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Articles

Circulating cell-free micro-RNA as biomarkers: from myocardial infarction to hypertension

Jessica L. Faulkner, Jennifer C. Sullivan

Clin Sci (Lond) (2022) 136 (18): 1341–1346.

DOI: https://doi.org/10.1042/CS20220056

Published: 21 September 2022

...Jessica L. Faulkner; Jennifer C. Sullivan MicroRNA (miRNA) are small, single strand non-coding RNA molecules involved in the post-transcriptional regulation of target genes. Since their discovery in 1993, over 2000 miRNAs have been identified in humans and there is growing interest in both...

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Articles

Multicellular regulation of miR-196a-5p and miR-425-5 from adipose stem cell-derived exosomes and cardiac repair

Nathalia C. de Almeida Oliveira, Elida A. Neri, Caio M. Silva, Iuri C. Valadão, Miriam H. Fonseca-Alaniz, Camila Zogbi, Débora Levy, Sergio P. Bydlowski, Jose Eduardo Krieger

Clin Sci (Lond) (2022) 136 (17): 1281–1301.

DOI: https://doi.org/10.1042/CS20220216

Published: 05 September 2022

... response. Biomolecules secreted or shuttled within extracellular vesicles, such as exosomes, may participate in the concerted response. We investigated the exosome’s microRNAs due to their capacity to fine-tune gene expression, potentially affecting the multicellular repair response. We profiled...

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Articles

The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation

Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Luca Salerno, Nadia Salerno, Konrad Urbanek, Daniele Torella

Clin Sci (Lond) (2022) 136 (16): 1179–1203.

DOI: https://doi.org/10.1042/CS20220391

Published: 18 August 2022

... that require sequential activation and/or repression of different genetic programs. Therefore, CM differentiation and specification have been depicted as a step-wise specific chemical and mechanical stimuli inducing complete myogenic commitment and cell-cycle exit. Yet, the demonstration that some microRNAs...

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Articles

Defining the molecular underpinnings controlling cardiomyocyte proliferation

Donya Mahiny-Shahmohammady, Ludger Hauck, Filio Billia

Clin Sci (Lond) (2022) 136 (12): 911–934.

DOI: https://doi.org/10.1042/CS20211180

Published: 20 June 2022

... transcription factor family and microRNAs on the regulation of positive and negative cell cycle factors is discussed. This review also highlights seminal studies that identified the coordination of signaling mechanisms that can potently activate CM cell cycle re-entry including the Wnt/Ctnnb1, Hippo, Pi3K-Akt...

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Articles

Small extracellular vesicles derived from patients with persistent atrial fibrillation exacerbate arrhythmogenesis via miR-30a-5p

Dasom Mun, Hyoeun Kim, Ji-Young Kang, Nuri Yun, Young-Nam Youn, Boyoung Joung

Clin Sci (Lond) (2022) 136 (8): 621–637.

DOI: https://doi.org/10.1042/CS20211141

Published: 27 April 2022

... Correspondence: Boyoung Joung ( cby6908@yuhs.ac ) or Young-Nam Youn ( ynyoun@yuhs.ac ) AF atrial fibrillation AF-sEVs sEVs were isolated from patients with persistent AF CaMKII calcium/calmodulin-dependent protein kinase II miRNA microRNA non-AF-sEVs sEVs were isolated from...

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Includes: Supplementary data

Articles

A time to heal: microRNA and circadian dynamics in cutaneous wound repair

Sandra Fawcett, Raida Al Kassas, Iain M Dykes, Alun TL Hughes, Fawaz Ghali, Kehinde Ross

Clin Sci (Lond) (2022) 136 (8): 579–597.

DOI: https://doi.org/10.1042/CS20220011

Published: 21 April 2022

...) components such as such as collagen. Recent years have seen huge increases in our understanding of the functions of microRNAs (miRNAs) in wound repair. Concomitantly, there has been growing recognition of miRNA roles in circadian processes, either as regulators or targets of clock activity or direct...

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Articles

Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and mitomiRs

Maria V. Irazabal, Alejandro R. Chade, Alfonso Eirin

Clin Sci (Lond) (2022) 136 (5): 345–360.

