...Peter Wilson; James Morgan; John W. Funder; Peter J. Fuller; Morag J. Young Coronary, vascular and perivascular inflammation in rats following MR (mineralocorticoid receptor) activation plus salt are well-characterized precursors for the appearance of cardiac fibrosis. Endogenous corticosterone...

...Andrew M. WILSON; Erika J. SIMS; Allan D. STRUTHERS; Brian J. LIPWORTH 1. As mineralocorticoid and adrenocorticoid activity are both under the diurnal control of adrenocorticotropic hormone secretion, we aimed to evaluate whether the normal circadian rhythm of cortisol and aldosterone secretion...

.... after liquorice ingestion) results in cortisol acting as a potent mineralocorticoid. We have evaluated the effect of the synthetic liquorice derivative, carbenoxolone, on this enzyme complex. 2. Carbenoxolone given to six volunteers in metabolic balance produced sodium retention with suppression...

...Anne-Marie Moura; Manuel Worcel 1. Aldosterone given acutely to male Wistar rats stimulated ouabain-sensitive and ouabain-insensitive 22 Na efflux from tail arteries. 2. These effects of aldosterone seem to depend on the activation of specific mineralocorticoid receptors, as they are blocked...

... to mineralocorticoid excess. Patients with aldosterone-producing adenoma ( n = 14) were followed for 6 weeks during the recurrence of hypertension after spironolactone treatment had been stopped. Patients with adrenal insufficiency ( n = 4) were followed for 6–9 weeks after treatment with dexamethasone (1 mg daily...

... renin activity rose as a result of spironolactone administration (200 mg three times a day for 5 days). 5. If renal dopamine has a role in mineralocorticoid ‘escape’ then it may be permissive only. The mechanisms of control of dopamine production could include tubular sodium concentration, tubular...

...S. P. Wilkinson; I. K. Smith; Helen Moodie; Lucilla Poston; R. Williams 1. The mineralocorticoid 9α-fluorohydrocortisone was given to 12 patients with cirrhosis without ascites. In seven an ‘escape’ from its sodium-retaining effects was observed, the other five continuing to retain sodium. 2...

... postulated to underlie this resistance. Since a mineralocorticoid etiology for adrenal-regeneration hypertension has been postulated and all mineralocorticoids are thought to act on common receptors, these previous reports are difficult to reconcile. 2. To determine if an absolute or relative resistance...

.... This enhanced response to aldosterone required the presence of the adrenal glands during the induction period, could be suppressed by a high sodium intake, but could not be induced by a low sodium diet. 3. No difference between high K + and control rats could be detected in renal mineralocorticoid receptors...

...J. D. Baxter; M. Schambelan; D. T. Matulich; B. J. Spindler; F. C. Bartter 1. A competitive ‘mineralocorticoid’ receptor-binding technique has been used to study plasma ‘mineralocorticoid’ activity in normal and hypertensive states. The binding reaction mixture contains the competitor steroids...

...A. M. Khokhar; J. D. H. Slater; T. P. Jowett; N. N. Payne 1. Suppression of the renin—aldosterone system by expansion of the extracellular fluid volume with extra sodium and mineralocorticoid for 6 days was studied in nine young men with very mild essential hypertension and in ten normotensive...

... and diminished by salt restriction or spironolactone. 4. Angiotensin-salt hypertension is reversed by transplants of compatible renal medulla subcutaneously. © 1994 The Biochemical Society and the Medical Research Society 1994 angiotensin-salt hypertension mineralocorticoid renal medulla salt...