... and metabolic health (e.g., improved glucose tolerance and insulin sensitivity). By contrast, silencing Fundc1 or Pgc1α reversed the changes induced by silencing FoxO1, which impaired mitochondrial quality control and function. Ablation of Atg7 suppressed mitochondrial turnover and function, causing metabolic...

... cardiomyopathy mitochondrial dysfunction mitochondrial quality control mitophagy redox In summary, mitophagy and mitochondrial biogenesis are coordinately regulated and tightly coupled. Mitophagy can eliminate damaged mitochondria, which in turn stimulates mitochondrial biogenesis to replenish...