, see [ 39 , 40 ]. Correspondence: Yvan Devaux ( yvan.devaux@lih.lu ) 05 02 2018 12 04 2018 16 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 biomarkers cardiovascular disease microRNA non-coding...
Articles
Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Jr, Xiaoyun Hu, Da-Zhi Wang
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (24): 2885–2900.
Published: 04 December 2017
...@enders.tch.harvard.edu ) 18 09 2017 01 11 2017 03 11 2017 03 11 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 adipocytes cardiac hypertrophy dyslipidemia high fat diet microRNA obesity The incidence of obesity has...
Includes: Supplementary data
Articles
Ricardo Cambraia Parreira, Leandro Heleno Guimarães Lacerda, Rebecca Vasconcellos, Swiany Silveira Lima, Anderson Kenedy Santos, Vanessa Fontana, Valéria Cristina Sandrim, Rodrigo Ribeiro Resende
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (23): 2813–2834.
Published: 28 November 2017
... 2017 microRNA resistant hypertension Signaling Pathways Resistant hypertension (RH) is characterized by a condition in which the patient requires four or more antihypertensive medications, including a diuretic, regardless of blood pressure (BP) control. RH patients can be classified...
Articles
Marco D’Agostino, Francesco Martino, Sara Sileno, Francesco Barillà, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio Colognesi Capogrossi, Alessandra Magenta
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (18): 2397–2408.
Published: 08 September 2017
... hypercholesterolaemia microRNA miR-200c miR-33 oxidative stress paediatrics Zinc Finger E-box-Binding Homeobox 1 miRNAs are short, non-coding RNA molecules, that modulate the stability and/or the translational efficiency of target mRNAs [ 1 , 2 ]. They have been linked to different diseases and given...
Includes: Supplementary data
Articles
Mamoru Satoh, Takahito Nasu, Yuji Takahashi, Takuya Osaki, Sho Hitomi, Yoshihiro Morino, Motoyuki Nakamura
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 2007–2017.
Published: 13 July 2017
... ( satohm@iwate-med.ac.jp ) 24 03 2017 07 06 2017 23 06 2017 23 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere...
Articles
Steven Horsburgh, Nicola Fullard, Mathilde Roger, Abbie Degnan, Stephen Todryk, Stefan Przyborski, Steven O’Reilly
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (15): 1923–1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...
Articles
Anna Witasp, Amaryllis H. Van Craenenbroeck, Paul G. Shiels, Tomas J. Ekström, Peter Stenvinkel, Louise Nordfors
Journal:
Clinical Science
Clin Sci (Lond) (2017) 131 (14): 1649–1667.
Published: 30 June 2017
... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD...
Articles
Amalia Forte, Barbara Rinaldi, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (11): 615–634.
Published: 25 July 2014
... proliferative disease. Although the main molecular and cellular mechanisms underlying restenosis have been well described, new signalling molecules and cell types controlling the progress of restenosis are continuously being discovered. In particular, microRNAs and vascular progenitor cells have recently been...
Articles
Anke Nijhuis, Paolo Biancheri, Amy Lewis, Cleo L. Bishop, Paolo Giuffrida, Christopher Chan, Roger Feakins, Richard Poulsom, Antonio Di Sabatino, Gino Roberto Corazza, Thomas T. MacDonald, James O. Lindsay, Andrew R. Silver
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (5): 341–350.
Published: 15 May 2014
... microRNA miR-29 stricture 1 These authors contributed equally to the study. Correspondence: Professor Andrew R. Silver (email a.silver@qmul.ac.uk ) or Dr James O. Lindsay (email james.lindsay@bartshealth.nhs.uk ). 17 1 2014 26 2 2014 18 3 2014 18 3 2014...
Includes: Supplementary data
Articles
Federica Savi, Irene Forno, Alice Faversani, Andrea Luciani, Sarah Caldiera, Stefano Gatti, Paolo Foa, Dario Ricca, Gaetano Bulfamante, Valentina Vaira, Silvano Bosari
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (4): 233–242.
Published: 10 April 2014
...) or strong (3) expressors. breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being a deeply characterized neoplasia with disclosed molecular signatures, it remains the second largest cause of cancer death in women. Deregulation...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 127 (2): 77–89.
Published: 17 March 2014
...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (6): 377–400.
Published: 15 November 2013
... drugs. Correspondence: Dr Helen Maddock ( apx281@coventry.ac.uk ). 16 11 2012 22 8 2013 23 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biomarker cancer-therapy-induced cardiotoxicity early clinical assessment microRNA subclinical...
Articles
Valentina Vaira, Leda Roncoroni, Donatella Barisani, Gabriella Gaudioso, Silvano Bosari, Gaetano Bulfamante, Luisa Doneda, Dario Conte, Carolina Tomba, Maria Teresa Bardella, Stefano Ferrero, Martina Locatelli, Luca Elli
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (6): 417–423.
Published: 15 November 2013
..., which is characterized by an immunological reaction against gluten and transglutaminase in genetically predisposed subjects. However, the molecular determinants underpinning CD pathogenesis are yet to be fully elucidated and little data are available about the involvement of miRNAs (microRNAs) in CD...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2014) 126 (2): 123–138.
Published: 13 September 2013
....it ). 27 2 2013 24 6 2013 15 7 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 endometriosis epigenetics epithelial progenitor cell mesenchymal stromal cell microRNA stem cell marker There is well-established evidence that, although endometriosis...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 125 (4): 151–166.
Published: 26 April 2013
...Enzo R. Porrello Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2013) 124 (1): 27–40.
Published: 07 September 2012
... study was performed to determine the function of miR-29b (microRNA-29b) in trophoblast cells and its underlying role in the pathogenesis of PE. The prediction of miR-29b target genes was performed using computer-based programs, including Targetscan, Pictar and miRBase. The function of these target genes...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2012) 123 (11): 611–625.
Published: 01 August 2012
...Katarzyna Goljanek-Whysall; Dylan Sweetman; Andrea E. Münsterberg miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (10): 437–447.
Published: 25 July 2011
...Tengfei Zhang; Qiming Wang; Dan Zhao; Yaling Cui; Bangrong Cao; Liping Guo; Shih Hsin Lu miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate the role of miR-31 in ESCC (oesophageal squamous cell carcinoma). We measured miR-31 in 45 paired...
Includes: Supplementary data
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2011) 121 (4): 141–158.
Published: 20 April 2011
.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic...
Articles
Junhao Gui, Yaping Tian, Xinyu Wen, Wenhui Zhang, Pengjun Zhang, Jing Gao, Wei Run, Liyuan Tian, Xingwang Jia, Yanhong Gao
Journal:
Clinical Science
Clin Sci (Lond) (2011) 120 (5): 183–193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
Articles
Yunhui Cheng, Ning Tan, Jian Yang, Xiaojun Liu, Xiaopei Cao, Pengcheng He, Xiaoli Dong, Shanshan Qin, Chunxiang Zhang
Journal:
Clinical Science
Clin Sci (Lond) (2010) 119 (2): 87–95.
Published: 20 April 2010
...Yunhui Cheng; Ning Tan; Jian Yang; Xiaojun Liu; Xiaopei Cao; Pengcheng He; Xiaoli Dong; Shanshan Qin; Chunxiang Zhang miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively...
Articles
Journal:
Clinical Science
Clin Sci (Lond) (2008) 114 (12): 699–706.
Published: 14 May 2008
...Chunxiang Zhang miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system...