DOI: https://doi.org/10.1042/CS20210512

Published: 09 March 2022

... with altered expression of mitochondria-related microRNAs (mitomiRs), which localize in mitochondria and regulate the expression of mtDNA and nucleus-encoded mitochondrial genes. This review summarizes relevant evidence regarding the involvement of renal mitochondrial injury and dysfunction in frequent forms...

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Articles

MicroRNAs as messengers of liver diseases: has the message finally been decrypted?

Carlos J. Pirola, Silvia Sookoian

Clin Sci (Lond) (2022) 136 (5): 323–328.

DOI: https://doi.org/10.1042/CS20211177

Published: 02 March 2022

...Carlos J. Pirola; Silvia Sookoian MicroRNAs (miRNAs), which are regarded as crucial regulators of gene expression and diverse aspects of cell biology, can be present in various body fluids as highly stable molecules. It is also known that miRNAs exert tissue-specific regulation of gene...

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Articles

Cancer therapy-related cardiac dysfunction: is endothelial dysfunction at the heart of the matter?

Crizza Ching, Dakota Gustafson, Paaladinesh Thavendiranathan, Jason E. Fish

Clin Sci (Lond) (2021) 135 (12): 1487–1503.

DOI: https://doi.org/10.1042/CS20210059

Published: 17 June 2021

..., and the initiating mechanisms remain incompletely understood. More recently, circulating inflammatory markers, cardiac biomarkers, microRNAs, and extracellular vesicles (EVs) have been considered as early markers of cardiovascular injury. Concomitantly, the role of the endothelium in regulating cardiac function...

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Articles

Extracellular RNA in kidney disease: moving slowly but surely from bench to bedside

Robert W. Hunter, Neeraj Dhaun

Clin Sci (Lond) (2020) 134 (21): 2893–2895.

DOI: https://doi.org/10.1042/CS20201092

Published: 13 November 2020

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . microRNA renal physiology therapeutics The renal tubular epithelial cell (rTEC) has been well-characterised with respect to its ability to release and take up extracellular RNA (exRNA) and EVs [ 1...

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Articles

From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia

Sonya Frazier, Martin W. McBride, Helen Mulvana, Delyth Graham

Clin Sci (Lond) (2020) 134 (8): 1001–1025.

DOI: https://doi.org/10.1042/CS20200023

Published: 27 April 2020

...Sonya Frazier; Martin W. McBride; Helen Mulvana; Delyth Graham Placental microRNAs (miRNAs) regulate the placental transcriptome and play a pathological role in preeclampsia (PE), a hypertensive disorder of pregnancy. Three PE rodent model studies explored the role of placental miRNAs, miR-210, miR...

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Articles

DLC-1 down-regulation via exosomal miR-106b-3p exchange promotes CRC metastasis by the epithelial-to-mesenchymal transition

Francesco Mannavola, Gaetano Pezzicoli, Marco Tucci

Clin Sci (Lond) (2020) 134 (8): 955–959.

DOI: https://doi.org/10.1042/CS20200181

Published: 21 April 2020

... the adhesion of neighboring metastatic cells: Role of microRNA-210 . Cancer Biol. Ther. 17 , 1062 – 1069 10.1080/15384047.2016.1219815 27611932 10. Liu H. , Liu Y. , Sun P. , Leng K. , Xu Y. , Mei L. et al . ( 2020 ) Colorectal cancer-derived exosomal miR-106b...

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Articles

MicroRNAs as sentinels and protagonists of carotid artery thromboembolism

Sneha Raju, Jason E. Fish, Kathryn L. Howe

Clin Sci (Lond) (2020) 134 (2): 169–192.

DOI: https://doi.org/10.1042/CS20190651

Published: 23 January 2020

... for the development of biomarkers to identify at-risk asymptomatic carotid plaque prior to disease progression and stroke. Further, it would aid in creation of therapeutics to stabilize carotid plaque. MicroRNAs (miRNAs) have been implicated as key protagonists in various stages of atherosclerotic plaque initiation...

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Articles

Circulating miR-206 and Wnt-signaling are associated with cardiovascular complications and a history of preeclampsia in women

Kenny Schlosser, Amanpreet Kaur, Natalie Dayan, Duncan J. Stewart, Louise Pilote, Christian Delles

Clin Sci (Lond) (2020) 134 (2): 87–101.

