...R. G. Jacomb; F. J. Brunnberg 1. One hundred patients with severe essential hypertension have been treated with minoxidil for a mean period of 8·4 months in a study involving eleven European centres. Seventy-two males and twenty-eight females were included in the group; the mean age was 55 years...

...G. Dunea; B. Mamdani; S. D. Mahurkar 1. Twenty patients with severe or moderate hypertension were treated with minoxidil for 284 patient-months. 2. The blood pressure was controlled in all patients, including those refractory to maximal doses of conventional anti-hypertensive agents. 3. In patients...

...D. Hall; K. L. Froer; C. Loracher 1. The chronic administration of minoxidil, 0024–0·212 mmol (5–40 mg) daily, to fifty-two severely hypertensive patients resulted in an average reduction of mean arterial pressure from 170 to 111 mmHg. 2. Haemodynamic studies in twelve of these patients indicated...

...H. Ærenlund Jensen; K. Rasmussen; N. Mosbæk 1. We have evaluated the effectiveness and safety of minoxidil in moderately hypertensive out-patients. Eight patients were treated with hydrochlorothiazide and minoxidil for 5 months. The only female patient developed slight, reversible facial hair...

...G. Connor; R. L. Wilburn; C. M. Bennett 1. Thirty moderately severely hypertensive patients were studied in a double-blind comparison of minoxidil and hydrallazine in combination with frusemide and propranolol. 2. Blood pressure control in both groups of patients was satisfactory but long-term...

...K. O'Malley; J. L. McNay 1. Twelve patients with essential hypertension were treated aggressively with minoxidil in order to achieve blood pressure control as rapidly as possible. 2. After an initial dose of 5 mg, dose increments were administered 6 hourly until a fall in blood pressure...

...W. B. Martin; G. R. Zins; W. A. Freyburger 1. Minoxidil, an experimental arteriolar dilator, has been used in conjunction with a diuretic and a sympathetic nervous system suppressant in 510 patients with refractory hypertension, of whom 323 remain on treatment. The results in two of a total...

...Charles A. Chidsey 1. Minoxidil is a direct-acting vasodilator which has been used in combination with propranolol and hydrochlorothiazide to lower blood pressure in hypertensive patients. 2. The therapeutic efficacy of minoxidil was compared with that of hydrallazine used in the same combination...