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Articles

Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity

Uwe Querfeld, Robert H. Mak, Axel Radlach Pries

Clin Sci (Lond) (2020) 134 (12): 1333–1356.

https://doi.org/10.1042/CS20200279

Published: 16 June 2020

... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...

View articletitled, Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity

Articles

Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity

Markos Klonizakis, Ahmad Alkhatib, Geoff Middleton, Mark F. Smith

Clin Sci (Lond) (2013) 124 (9): 579–587.

https://doi.org/10.1042/CS20120412

Published: 21 January 2013

... the multi-dimensional effects that such interventions may bring. That is to say the number of trials studying the microcirculation involving both exercise and diet control has been limited and restricted to specific patient groups, i.e. diabetics [ 20 ]. Even in those where the effects on endothelial...

View articletitled, Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity

Articles

Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

Kuei-Chuan Lee, Ying-Ying Yang, Yi-Tsau Huang, Fa-Yauh Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee

Clin Sci (Lond) (2010) 119 (1): 45–55.

https://doi.org/10.1042/CS20090601

Published: 07 April 2010

... for 1 week on the hepatic microcirculation of cirrhotic rats. Cirrhosis was induced by bile duct ligation with sham-operated rats serving as normal controls. Intrahepatic resistance was evaluated by in situ liver perfusion. Expression of phospho-eNOS (endothelial NO synthase), iNOS (inducible...

View articletitled, Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

Articles

End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation

Christopher J. Lockhart, Paul K. Hamilton, Cathy E. Quinn, Gary E. McVeigh

Clin Sci (Lond) (2009) 116 (3): 175–190.

https://doi.org/10.1042/CS20080069

Published: 08 January 2009

...Christopher J. Lockhart; Paul K. Hamilton; Cathy E. Quinn; Gary E. McVeigh Risk factors for cardiovascular disease mediate their effects by altering the structure and function of wall and endothelial components of arterial blood vessels. A pathological change in the microcirculation plays a pivotal...

View articletitled, End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation

Articles

Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol–blood pressure relationship

Renate T. de Jongh, Richard G. Ijzerman, Erik H. Serné, Mirjam M. van Weissenbruch, Jasper J. Voordouw, Henriette A. Delemarre-van de Waal, Coen D. A. Stehouwer

Clin Sci (Lond) (2007) 113 (2): 83–91.

https://doi.org/10.1042/CS20060357

Published: 13 June 2007

... microcirculation To our knowledge, data on the association of cortisol with microvascular function have hitherto been limited. Previous studies in isolated cells and vessels have shown that corticosteroids impair angiogenesis [ 22 – 24 ] and that corticosteroids are able to disrupt microvascular...

View articletitled, Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol–blood pressure relationship

Articles

Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Yves Harder, Michaela Amon, Mirko Georgi, Claudia Scheuer, Rene Schramm, Martin Rücker, Brigitte Pittet, Dominique Erni, Michael D. Menger

Clin Sci (Lond) (2007) 112 (8): 429–440.

https://doi.org/10.1042/CS20060187

Published: 13 March 2007

...) ischaemic tolerance microcirculation necrosis pedicled skin flap Delivery of oxygen is the most decisive factor in determining necrosis or survival of ischaemic tissue. Hence the principal function of the microcirculation is the supply of the tissue with oxygen. In plastic and reconstructive...

View articletitled, Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Articles

Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase

Ismail H. Mallick, Marc C. Winslet, Alexander M. Seifalian

Clin Sci (Lond) (2006) 111 (6): 373–380.

https://doi.org/10.1042/CS20060119

Published: 14 November 2006

.... In the present study, we have investigated the effects of PDTC on the intestinal microcirculation following IR (ischaemia/reperfusion) injury of the intestine. Male Sprague–Dawley rats ( n =72) were randomly assigned to four groups ( n =18/group): (i) sham-operated group, who underwent laparotomy without...

