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Keywords: mitochondrial function
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Articles
Clin Sci (Lond) (2021) 135 (7): 979–990.
Published: 16 April 2021
... in skeletal muscle cells and increased after exercise training. Then, IGF2 deficiency in myotubes from C2C12 and primary skeletal muscle cells (PMSCs) led to impaired mitochondrial function, reduced mitochondria-related protein content, and decreased mitochondrial biogenesis. Furthermore, we explored...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2019) 133 (24): 2431–2447.
Published: 16 December 2019
... diet (ND) fed groups. After feeding with either ND or HFD for 12 weeks, rats in each dietary group were divided into groups to receive either the vehicle, Mdivi1 (1.2 mg/kg, i.p.), M1 (2 mg/kg, i.p.) or combined treatment for 14 days. The cardiac function, cardiac mitochondrial function, metabolic and...
Articles
Clin Sci (Lond) (2018) 132 (19): 2103–2115.
Published: 02 October 2018
... difference among groups was observed regarding oxidative stress markers. HbSS mice displayed a higher intramuscular acidosis during the ischemic period while their mitochondrial function was impaired as compared with their HbAA and HbAS counterparts. These metabolic abnormalities could worsen the...
Articles
Clin Sci (Lond) (2016) 130 (18): 1641–1653.
Published: 08 August 2016
.... Considering the close association between oxidative stress and autophagy [ 13 ] and the powerful antioxidative property of PD, we hypothesized that PD treatment during reperfusion would attenuate I/R injury by enhancing autophagy. apoptosis autophagy ischaemia/reperfusion mitochondrial function...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2016) 130 (11): 931–941.
Published: 29 April 2016
... appears to mediate this metabolic switch. gestational diabetes mammalian target of rapamycin (mTOR) miR-143 mitochondrial function placenta • Placental efficiency is reduced in women with A2GDM compared with BMI-matched A1GDM and non-diabetic controls. A2GDM placentae show...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2015) 129 (7): 589–599.
Published: 14 July 2015
...Joaquin Perez-Schindler; Andrew Philp Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and type 2 diabetes. Mitochondria display substantial plasticity in...
Articles
Clin Sci (Lond) (2014) 127 (12): 655–663.
Published: 08 August 2014
... by lipid deposition within the liver [intrahepatocellular lipid (IHCL)], is associated with insulin resistance and the metabolic syndrome (MS). It has been suggested that impaired skeletal muscle mitochondrial function may contribute to ectopic lipid deposition, and the associated MS, by altering...
Articles
Clin Sci (Lond) (2010) 119 (7): 293–301.
Published: 25 June 2010
... concurrently. Statin intake may blunt mitochondrial function and the adaptive response to exercise training. Thus combining exercise training with statin administration may have adverse effects. We examined whether improvements in cardiometabolic risk factors, insulin sensitivity and mitochondrial function...
Includes: Supplementary data
Articles
Clin Sci (Lond) (2006) 111 (2): 135–143.
Published: 13 July 2006
... 13 CO 2 for ketoisocaproate at 60 min was associated with the highest prediction (positive predictive value, 0.90; negative predictive value, 0.73) for NASH, yielding an overall sensitivity of 68% and specificity of 94%. In conclusion, both microsomal and mitochondrial functions are disturbed in NASH...
Articles
Clin Sci (Lond) (1987) 73 (6): 593–599.
Published: 01 December 1987
... and cardiac adenosine triphosphatase activities or renal cortical mitochondrial function. 4. The adenosine triphosphate content of kidney cortex and cardiac mitochondrial function were significantly depressed in CBDL rats. 5. The results demonstrate that jaundice in CBDL rats is associated with...