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Keywords: mitophagy
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Clin Sci (Lond) (2024) 138 (6): 371–385.
Published: 12 March 2024
... are regulated during adipose browning. In the present study, we found that mice lacking adipocyte FoxO1, a transcription factor that regulates autophagy, adopted an alternate mechanism of mitophagy to maintain mitochondrial turnover and quality control during adipose browning. Post-developmental deletion...
Includes: Supplementary data
Clin Sci (Lond) (2022) 136 (10): 733–746.
Published: 24 May 2022
... to cigarette smoke may activate autophagy, resulting in ciliary dysfunction and death of airway epithelial cells, whereas in stable COPD most studies have demonstrated an impairment in autophagy, with reduced autophagic flux and accumulation of abnormal mitochondria (defective mitophagy) and linked to cellular...
Clin Sci (Lond) (2020) 134 (12): 1491–1519.
Published: 25 June 2020
... authorship. 24 04 2020 01 06 2020 03 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD...
Clin Sci (Lond) (2016) 130 (17): 1511–1521.
Published: 18 July 2016
... design of effective strategies to delay or treat DCM. Mitochondrial dysfunction is recognized as the driving force for the pathogenesis of DCM; therefore, maintaining cardiac mitochondrial quality is crucial for DCM prevention. Mitophagy is the process by which cells degrade abnormal or superfluous...
Clin Sci (Lond) (2016) 130 (15): 1285–1305.
Published: 29 June 2016
... cardiovascular disease diet epigenetic modification histones chromatin mitochondrial fusion–fission mitophagy Aerobic metabolism constitutes the energetic foundation of the great majority of living systems on Earth. By processing oxygen to harness the essential redox and phosphorylation energy...