View articletitled, Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase

Articles

TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance

Richard G. Ijzerman, Jasper J. Voordouw, Mirjam M. Van Weissenbruch, John S. Yudkin, Erik H. Serné, Henriette A. Delemarre-Van De Waal, Coen D. A. Stehouwer

Clin Sci (Lond) (2006) 110 (3): 361–368.

https://doi.org/10.1042/CS20050314

Published: 10 February 2006

... mass index capillary recruitment microcirculation insulin resistance tumour necrosis factor (TNF) Therefore elevated levels of TNF-α may be associated with impaired microvascular function in humans, which may decrease the delivery of glucose and insulin to skeletal muscle, and play a role...

View articletitled, TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance

Articles

N -Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis

Giuseppe Fusai, George K. Glantzounis, Tarek Hafez, Wenxuan Yang, Alberto Quaglia, Hemant Sheth, Sanjeev Kanoria, Harry Parkes, Alexander Seifalian, Brian R. Davidson

Clin Sci (Lond) (2005) 109 (5): 465–473.

https://doi.org/10.1042/CS20050081

Published: 24 October 2005

... significantly improved portal flow, hepatic microcirculation, bile composition and bile flow after 5 h of reperfusion. NAC administration was also associated with less hepatocellular injury, as indicated by ALT serum activity, and decreased the oxidation of DHR to RH. In conclusion, NAC administration decreased...

View articletitled, N -Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis

Articles

Effect of hypothermia and HTK on the microcirculation in the rat cremaster muscle after ischaemia

Jacqueline BASTIAANSE, Dick W. SLAAF, Mirjam G. A. oude EGBRINK, Gary L. ANDERSON, Hans VINK, Brigitte E. P. A. van der HEIJDEN, Moshe KON

Clin Sci (Lond) (2005) 109 (1): 117–123.

https://doi.org/10.1042/CS20040154

Published: 23 June 2005

... were killed by intracardial injection of an overdose of sodium pentobarbital (Nembutal™; Sanofi Sante). 2 6 2004 1 12 2004 21 12 2004 21 12 2004 The Biochemical Society 2005 hypothermia ischaemia/reperfusion microcirculation muscle perfusion preservation solution...

View articletitled, Effect of hypothermia and HTK on the microcirculation in the rat cremaster muscle after ischaemia

Articles

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study

Qing LU, Ingemar BJÖRKHEM, Bengt WRETLIND, Ulf DICZFALUSY, Peter HENRIKSSON, Anna FREYSCHUSS

Clin Sci (Lond) (2005) 108 (6): 507–513.

https://doi.org/10.1042/CS20040291

Published: 24 May 2005

... of variation between different days was <13% when the mean of at least two TtP assessments on each occasion was used [ 19 ]. Correspondence: Dr Anna Freyschuss (email [email protected] ). ascorbic acid microcirculation oxidative stress Type II diabetes vascular disease...

View articletitled, Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study

Articles

Effects of age and physical fitness on microcirculatory function

Ferdinando FRANZONI, Fabio GALETTA, Carmela MORIZZO, Valter LUBRANO, Carlo PALOMBO, Gino SANTORO, Eleuterio FERRANNINI, Alfredo QUIÑONES-GALVAN

Clin Sci (Lond) (2004) 106 (3): 329–335.

https://doi.org/10.1042/CS20030229

Published: 01 March 2004

... by increasing NO availability. Correspondence: Dr Fabio Galetta (e-mail [email protected] ). 9 7 2003 3 10 2003 30 10 2003 30 10 2003 © 2004 The Biochemical Society 2004 aging exercise endothelial function microcirculation nitric oxide (NO) Clinical Science...

View articletitled, Effects of age and physical fitness on microcirculatory function

Articles

Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure

Faisel KHAN, Gwen KENNEDY, Vance A. SPENCE, David J. NEWTON, Jill J. F. BELCH

Clin Sci (Lond) (2004) 106 (2): 183–189.

https://doi.org/10.1042/CS20030246

Published: 01 February 2004

... cholinergic function chronic fatigue syndrome Gulf War syndrome microcirculation laser Doppler imaging organophosphate Clinical Science (2004) 106, 183 189 (Printed in Great Britain) 183 Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness...

