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Keyword: microRNA
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Articles
Clin Sci (Lond) (2019) 133 (21): 2217-2220.
Published: 13 November 2019
... by Portland Press Limited on behalf of the Biochemical Society 2019 cardiovascular disease fibrosis microRNA Cardiovascular disease (CVD) is the leading cause of death worldwide, with over 17.6 million deaths per year [ 1 ]. Cardiomyopathy is a type of CVD and cardiac fibrosis is an...
Articles
Clin Sci (Lond) (2019) 133 (4): 583-595.
Published: 22 February 2019
...; Yuishin Izumi; Toshitaka Kawarai; Ryuji Kaji; Takeshi Kimura; Haruhisa Inoue; Koh Ono Recent reports, including ours, have indicated that microRNA (miR)-33 located within the intron of sterol regulatory element binding protein (SREBP) 2 controls cholesterol homeostasis and can be a potential therapeutic...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (1): 23-40.
Published: 03 January 2019
... bioactive compounds. Correspondence: Silvia Lorente-Cebrián ( slorente@unav.es ) 11 10 2018 29 11 2018 05 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 adipocytes exosomes MicroRNA metabolism non-coding RNAs...
Articles
Clin Sci (Lond) (2018) 132 (22): 2451-2467.
Published: 30 November 2018
... 2018 25 09 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 exosomes Insulin sensitivity microRNA pregnancy type 2 diabetes Maternal metabolism undergoes dynamic changes in pregnancy to ensure an adequate supply of...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2437-2449.
Published: 22 November 2018
...Jasmin Strutz; Silvija Cvitic; Hubert Hackl; Karl Kashofer; Hannah M. Appel; Andrea Thüringer; Gernot Desoye; Pieter Koolwijk; Ursula Hiden MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important, epigenetic regulators of endothelial function. Metabolic disturbances such as diabetes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (22): 2423-2436.
Published: 22 November 2018
... 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 atherosclerosis endothelial dysfunction inflammation microRNA Atherosclerosis and the presence of unstable plaques at carotid bifurcation is responsible for approximately 15...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2018) 132 (17): 1875-1888.
Published: 05 September 2018
... on behalf of the Biochemical Society 2018 atherosclerosis microRNA platelet adhesion and activation Platelets are discoid anuclear cells produced by megakaryocytes; while the bone marrow is the classical and most important site of proplatelet formation and platelet biogenesis [ 1...
Articles
Clin Sci (Lond) (2018) 132 (9): 925-942.
Published: 21 May 2018
.... Correspondence: Yvan Devaux ( yvan.devaux@lih.lu ) 05 02 2018 12 04 2018 16 04 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 biomarkers cardiovascular disease microRNA non-coding RNA physical exercise therapeutics...
Articles
Clin Sci (Lond) (2017) 131 (24): 2885-2900.
Published: 04 December 2017
...@enders.tch.harvard.edu ) 18 09 2017 01 11 2017 03 11 2017 03 11 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 adipocytes cardiac hypertrophy dyslipidemia high fat diet microRNA obesity The incidence of obesity has...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (23): 2813-2834.
Published: 28 November 2017
... 2017 microRNA resistant hypertension Signaling Pathways Resistant hypertension (RH) is characterized by a condition in which the patient requires four or more antihypertensive medications, including a diuretic, regardless of blood pressure (BP) control. RH patients can be classified...
Articles
Clin Sci (Lond) (2017) 131 (18): 2397-2408.
Published: 08 September 2017
... Limited on behalf of the Biochemical Society 2017 cardiovascular disease hypercholesterolaemia microRNA miR-200c miR-33 oxidative stress paediatrics Zinc Finger E-box-Binding Homeobox 1 miRNAs are short, non-coding RNA molecules, that modulate the stability and/or the translational...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2017) 131 (15): 2007-2017.
Published: 13 July 2017
... ( satohm@iwate-med.ac.jp ) 24 03 2017 07 06 2017 23 06 2017 23 06 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 Atherosclerosis cardiovascular events microRNA peripheral blood mononuclear cell statins telomere...
Articles
Clin Sci (Lond) (2017) 131 (15): 1923-1940.
Published: 13 July 2017
..., a tightly regulated network of molecular signals control development and regeneration, whether due to programmed cell termination or injury. MicroRNAs (miRs) are a relatively recent discovery; they are a class of small non-coding RNAs which possess a multitude of biological functions due to their...
Articles
Clin Sci (Lond) (2017) 131 (14): 1649-1667.
Published: 30 June 2017
... Stenvinkel ( peter.stenvinkel@ki.se ) 09 12 2016 17 04 2017 19 04 2017 © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2017 chronic kidney disease DNA methylation epigenetics microRNA Chronic kidney disease (CKD) is a...
Articles
Clin Sci (Lond) (2014) 127 (11): 615-634.
Published: 25 July 2014
... primarily proliferative disease. Although the main molecular and cellular mechanisms underlying restenosis have been well described, new signalling molecules and cell types controlling the progress of restenosis are continuously being discovered. In particular, microRNAs and vascular progenitor cells have...
