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Keywords: microcirculation
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Articles

Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity

Uwe Querfeld, Robert H. Mak, Axel Radlach Pries
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (12): 1333–1356.
https://doi.org/10.1042/CS20200279
Published: 16 June 2020
... to progressive organ damage. Most of the vast endothelial surface area is part of the microcirculation, but most research in CKD-related cardiovascular disease (CVD) has been devoted to macrovascular complications. We have reviewed all publications evaluating structure and function of the microcirculation...
View article titled, Microvascular disease in chronic kidney disease: the base of the iceberg in cardiovascular comorbidity
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Articles

Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity

Markos Klonizakis, Ahmad Alkhatib, Geoff Middleton, Mark F. Smith
Journal: Clinical Science
Clin Sci (Lond) (2013) 124 (9): 579–587.
https://doi.org/10.1042/CS20120412
Published: 21 January 2013
... for the experimental arm; DinamapDash 2500; GE Healthcare) were recorded throughout the protocol. There were no adverse effects. aging cardio-pulmonary exercise testing endothelium microcirculation nutrition ventilatory threshold • Age-dependent vascular endothelial dysfunction and reduced...
View article titled, Mediterranean diet- and exercise-induced improvement in age-dependent vascular activity
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Articles

Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability

Kuei-Chuan Lee, Ying-Ying Yang, Yi-Tsau Huang, Fa-Yauh Lee, Ming-Chih Hou, Han-Chieh Lin, Shou-Dong Lee
Journal: Clinical Science
Clin Sci (Lond) (2010) 119 (1): 45–55.
https://doi.org/10.1042/CS20090601
Published: 07 April 2010
... for 1 week on the hepatic microcirculation of cirrhotic rats. Cirrhosis was induced by bile duct ligation with sham-operated rats serving as normal controls. Intrahepatic resistance was evaluated by in situ liver perfusion. Expression of phospho-eNOS (endothelial NO synthase), iNOS (inducible...
View article titled, Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability
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Articles

End-organ dysfunction and cardiovascular outcomes: the role of the microcirculation

Christopher J. Lockhart, Paul K. Hamilton, Cathy E. Quinn, Gary E. McVeigh
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (3): 175–190.
https://doi.org/10.1042/CS20080069
Published: 08 January 2009
...Christopher J. Lockhart; Paul K. Hamilton; Cathy E. Quinn; Gary E. McVeigh Risk factors for cardiovascular disease mediate their effects by altering the structure and function of wall and endothelial components of arterial blood vessels. A pathological change in the microcirculation plays a pivotal...
View article titled, End-organ dysfunction and cardiovascular outcomes: the role of the <span class="search-highlight">microcirculation</span>
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Articles

Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol–blood pressure relationship

Renate T. de Jongh, Richard G. Ijzerman, Erik H. Serné, Mirjam M. van Weissenbruch, Jasper J. Voordouw, Henriette A. Delemarre-van de Waal, Coen D. A. Stehouwer
Journal: Clinical Science
Clin Sci (Lond) (2007) 113 (2): 83–91.
https://doi.org/10.1042/CS20060357
Published: 13 June 2007
... 2 2007 13 2 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 blood pressure capillary glucocorticoid hypertension insulin resistance microcirculation Cortisol excess is characterized by a cluster of cardiovascular risk factors consisting...
View article titled, Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol–blood pressure relationship
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Articles

Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance

Yves Harder, Michaela Amon, Mirko Georgi, Claudia Scheuer, Rene Schramm, Martin Rücker, Brigitte Pittet, Dominique Erni, Michael D. Menger
Journal: Clinical Science
Clin Sci (Lond) (2007) 112 (8): 429–440.
https://doi.org/10.1042/CS20060187
Published: 13 March 2007
... protein-32 (HSP-32) ischaemic tolerance microcirculation necrosis pedicled skin flap Delivery of oxygen is the most decisive factor in determining necrosis or survival of ischaemic tissue. Hence the principal function of the microcirculation is the supply of the tissue with oxygen. In plastic...
View article titled, Aging is associated with an increased susceptibility to ischaemic necrosis due to microvascular perfusion failure but not a reduction in ischaemic tolerance
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Articles

Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase

Ismail H. Mallick, Marc C. Winslet, Alexander M. Seifalian
Journal: Clinical Science
Clin Sci (Lond) (2006) 111 (6): 373–380.
https://doi.org/10.1042/CS20060119
Published: 14 November 2006
.... In the present study, we have investigated the effects of PDTC on the intestinal microcirculation following IR (ischaemia/reperfusion) injury of the intestine. Male Sprague–Dawley rats ( n =72) were randomly assigned to four groups ( n =18/group): (i) sham-operated group, who underwent laparotomy without...
View article titled, Pyrrolidine dithiocarbamate protects the small bowel from warm ischaemia/reperfusion injury of the intestine: the role of haem oxygenase
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Articles

TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance

Richard G. Ijzerman, Jasper J. Voordouw, Mirjam M. Van Weissenbruch, John S. Yudkin, Erik H. Serné, Henriette A. Delemarre-Van De Waal, Coen D. A. Stehouwer
Journal: Clinical Science
Clin Sci (Lond) (2006) 110 (3): 361–368.
https://doi.org/10.1042/CS20050314
Published: 10 February 2006
... that these relationships are initiated during growth from childhood to adulthood. body mass index capillary recruitment microcirculation insulin resistance tumour necrosis factor (TNF) 1 Both authors contributed equally to this study. Correspondence: Professor Coen D. A. Stehouwer (email csteh...
View article titled, TNF-α levels are associated with skin capillary recruitment in humans: a potential explanation for the relationship between TNF-α and insulin resistance
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Articles

N -Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis

Giuseppe Fusai, George K. Glantzounis, Tarek Hafez, Wenxuan Yang, Alberto Quaglia, Hemant Sheth, Sanjeev Kanoria, Harry Parkes, Alexander Seifalian, Brian R. Davidson
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (5): 465–473.
https://doi.org/10.1042/CS20050081
Published: 24 October 2005
... significantly improved portal flow, hepatic microcirculation, bile composition and bile flow after 5 h of reperfusion. NAC administration was also associated with less hepatocellular injury, as indicated by ALT serum activity, and decreased the oxidation of DHR to RH. In conclusion, NAC administration decreased...
View article titled, N -Acetylcysteine ameliorates the late phase of liver ischaemia/reperfusion injury in the rabbit with hepatic steatosis
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Articles

Effect of hypothermia and HTK on the microcirculation in the rat cremaster muscle after ischaemia

Jacqueline BASTIAANSE, Dick W. SLAAF, Mirjam G. A. oude EGBRINK, Gary L. ANDERSON, Hans VINK, Brigitte E. P. A. van der HEIJDEN, Moshe KON
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (1): 117–123.
https://doi.org/10.1042/CS20040154
Published: 23 June 2005
... were killed by intracardial injection of an overdose of sodium pentobarbital (Nembutal™; Sanofi Sante). 2 6 2004 1 12 2004 21 12 2004 21 12 2004 The Biochemical Society 2005 hypothermia ischaemia/reperfusion microcirculation muscle perfusion preservation solution...
View article titled, Effect of hypothermia and HTK on the <span class="search-highlight">microcirculation</span> in the rat cremaster muscle after ischaemia
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Articles

Effect of ascorbic acid on microcirculation in patients with Type II diabetes: a randomized placebo-controlled cross-over study

Qing LU, Ingemar BJÖRKHEM, Bengt WRETLIND, Ulf DICZFALUSY, Peter HENRIKSSON, Anna FREYSCHUSS
Journal: Clinical Science
Clin Sci (Lond) (2005) 108 (6): 507–513.
https://doi.org/10.1042/CS20040291
Published: 24 May 2005
... knowledge, the effects of ascorbic acid treatment on the microcirculation at the level of individual capillaries have not been reported previously. Correspondence: Dr Anna Freyschuss (email anna.freyschuss@medhs.ki.se ). 5 10 2004 14 1 2005 27 1 2005 27 1 2005...
View article titled, Effect of ascorbic acid on <span class="search-highlight">microcirculation</span> in patients with Type II diabetes: a randomized placebo-controlled cross-over study
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Articles