DOI: https://doi.org/10.1042/CS20190920

Published: 21 January 2020

... coronary syndrome microRNA preeclampsia RNA sequencing Preeclampsia (PE) is estimated to affect up to 8% of all pregnancies worldwide, and thus represents a substantial burden on the cardiovascular health of millions of women [ 1 ]. While the high blood pressure and proteinuria associated...

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Articles

Sexual dimorphism of miRNA signatures in feto-placental endothelial cells is associated with altered barrier function and actin organization

Silvija Cvitic, Jasmin Strutz, Hannah M. Appel, Elisa Weiß, Waltraud T. Brandl, Andrea Thüringer, Eva M. Bernhart, Luciana Lassance, Christian Wadsack, Carolin Schliefsteiner, Ivana Sreckovic, Karl Kashofer, Ursula Hiden

Clin Sci (Lond) (2020) 134 (1): 39–51.

DOI: https://doi.org/10.1042/CS20190379

Published: 06 January 2020

... males and females. Besides the action of estrogen, sex chromosome gene expression and programming effects also provoke this sexual dimorphism. MicroRNAs (miRNAs) have emerged as regulators of endothelial cell function and dysfunction. We here hypothesized distinct miRNA expression patterns in male...

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Articles

A tangled tale of microRNA and cardiac fibrosis

Mark Chandy

Clin Sci (Lond) (2019) 133 (21): 2217–2220.

DOI: https://doi.org/10.1042/CS20190866

Published: 13 November 2019

... ]. Correspondence: Mark Chandy ( mjchandy@stanford.edu ) 01 10 2019 29 10 2019 30 10 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA The clinical assessment of cardiac fibrosis...

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Articles

MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons

Clin Sci (Lond) (2019) 133 (4): 583–595.

DOI: https://doi.org/10.1042/CS20180980

Published: 22 February 2019

...; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic...

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Articles

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

Silvia Lorente-Cebrián, Pedro González-Muniesa, Fermín I. Milagro, J. Alfredo Martínez

Clin Sci (Lond) (2019) 133 (1): 23–40.

DOI: https://doi.org/10.1042/CS20180890

Published: 03 January 2019

... carried out in humans. Correspondence: Silvia Lorente-Cebrián ( slorente@unav.es ) 11 10 2018 29 11 2018 05 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipocytes exosomes MicroRNA metabolism non...

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Articles

Human placental exosomes in gestational diabetes mellitus carry a specific set of miRNAs associated with skeletal muscle insulin sensitivity

Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Carlos Palma, Katherin Scholz-Romero, Omar Elfeky, Felipe Zuñiga, Valeska Ormazabal, Emilio Diaz, Gregory E. Rice, Gregory Duncombe, Thomas Jansson, Harold David McIntyre, Martha Lappas, Carlos Salomon

Clin Sci (Lond) (2018) 132 (22): 2451–2467.

DOI: https://doi.org/10.1042/CS20180487

Published: 30 November 2018

... 09 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Maternal metabolism undergoes dynamic changes in pregnancy to ensure an adequate supply of metabolites...

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Articles

Gestational diabetes alters microRNA signatures in human feto-placental endothelial cells depending on fetal sex

Jasmin Strutz, Silvija Cvitic, Hubert Hackl, Karl Kashofer, Hannah M. Appel, Andrea Thüringer, Gernot Desoye, Pieter Koolwijk, Ursula Hiden

Clin Sci (Lond) (2018) 132 (22): 2437–2449.

DOI: https://doi.org/10.1042/CS20180825

Published: 22 November 2018

...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...

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Articles

Atherosclerotic plaque instability in carotid arteries: miR-200c as a promising biomarker

Alessandra Magenta, Sara Sileno, Marco D’Agostino, Francesca Persiani, Sara Beji, Alessandra Paolini, Daniele Camilli, Alessandro Platone, Maurizio C. Capogrossi, Sergio Furgiuele

Clin Sci (Lond) (2018) 132 (22): 2423–2436.

DOI: https://doi.org/10.1042/CS20180684

Published: 22 November 2018

...). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis endothelial dysfunction inflammation microRNA Atherosclerosis and the presence of unstable plaques at carotid bifurcation is responsible for approximately 15–20% of all cerebrovascular events [ 1...