View articletitled, Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure

Articles

Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects

P. COATS

Clin Sci (Lond) (2003) 105 (6): 683–689.

https://doi.org/10.1042/CS20030203

Published: 01 December 2003

.... Correspondence: Dr Paul Coats (e-mail [email protected] ). 11 6 2003 23 7 2003 23 7 2003 © 2003 The Biochemical Society 2003 blood pressure microcirculation regional blood flow remodelling Clinical Science (2003) 105, 683 689 (Printed in Great Britain) 683 Myogenic...

View articletitled, Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects

Articles

Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity

Malgorzata MILKIEWICZ, Olga HUDLICKA, Julie VERHAEG, Stuart EGGINTON, Margaret D. BROWN

Clin Sci (Lond) (2003) 105 (4): 473–482.

https://doi.org/10.1042/CS20030035

Published: 01 October 2003

...-mail [email protected] ). 27 1 2003 12 5 2003 2 6 2003 2 6 2003 © 2003 The Biochemical Society 2003 angiogenesis endothelial receptors ischaemia microcirculation vascular endothelial growth factor (VEGF) Clinical Science (2003) 105, 473 482 (Printed in Great Britain...

View articletitled, Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity

Articles

Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study

N. ANIM-NYAME, J. GAMBLE, S.R. SOORANNA, M.R. JOHNSON, M.H. SULLIVAN, P.J. STEER

Clin Sci (Lond) (2003) 104 (4): 405–412.

https://doi.org/10.1042/cs1040405

Published: 20 March 2003

..., and that it is related to alterations in endothelial cell and neutrophil activation. Correspondence: Dr N. Anim-Nyame (e-mail [email protected] ). 14 11 2002 29 1 2003 The Biochemical Society and the Medical Research Society © 2003 2003 isovolumetric venous pressure microcirculation...

View articletitled, Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study

Articles

Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm

H.M. Omar FAROUQUE, Ian T. MEREDITH

Clin Sci (Lond) (2003) 104 (1): 39–46.

https://doi.org/10.1042/cs1040039

Published: 16 December 2002

... channels microcirculation regional blood flow vasoconstriction/dilation 39Clinical Science (2003) 104, 39 46 (Printed in Great Britain) Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm H. M. Omar FAROUQUE and Ian T. MEREDITH Cardiovascular...

View articletitled, Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm

Articles

Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

Andrew D. H. CLARK, Eugene J. BARRETT, Stephen RATTIGAN, Michelle G. WALLIS, Michael G. CLARK

Clin Sci (Lond) (2001) 100 (3): 283–290.

https://doi.org/10.1042/cs1000283

Published: 30 January 2001

... 2000 12 9 2000 14 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 adrenaline blood flow capillaries insulin glucose uptake laser Doppler flow microcirculation muscle oxygen uptake skeletal muscle 283Clinical Science (2001) 100, 283 290...

View articletitled, Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

Articles

Vitamin C modifies the cardiovascular and microvascular responses to cigarette smoke inhalation in man

J. GAMBLE, P. S. GREWAL, I. B. GARTSIDE

Clin Sci (Lond) (2000) 98 (4): 455–460.

https://doi.org/10.1042/cs0980455

Published: 21 March 2000

... Sweetcroft Lane, Hillingdon, Middlesex UB10 9LD, U.K. (e-mail [email protected] ). 7 12 1999 21 1 2000 31 1 2000 The Biochemical Society and the Medical Research Society © 2000 2000 isovolumetric venous congestion pressure heart rate microcirculation strain gauge...