Effects of age and physical fitness on microcirculatory function

Ferdinando FRANZONI, Fabio GALETTA, Carmela MORIZZO, Valter LUBRANO, Carlo PALOMBO, Gino SANTORO, Eleuterio FERRANNINI, Alfredo QUIÑONES-GALVAN
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (3): 329–335.
https://doi.org/10.1042/CS20030229
Published: 01 March 2004
... by increasing NO availability. Correspondence: Dr Fabio Galetta (e-mail fgaletta@med.unipi.it ). 9 7 2003 3 10 2003 30 10 2003 30 10 2003 © 2004 The Biochemical Society 2004 aging exercise endothelial function microcirculation nitric oxide (NO) Clinical Science...
View article titled, Effects of age and physical fitness on microcirculatory function
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Articles

Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure

Faisel KHAN, Gwen KENNEDY, Vance A. SPENCE, David J. NEWTON, Jill J. F. BELCH
Journal: Clinical Science
Clin Sci (Lond) (2004) 106 (2): 183–189.
https://doi.org/10.1042/CS20030246
Published: 01 February 2004
... cholinergic function chronic fatigue syndrome Gulf War syndrome microcirculation laser Doppler imaging organophosphate Clinical Science (2004) 106, 183 189 (Printed in Great Britain) 183 Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness...
View article titled, Peripheral cholinergic function in humans with chronic fatigue syndrome, Gulf War syndrome and with illness following organophosphate exposure
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Articles

Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects

P. COATS
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (6): 683–689.
https://doi.org/10.1042/CS20030203
Published: 01 December 2003
.... 11 6 2003 23 7 2003 23 7 2003 © 2003 The Biochemical Society 2003 Correspondence: Dr Paul Coats (e-mail paul.coats@strath.ac.uk ). blood pressure microcirculation regional blood flow remodelling Clinical Science (2003) 105, 683 689 (Printed in Great Britain) 683...
View article titled, Myogenic, mechanical and structural characteristics of resistance arterioles from healthy and ischaemic subjects
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Articles

Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity

Malgorzata MILKIEWICZ, Olga HUDLICKA, Julie VERHAEG, Stuart EGGINTON, Margaret D. BROWN
Journal: Clinical Science
Clin Sci (Lond) (2003) 105 (4): 473–482.
https://doi.org/10.1042/CS20030035
Published: 01 October 2003
...-mail M.Milkiewicz@bham.ac.uk ). 27 1 2003 12 5 2003 2 6 2003 2 6 2003 © 2003 The Biochemical Society 2003 angiogenesis endothelial receptors ischaemia microcirculation vascular endothelial growth factor (VEGF) Clinical Science (2003) 105, 473 482 (Printed in Great Britain...
View article titled, Differential expression of Flk-1 and Flt-1 in rat skeletal muscle in response to chronic ischaemia: favourable effect of muscle activity
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Articles

Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study

N. ANIM-NYAME, J. GAMBLE, S.R. SOORANNA, M.R. JOHNSON, M.H. SULLIVAN, P.J. STEER
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (4): 405–412.
https://doi.org/10.1042/cs1040405
Published: 20 March 2003
..., and that it is related to alterations in endothelial cell and neutrophil activation. Correspondence: Dr N. Anim-Nyame (e-mail n.anim@ic.ac.uk ). 14 11 2002 29 1 2003 The Biochemical Society and the Medical Research Society © 2003 2003 isovolumetric venous pressure microcirculation...
View article titled, Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study
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Articles

Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm

H.M. Omar FAROUQUE, Ian T. MEREDITH
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (1): 39–46.
https://doi.org/10.1042/cs1040039
Published: 16 December 2002
... channels microcirculation regional blood flow vasoconstriction/dilation 39Clinical Science (2003) 104, 39 46 (Printed in Great Britain) Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm H. M. Omar FAROUQUE and Ian T. MEREDITH Cardiovascular...
View article titled, Effects of inhibition of ATP-sensitive potassium channels on metabolic vasodilation in the human forearm
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Articles

Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment

Andrew D. H. CLARK, Eugene J. BARRETT, Stephen RATTIGAN, Michelle G. WALLIS, Michael G. CLARK
Journal: Clinical Science
Clin Sci (Lond) (2001) 100 (3): 283–290.
https://doi.org/10.1042/cs1000283
Published: 30 January 2001
... 2000 12 9 2000 14 11 2000 The Biochemical Society and the Medical Research Society © 2001 2001 adrenaline blood flow capillaries insulin glucose uptake laser Doppler flow microcirculation muscle oxygen uptake skeletal muscle 283Clinical Science (2001) 100, 283 290...
View article titled, Insulin stimulates laser Doppler signal by rat muscle in vivo, consistent with nutritive flow recruitment
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Articles