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Articles

Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs

Voahanginirina Randriamboavonjy, Ingrid Fleming

Clin Sci (Lond) (2018) 132 (17): 1875–1888.

DOI: https://doi.org/10.1042/CS20180580

Published: 05 September 2018

... on behalf of the Biochemical Society 2018 atherosclerosis microRNA platelet adhesion and activation Platelets are discoid anuclear cells produced by megakaryocytes; while the bone marrow is the classical and most important site of proplatelet formation and platelet biogenesis [ 1...

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Articles

Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system

Clarissa P.C. Gomes, David de Gonzalo-Calvo, Rocio Toro, Tiago Fernandes, Daniel Theisen, Da-Zhi Wang, Yvan Devaux, on behalf of the Cardiolinc™ network

Clin Sci (Lond) (2018) 132 (9): 925–942.

DOI: https://doi.org/10.1042/CS20171463

Published: 21 May 2018

... controls [ 91 ]. Figure 2 Exercise-induced adaptations mediated by miRNAs in heart, skeletal muscle and circulation biomarkers cardiovascular disease microRNA non-coding RNA physical exercise therapeutics Similar to cardiac muscle tissue, miRNAs play a pivotal role...

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Articles

Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy

Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Jr, Xiaoyun Hu, Da-Zhi Wang

Clin Sci (Lond) (2017) 131 (24): 2885–2900.

DOI: https://doi.org/10.1042/CS20171368

Published: 04 December 2017

...@enders.tch.harvard.edu ) 18 09 2017 01 11 2017 03 11 2017 03 11 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 adipocytes cardiac hypertrophy dyslipidemia high fat diet microRNA obesity The incidence of obesity has...

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Articles

Decoding resistant hypertension signalling pathways

Ricardo Cambraia Parreira, Leandro Heleno Guimarães Lacerda, Rebecca Vasconcellos, Swiany Silveira Lima, Anderson Kenedy Santos, Vanessa Fontana, Valéria Cristina Sandrim, Rodrigo Ribeiro Resende

Clin Sci (Lond) (2017) 131 (23): 2813–2834.

DOI: https://doi.org/10.1042/CS20171398

Published: 28 November 2017

... 2017 microRNA resistant hypertension Signaling Pathways Resistant hypertension (RH) is characterized by a condition in which the patient requires four or more antihypertensive medications, including a diuretic, regardless of blood pressure (BP) control. RH patients can be classified...

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Articles

Circulating miR-200c is up-regulated in paediatric patients with familial hypercholesterolaemia and correlates with miR-33a/b levels: implication of a ZEB1-dependent mechanism

Marco D’Agostino, Francesco Martino, Sara Sileno, Francesco Barillà, Sara Beji, Lorenza Marchetti, Fabio Maria Gangi, Luca Persico, Mario Picozza, Anna Montali, Eliana Martino, Cristina Zanoni, Daniele Avitabile, Sandro Parrotto, Maurizio Colognesi Capogrossi, Alessandra Magenta

Clin Sci (Lond) (2017) 131 (18): 2397–2408.

DOI: https://doi.org/10.1042/CS20171121

Published: 08 September 2017

... Limited on behalf of the Biochemical Society 2017 cardiovascular disease hypercholesterolaemia microRNA miR-200c miR-33 oxidative stress paediatrics Zinc Finger E-box-Binding Homeobox 1 miRNAs are short, non-coding RNA molecules, that modulate the stability and/or the translational...

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Articles

Expression of miR-23a induces telomere shortening and is associated with poor clinical outcomes in patients with coronary artery disease

Mamoru Satoh, Takahito Nasu, Yuji Takahashi, Takuya Osaki, Sho Hitomi, Yoshihiro Morino, Motoyuki Nakamura

Clin Sci (Lond) (2017) 131 (15): 2007–2017.

DOI: https://doi.org/10.1042/CS20170242

Published: 13 July 2017

... ( satohm@iwate-med.ac.jp ) 24 03 2017 07 06 2017 23 06 2017 23 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere...

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Articles

MicroRNAs in the skin: role in development, homoeostasis and regeneration

Steven Horsburgh, Nicola Fullard, Mathilde Roger, Abbie Degnan, Stephen Todryk, Stefan Przyborski, Steven O’Reilly

Clin Sci (Lond) (2017) 131 (15): 1923–1940.

