... are regulated during adipose browning. In the present study, we found that mice lacking adipocyte FoxO1, a transcription factor that regulates autophagy, adopted an alternate mechanism of mitophagy to maintain mitochondrial turnover and quality control during adipose browning. Post-developmental deletion...

...Ming Yang; Qin Zhang; Shilu Luo; Yachun Han; Hao Zhao; Na Jiang; Yan Liu; Li Li; Chenrui Li; Chongbin Liu; Liyu He; Xuejing Zhu; Yu Liu; Lin Sun Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development...

... to cigarette smoke may activate autophagy, resulting in ciliary dysfunction and death of airway epithelial cells, whereas in stable COPD most studies have demonstrated an impairment in autophagy, with reduced autophagic flux and accumulation of abnormal mitochondria (defective mitophagy) and linked to cellular...

... 2020 01 06 2020 03 06 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 arterial stiffness endothelial function mitophagy oxidative stress reactive oxygen species Cardiovascular diseases (CVD) remain the largest...

... design of effective strategies to delay or treat DCM. Mitochondrial dysfunction is recognized as the driving force for the pathogenesis of DCM; therefore, maintaining cardiac mitochondrial quality is crucial for DCM prevention. Mitophagy is the process by which cells degrade abnormal or superfluous...

... (components, e.g. enzymes, carriers, transporters, DNA) and (iv) dynamical (spatio-temporal dynamics, e.g. fission–fusion, respiration, mitophagy, oscillations). Various mitochondrial network functions emerge from a dynamic interplay between all these aspects. For example, the predominance of fission over...