Vitamin C modifies the cardiovascular and microvascular responses to cigarette smoke inhalation in man

J. GAMBLE, P. S. GREWAL, I. B. GARTSIDE
Journal: Clinical Science
Clin Sci (Lond) (2000) 98 (4): 455–460.
https://doi.org/10.1042/cs0980455
Published: 21 March 2000
... Sweetcroft Lane, Hillingdon, Middlesex UB10 9LD, U.K. (e-mail john.gamble@virgin.net ). 7 12 1999 21 1 2000 31 1 2000 The Biochemical Society and the Medical Research Society © 2000 2000 isovolumetric venous congestion pressure heart rate microcirculation strain gauge...
View article titled, Vitamin C modifies the cardiovascular and microvascular responses to cigarette smoke inhalation in man
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Articles

Assessment of the Microcirculation in Cardiovascular Disease

H. A. J. Struijker-Boudier, F. R. L. Crijns, J. Stolte, H. Van Essen
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (2): 131–139.
https://doi.org/10.1042/cs0910131
Published: 01 August 1996
...H. A. J. Struijker-Boudier; F. R. L. Crijns; J. Stolte; H. Van Essen © 1996 The Biochemical Society and the Medical Research Society 1996 capillaroscopy diabetes hypertension intravital microscopy microcirculation Clinical Science (1996) 91, 131-139 (Printed i n Great Britain...
View article titled, Assessment of the <span class="search-highlight">Microcirculation</span> in Cardiovascular Disease
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Articles

Autonomic Control of Skin Microvessels: Assessment by Power Spectrum of Photoplethysmographic Waves

Luciano Bernardi, Alberto Radaelli, Pier Luigi Solda, Andrew J. S. Coats, Martin Reeder, Alessandro Calciati, Christopher S. Garrard, Peter Sleight
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (5): 345–355.
https://doi.org/10.1042/cs0900345
Published: 01 May 1996
... changes remains uncertain. 2. In 10 healthy males and in 15 patients in intensive care, we assessed the origin of the autonomic influences on spontaneous fluctuations in the microcirculation of the skin, obtained by an infra-red photoplethysmographic device; we used spectral analysis techniques to compare...
View article titled, Autonomic Control of Skin Microvessels: Assessment by Power Spectrum of Photoplethysmographic Waves
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Articles

Pathophysiology of Microvascular Disease in Non-Insulin-Dependent Diabetes

Alan J. Jaap, John E. Tooke
Journal: Clinical Science
Clin Sci (Lond) (1995) 89 (1): 3–12.
https://doi.org/10.1042/cs0890003
Published: 01 July 1995
... prevalence of hypertension, large- vessel complications and foot ulceration and, in contrast to patients with insulin-dependent (type 1) diabetes mellitus (IDDM), may already have signifi- cant large- and small-vessel disease at the time of diagnosis. Damage to the microcirculation plays a central role...
View article titled, Pathophysiology of Microvascular Disease in Non-Insulin-Dependent Diabetes
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Articles

Peripheral Microvascular Function in Human Heart Failure

Ian R. Mahy, John E. Tooke
Journal: Clinical Science
Clin Sci (Lond) (1995) 88 (5): 501–508.
https://doi.org/10.1042/cs0880501
Published: 01 May 1995
... takes place at the level of the microcirculation, the hallmark of an adequate circulation is the ability to maintain microvascular haemodynamics which allow optimum provision of substrate for metabolic needs and prevent accumulation of unwanted or toxic metabolites, while simultaneously preserving...
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Articles

Vascular Control of Inflammatory Oedema

John B. Warren
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (6): 581–584.
https://doi.org/10.1042/cs0840581
Published: 01 June 1993
...John B. Warren © 1993 The Biochemical Society and the Medical Research Society 1993 cyclic AMP endothelium inflammation microcirculation nitric oxide oedema permeability vasodilatation Clinical Science (1993) 84, 581-584 (Printed in Great Britain) Editorial Review 581 Vascular...
View article titled, Vascular Control of Inflammatory Oedema
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Articles

Lack of effect of peripheral nervous blockade on nocturnal fluctuations in lower-leg subcutaneous blood flow in man