DOI: https://doi.org/10.1042/CS20170039

Published: 13 July 2017

..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their ability...

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Articles

Current epigenetic aspects the clinical kidney researcher should embrace

Anna Witasp, Amaryllis H. Van Craenenbroeck, Paul G. Shiels, Tomas J. Ekström, Peter Stenvinkel, Louise Nordfors

Clin Sci (Lond) (2017) 131 (14): 1649–1667.

DOI: https://doi.org/10.1042/CS20160596

Published: 30 June 2017

... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD...

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Articles

Novel potential targets for prevention of arterial restenosis: insights from the pre-clinical research

Amalia Forte, Barbara Rinaldi, Liberato Berrino, Francesco Rossi, Umberto Galderisi, Marilena Cipollaro

Clin Sci (Lond) (2014) 127 (11): 615–634.

DOI: https://doi.org/10.1042/CS20140131

Published: 25 July 2014

... proliferative disease. Although the main molecular and cellular mechanisms underlying restenosis have been well described, new signalling molecules and cell types controlling the progress of restenosis are continuously being discovered. In particular, microRNAs and vascular progenitor cells have recently been...

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Articles

In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts

Anke Nijhuis, Paolo Biancheri, Amy Lewis, Cleo L. Bishop, Paolo Giuffrida, Christopher Chan, Roger Feakins, Richard Poulsom, Antonio Di Sabatino, Gino Roberto Corazza, Thomas T. MacDonald, James O. Lindsay, Andrew R. Silver

Clin Sci (Lond) (2014) 127 (5): 341–350.

DOI: https://doi.org/10.1042/CS20140048

Published: 15 May 2014

... microRNA miR-29 stricture • Intestinal fibrosis and stricture formation is a frequent serious complication in CD. Understanding its aetiology is a significant unmet need, as current medical therapies are unable to reverse fibrosis, which remains the main indication for surgery...

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Articles

miR-296 /Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo

Federica Savi, Irene Forno, Alice Faversani, Andrea Luciani, Sarah Caldiera, Stefano Gatti, Paolo Foa, Dario Ricca, Gaetano Bulfamante, Valentina Vaira, Silvano Bosari

Clin Sci (Lond) (2014) 127 (4): 233–242.

DOI: https://doi.org/10.1042/CS20130580

Published: 10 April 2014

... in breast carcinogenesis and metastatic dissemination. Furthermore, an miR-296-5p -based therapeutic approach hampers breast cancer tumour growth in vivo . breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being a deeply...

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Articles

Circulating miRNA profiles provide a biomarker for severity of stroke outcomes associated with age and sex in a rat model

Amutha Selvamani, Madison H. Williams, Rajesh C. Miranda, Farida Sohrabji

Clin Sci (Lond) (2014) 127 (2): 77–89.

DOI: https://doi.org/10.1042/CS20130565

Published: 17 March 2014

...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex...

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Articles

microRNA profiles in coeliac patients distinguish different clinical phenotypes and are modulated by gliadin peptides in primary duodenal fibroblasts

Valentina Vaira, Leda Roncoroni, Donatella Barisani, Gabriella Gaudioso, Silvano Bosari, Gaetano Bulfamante, Luisa Doneda, Dario Conte, Carolina Tomba, Maria Teresa Bardella, Stefano Ferrero, Martina Locatelli, Luca Elli

Clin Sci (Lond) (2014) 126 (6): 417–423.

DOI: https://doi.org/10.1042/CS20130248

Published: 15 November 2013

..., which is characterized by an immunological reaction against gluten and transglutaminase in genetically predisposed subjects. However, the molecular determinants underpinning CD pathogenesis are yet to be fully elucidated and little data are available about the involvement of miRNAs (microRNAs) in CD...

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Articles

Molecular basis of cancer-therapy-induced cardiotoxicity: introducing microRNA biomarkers for early assessment of subclinical myocardial injury

Hardip Sandhu, Helen Maddock

Clin Sci (Lond) (2014) 126 (6): 377–400.

DOI: https://doi.org/10.1042/CS20120620

Published: 15 November 2013

... drugs. Correspondence: Dr Helen Maddock ( apx281@coventry.ac.uk ). 16 11 2012 22 8 2013 23 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biomarker cancer-therapy-induced cardiotoxicity early clinical assessment microRNA subclinical...