Articles
Clin Sci (Lond) (2014) 127 (5): 341-350.
Published: 15 May 2014
... fibrosis microRNA miR-29 stricture • Intestinal fibrosis and stricture formation is a frequent serious complication in CD. Understanding its aetiology is a significant unmet need, as current medical therapies are unable to reverse fibrosis, which remains the main indication for surgery...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (4): 233-242.
Published: 10 April 2014
... a role in breast carcinogenesis and metastatic dissemination. Furthermore, an miR-296-5p -based therapeutic approach hampers breast cancer tumour growth in vivo . breast carcinoma microRNA neoplasm metastasis and recurrence prognosis Scribble • Despite breast cancer being a...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 127 (2): 77-89.
Published: 17 March 2014
...Amutha Selvamani; Madison H. Williams; Rajesh C. Miranda; Farida Sohrabji Small non-coding RNA [miRNA (microRNA)] found in the circulation have been used successfully as biomarkers and mechanistic targets for chronic and acute disease. The present study investigated the impact of age and sex on...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2014) 126 (6): 417-423.
Published: 15 November 2013
..., which is characterized by an immunological reaction against gluten and transglutaminase in genetically predisposed subjects. However, the molecular determinants underpinning CD pathogenesis are yet to be fully elucidated and little data are available about the involvement of miRNAs (microRNAs) in CD. In...
Articles
Clin Sci (Lond) (2014) 126 (6): 377-400.
Published: 15 November 2013
... drugs. Correspondence: Dr Helen Maddock ( apx281@coventry.ac.uk ). 16 11 2012 22 8 2013 23 8 2013 © The Authors Journal compilation © 2014 Biochemical Society 2014 biomarker cancer-therapy-induced cardiotoxicity early clinical assessment microRNA subclinical...
Articles
Clin Sci (Lond) (2014) 126 (2): 123-138.
Published: 13 September 2013
... Journal compilation © 2014 Biochemical Society 2014 endometriosis epigenetics epithelial progenitor cell mesenchymal stromal cell microRNA stem cell marker Human endometrium is the mucosal lining of the cavity of the uterus. It is composed of two layers: the outer is defined as...
Articles
Clin Sci (Lond) (2013) 125 (4): 151-166.
Published: 26 April 2013
...Enzo R. Porrello Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent...
Articles
Clin Sci (Lond) (2013) 124 (1): 27-40.
Published: 07 September 2012
... study was performed to determine the function of miR-29b (microRNA-29b) in trophoblast cells and its underlying role in the pathogenesis of PE. The prediction of miR-29b target genes was performed using computer-based programs, including Targetscan, Pictar and miRBase. The function of these target genes...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2012) 123 (11): 611-625.
Published: 01 August 2012
...Katarzyna Goljanek-Whysall; Dylan Sweetman; Andrea E. Münsterberg miRNAs (microRNAs) are novel post-transcriptional regulators of gene expression. Several miRNAs, expressed exclusively in muscle, play important roles during muscle development, growth and regeneration; other ubiquitously expressed...
Articles
Clin Sci (Lond) (2011) 121 (10): 437-447.
Published: 25 July 2011
...Tengfei Zhang; Qiming Wang; Dan Zhao; Yaling Cui; Bangrong Cao; Liping Guo; Shih Hsin Lu miR-31 (microRNA-31) is frequently altered in numerous cancers. The aim of the present study was to investigate the role of miR-31 in ESCC (oesophageal squamous cell carcinoma). We measured miR-31 in 45 paired...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2011) 121 (4): 141-158.
Published: 20 April 2011
.... Gene expression profiling based on mRNA has led to further refinement of the classification and diagnosis of cancer. More recently, miRNAs (microRNAs), among other small non-coding RNA molecules, have been discovered and found to be major players in cell biology. miRNAs, having both oncogenic and...
Articles
Clin Sci (Lond) (2011) 120 (5): 183-193.
Published: 19 November 2010
...Junhao Gui; Yaping Tian; Xinyu Wen; Wenhui Zhang; Pengjun Zhang; Jing Gao; Wei Run; Liyuan Tian; Xingwang Jia; Yanhong Gao Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate the feasibility of using...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2010) 119 (2): 87-95.
Published: 20 April 2010
...Yunhui Cheng; Ning Tan; Jian Yang; Xiaojun Liu; Xiaopei Cao; Pengcheng He; Xiaoli Dong; Shanshan Qin; Chunxiang Zhang miRNAs (microRNAs) participate in many diseases including cardiovascular disease. In contrast with our original hypothesis, miRNAs exist in circulating blood and are relatively...
Articles
Clin Sci (Lond) (2008) 114 (12): 699-706.
Published: 14 May 2008
...Chunxiang Zhang miRNAs (microRNAs) comprise a novel class of endogenous, small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have demonstrated that miRNAs are highly expressed in the cardiovascular system...