View articletitled, Vitamin C modifies the cardiovascular and microvascular responses to cigarette smoke inhalation in man

Articles

Assessment of the Microcirculation in Cardiovascular Disease

H. A. J. Struijker-Boudier, F. R. L. Crijns, J. Stolte, H. Van Essen

Clin Sci (Lond) (1996) 91 (2): 131–139.

https://doi.org/10.1042/cs0910131

Published: 01 August 1996

...H. A. J. Struijker-Boudier; F. R. L. Crijns; J. Stolte; H. Van Essen © 1996 The Biochemical Society and the Medical Research Society 1996 capillaroscopy diabetes hypertension intravital microscopy microcirculation Clinical Science (1996) 91, 131-139 (Printed i n Great Britain...

View articletitled, Assessment of the Microcirculation in Cardiovascular Disease

Articles

Autonomic Control of Skin Microvessels: Assessment by Power Spectrum of Photoplethysmographic Waves

Luciano Bernardi, Alberto Radaelli, Pier Luigi Solda, Andrew J. S. Coats, Martin Reeder, Alessandro Calciati, Christopher S. Garrard, Peter Sleight

Clin Sci (Lond) (1996) 90 (5): 345–355.

https://doi.org/10.1042/cs0900345

Published: 01 May 1996

... changes remains uncertain. 2. In 10 healthy males and in 15 patients in intensive care, we assessed the origin of the autonomic influences on spontaneous fluctuations in the microcirculation of the skin, obtained by an infra-red photoplethysmographic device; we used spectral analysis techniques to compare...

View articletitled, Autonomic Control of Skin Microvessels: Assessment by Power Spectrum of Photoplethysmographic Waves

Articles

Pathophysiology of Microvascular Disease in Non-Insulin-Dependent Diabetes

Alan J. Jaap, John E. Tooke

Clin Sci (Lond) (1995) 89 (1): 3–12.

https://doi.org/10.1042/cs0890003

Published: 01 July 1995

... prevalence of hypertension, large- vessel complications and foot ulceration and, in contrast to patients with insulin-dependent (type 1) diabetes mellitus (IDDM), may already have signifi- cant large- and small-vessel disease at the time of diagnosis. Damage to the microcirculation plays a central role...

View articletitled, Pathophysiology of Microvascular Disease in Non-Insulin-Dependent Diabetes

Articles

Peripheral Microvascular Function in Human Heart Failure

Ian R. Mahy, John E. Tooke

Clin Sci (Lond) (1995) 88 (5): 501–508.

https://doi.org/10.1042/cs0880501

Published: 01 May 1995

...Ian R. Mahy; John E. Tooke © 1995 The Biochemical Society and the Medical Research Society 1995 autoregulation capillary endothelium haemodynamics heart failure microcirculation oedema Clinical Science (1995) 88, 501-508 (Printed in Great Britain) 50 I Editorial Review Peripheral...

View articletitled, Peripheral Microvascular Function in Human Heart Failure

Articles

Vascular Control of Inflammatory Oedema

John B. Warren

Clin Sci (Lond) (1993) 84 (6): 581–584.

https://doi.org/10.1042/cs0840581

Published: 01 June 1993

...John B. Warren © 1993 The Biochemical Society and the Medical Research Society 1993 cyclic AMP endothelium inflammation microcirculation nitric oxide oedema permeability vasodilatation Clinical Science (1993) 84, 581-584 (Printed in Great Britain) Editorial Review 581 Vascular...

View articletitled, Vascular Control of Inflammatory Oedema

Articles

Lack of effect of peripheral nervous blockade on nocturnal fluctuations in lower-leg subcutaneous blood flow in man

J. H. Sindrup, L. J. Petersen, J. Kastrup, H. Wroblewski, J. K. Kristensen

Clin Sci (Lond) (1993) 84 (3): 297–304.

https://doi.org/10.1042/cs0840297

Published: 01 March 1993

... factors cannot be excluded. The possible physiological significance of the nocturnal hyperaemia is discussed. adipose tissue blood flow central nervous factors isotope-wash-out technique local nervous blockade lower leg microcirculation nocturnal fluctuations subcutaneous blood flow...