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Articles

Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectives

Amalia Forte, Marilena Cipollaro, Umberto Galderisi

Clin Sci (Lond) (2014) 126 (2): 123–138.

DOI: https://doi.org/10.1042/CS20130099

Published: 13 September 2013

... 2014 Biochemical Society 2014 endometriosis epigenetics epithelial progenitor cell mesenchymal stromal cell microRNA stem cell marker Human endometrium is the mucosal lining of the cavity of the uterus. It is composed of two layers: the outer is defined as “functionalis...

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Articles

microRNAs in cardiac development and regeneration

Enzo R. Porrello

Clin Sci (Lond) (2013) 125 (4): 151–166.

DOI: https://doi.org/10.1042/CS20130011

Published: 26 April 2013

...Enzo R. Porrello Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent...

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Articles

microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells

Pengfei Li, Wei Guo, Leilei Du, Junli Zhao, Yaping Wang, Liu Liu, Yali Hu, Yayi Hou

Clin Sci (Lond) (2013) 124 (1): 27–40.

DOI: https://doi.org/10.1042/CS20120121

Published: 07 September 2012

... study was performed to determine the function of miR-29b (microRNA-29b) in trophoblast cells and its underlying role in the pathogenesis of PE. The prediction of miR-29b target genes was performed using computer-based programs, including Targetscan, Pictar and miRBase. The function of these target genes...

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Articles

microRNAs in skeletal muscle differentiation and disease

Katarzyna Goljanek-Whysall, Dylan Sweetman, Andrea E. Münsterberg

Clin Sci (Lond) (2012) 123 (11): 611–625.

DOI: https://doi.org/10.1042/CS20110634

Published: 01 August 2012

...Katarzyna Goljanek-Whysall; Dylan Sweetman; Andrea E. Münsterberg miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed...

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Articles

The oncogenetic role of microRNA-31 as a potential biomarker in oesophageal squamous cell carcinoma

Tengfei Zhang, Qiming Wang, Dan Zhao, Yaling Cui, Bangrong Cao, Liping Guo, Shih Hsin Lu

Clin Sci (Lond) (2011) 121 (10): 437–447.

DOI: https://doi.org/10.1042/CS20110207

Published: 25 July 2011

...Tengfei Zhang; Qiming Wang; Dan Zhao; Yaling Cui; Bangrong Cao; Liping Guo; Shih Hsin Lu miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate the role of miR-31 in ESCC (oesophageal squamous cell carcinoma). We measured miR-31 in 45 paired...

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MicroRNA profiling in cancer

Reinhold Munker, George A. Calin

Clin Sci (Lond) (2011) 121 (4): 141–158.

DOI: https://doi.org/10.1042/CS20110005

Published: 20 April 2011

.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic...

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Articles

Serum microRNA characterization identifies miR - 885 - 5p as a potential marker for detecting liver pathologies

Junhao Gui, Yaping Tian, Xinyu Wen, Wenhui Zhang, Pengjun Zhang, Jing Gao, Wei Run, Liyuan Tian, Xingwang Jia, Yanhong Gao

Clin Sci (Lond) (2011) 120 (5): 183–193.

DOI: https://doi.org/10.1042/CS20100297

Published: 19 November 2010

...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...

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A translational study of circulating cell-free microRNA-1 in acute myocardial infarction

Yunhui Cheng, Ning Tan, Jian Yang, Xiaojun Liu, Xiaopei Cao, Pengcheng He, Xiaoli Dong, Shanshan Qin, Chunxiang Zhang

Clin Sci (Lond) (2010) 119 (2): 87–95.

DOI: https://doi.org/10.1042/CS20090645

Published: 20 April 2010

...Yunhui Cheng; Ning Tan; Jian Yang; Xiaojun Liu; Xiaopei Cao; Pengcheng He; Xiaoli Dong; Shanshan Qin; Chunxiang Zhang miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively...

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MicroRNAs: role in cardiovascular biology and disease

Chunxiang Zhang

Clin Sci (Lond) (2008) 114 (12): 699–706.

DOI: https://doi.org/10.1042/CS20070211

Published: 14 May 2008

...Chunxiang Zhang miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system...

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