J. H. Sindrup, L. J. Petersen, J. Kastrup, H. Wroblewski, J. K. Kristensen
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (3): 297–304.
https://doi.org/10.1042/cs0840297
Published: 01 March 1993
... factors cannot be excluded. The possible physiological significance of the nocturnal hyperaemia is discussed. adipose tissue blood flow central nervous factors isotope-wash-out technique local nervous blockade lower leg microcirculation nocturnal fluctuations subcutaneous blood flow...
View article titled, Lack of effect of peripheral nervous blockade on nocturnal fluctuations in lower-leg subcutaneous blood flow in man
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Articles

Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide

T. K. Rogers, A. G. Stewart, A. H. Morice
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (6): 723–729.
https://doi.org/10.1042/cs0830723
Published: 01 December 1992
... Research Society 1992 anoxia atrial natriuretic peptide chronic hypoxia microcirculation prostaglandin F 2α pulmonary artery pulmonary circulation small-vessel myography vasoconstrictor vasodilator Clinical Science (1992) 83, 723-729 (Printed in Great Britain) Effect of chronic hypoxia...
View article titled, Effect of chronic hypoxia on rat pulmonary resistance vessels: vasodilatation by atrial natriuretic peptide
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Articles

Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men

J. H. Sindrup, H. Wroblewski, J. Kastrup, F. Biering-Sørensen
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (1): 47–54.
https://doi.org/10.1042/cs0820047
Published: 01 January 1992
... microcirculation nocturnal fluctuations paraplegia spinal cord injury subcutaneous blood flow rate thermoregulation 133 Xe-washout technique Clinical Science (1992) 82, 47-54 (Printed in Great Britain) I 47 Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men J. H. SINDRUP*, H...
View article titled, Nocturnal variations in lower-leg subcutaneous blood flow in paraplegic men
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Articles

Capillary Hypertension and Abnormal Pressure Dynamics in Patients with Essential Hypertension

S. A. Williams, M. Boolell, G. A. MacGregor, L. H. Smaje, S. M. Wasserman, J. E. Tooke
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (1): 5–8.
https://doi.org/10.1042/cs0790005
Published: 01 July 1990
...) in the resistance equation in essential hypertension. Key words: blood-pressure micropuncture, capillary, hypertension, microcirculation. INTRODUCTION An elevation of capillary blood pressure has been put forward as an explanation for several experimental Correspondence: Dr S. A. Williams, Early Clinical Research...
View article titled, Capillary Hypertension and Abnormal Pressure Dynamics in Patients with Essential Hypertension
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Articles

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

J. Kastrup, T. Nørgaard, H.-H. Parving, N. A. Lassen
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (1): 123–130.
https://doi.org/10.1042/cs0720123
Published: 01 January 1987
... vascular resistance, thereby impeding hyperaemic responses. © 1970 The Biochemical Society and the Medical Research Society 1970 cutaneous blood flow diabetic microangiopathy microcirculation type 1 diabetes vascular distensibility vascular resistance 23 6 1986 12 8 1986...
View article titled, Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy
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Articles

The Influence of a Combined Oral Contraceptive Pill and Menstrual Cycle Phase on Digital Microvascular Haemodynamics

J. E. Tooke, H. Tindall, G. P. McNicol
Journal: Clinical Science
Clin Sci (Lond) (1981) 61 (1): 91–95.
https://doi.org/10.1042/cs0610091
Published: 01 July 1981
... are interpreted as evidence for a powerful modulating influence of sex steroids on digital microvascular haemodynamics. 3 2 1981 3 3 1981 © 1981 The Biochemical Society and the Medical Research Society 1981 capillary pressure microcirculation oral contraception ClinicalScience (1981...
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Articles

Effect of Streptozotocin-Diabetes on the Local and General Responses to Injury in the Rat

E. A. Elebute, R. A. Little
Journal: Clinical Science
Clin Sci Mol Med (1978) 54 (4): 431–437.
https://doi.org/10.1042/cs0540431
Published: 01 April 1978
... concentration was higher than that predicted from the relationship between these variables in the uninjured rat. 22 10 1976 22 11 1977 © 1978 The Biochemical Society and the Medical Research Society 1978 diabetes mellitus microcirculation oedema shock traumatic streptozotocin...
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