View articletitled, Lack of effect of peripheral nervous blockade on nocturnal fluctuations in lower-leg subcutaneous blood flow in man

Articles

Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide

T. K. Rogers, A. G. Stewart, A. H. Morice

Clin Sci (Lond) (1992) 83 (6): 723–729.

https://doi.org/10.1042/cs0830723

Published: 01 December 1992

... Research Society 1992 anoxia atrial natriuretic peptide chronic hypoxia microcirculation prostaglandin F 2α pulmonary artery pulmonary circulation small-vessel myography vasoconstrictor vasodilator Clinical Science (1992) 83, 723-729 (Printed in Great Britain) Effect of chronic hypoxia...

View articletitled, Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide

Articles

Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men

J. H. Sindrup, H. Wroblewski, J. Kastrup, F. Biering-Sørensen

Clin Sci (Lond) (1992) 82 (1): 47–54.

https://doi.org/10.1042/cs0820047

Published: 01 January 1992

... microcirculation nocturnal fluctuations paraplegia spinal cord injury subcutaneous blood flow rate thermoregulation 133 Xe-washout technique Clinical Science (1992) 82, 47-54 (Printed in Great Britain) I 47 Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men J. H. SINDRUP*, H...

View articletitled, Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men

Articles

Capillary Hypertension and Abnormal Pressure Dynamics in Patients with Essential Hypertension

S. A. Williams, M. Boolell, G. A. MacGregor, L. H. Smaje, S. M. Wasserman, J. E. Tooke

Clin Sci (Lond) (1990) 79 (1): 5–8.

https://doi.org/10.1042/cs0790005

Published: 01 July 1990

...) in the resistance equation in essential hypertension. Key words: blood-pressure micropuncture, capillary, hypertension, microcirculation. INTRODUCTION An elevation of capillary blood pressure has been put forward as an explanation for several experimental Correspondence: Dr S. A. Williams, Early Clinical Research...

View articletitled, Capillary Hypertension and Abnormal Pressure Dynamics in Patients with Essential Hypertension

Articles

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

J. Kastrup, T. Nørgaard, H.-H. Parving, N. A. Lassen

Clin Sci (Lond) (1987) 72 (1): 123–130.

https://doi.org/10.1042/cs0720123

Published: 01 January 1987

... vascular resistance, thereby impeding hyperaemic responses. 23 6 1986 12 8 1986 © 1970 The Biochemical Society and the Medical Research Society 1970 cutaneous blood flow diabetic microangiopathy microcirculation type 1 diabetes vascular distensibility vascular resistance...

View articletitled, Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

Articles

The Influence of a Combined Oral Contraceptive Pill and Menstrual Cycle Phase on Digital Microvascular Haemodynamics

J. E. Tooke, H. Tindall, G. P. McNicol

Clin Sci (Lond) (1981) 61 (1): 91–95.

https://doi.org/10.1042/cs0610091

Published: 01 July 1981

... are interpreted as evidence for a powerful modulating influence of sex steroids on digital microvascular haemodynamics. 3 2 1981 3 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 capillary pressure microcirculation oral contraception ClinicalScience (1981...

View articletitled, The Influence of a Combined Oral Contraceptive Pill and Menstrual Cycle Phase on Digital Microvascular Haemodynamics

Articles

Effect of Streptozotocin-Diabetes on the Local and General Responses to Injury in the Rat

E. A. Elebute, R. A. Little

Clin Sci Mol Med (1978) 54 (4): 431–437.

https://doi.org/10.1042/cs0540431

Published: 01 April 1978

... concentration was higher than that predicted from the relationship between these variables in the uninjured rat. 22 10 1976 22 11 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 diabetes mellitus microcirculation oedema shock traumatic streptozotocin...

View articletitled, Effect of Streptozotocin-Diabetes on the Local and General Responses to Injury in the Rat

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