..., microbially trained macrophages produce more monocyte chemoattractant protein-1 (MCP-1)—a chemokine that is fundamental to the recruitment of circulating monocytes to developing plaques. Vaccination with BCG accelerated atherosclerosis in rabbits fed a cholesterol-rich Western-type diet (WD) [ 21 ]; however...

...Jong-Shyan Wang; Ya-Lun Chang; Yi-Ching Chen; Hsing-Hua Tsai; Tieh-Cheng Fu Exercise and hypoxia paradoxically modulate vascular thrombotic risks. The shedding of procoagulant-rich microparticles from monocytes may accelerate the pathogenesis of atherothrombosis. The present study explores...

... protein kinase, has emerged as an important regulator of chronic inflammation. However, the relationship between mTOR and NF-κB remains poorly defined. The aim of the present study was to investigate the role of mTOR in the pro-inflammatory pathway of human monocytes (HMCs) in patients with coronary...

..., an eNOS (endothelial NO synthase)-dependent endothelial response. However, since not all children manifest endothelial dysfunction, we hypothesized that differences in circulating monocyte subsets and NO production may underlie the vascular phenotype in paediatric OSA. Matched pre-pubertal children...

... in atherosclerosis. Monocytes, which comprise part of the innate immune system, can be recruited to inflamed endothelium and this recruitment has been shown to be proportional to the extent of atherosclerotic disease. Monocytes undergo migration into the vasculature, they differentiate into macrophage phenotypes...

... vasodilator peptide and inhibits proliferation and migration of vascular smooth muscle cells. In this study, we investigated the production and secretion of ADM by monocytes and macrophages by Northern blot analysis, RIA and immunocytochemistry. Northern blot analysis showed that ADM mRNA was expressed...

... that would distinguish SIRS patients with systemic inflammation from patients without inflammation. The study included 100 acutely ill patients with SIRS. Peripheral blood neutrophil and monocyte CD11b expression, serum interleukin-6, interleukin-1β, tumour necrosis factor-α and C-reactive protein were...

...C. I. Westacott; J. T. Whicher; C. W. Hutton; P. A. Dieppe 1. Increased spontaneous production of interleukin-1, measured as lymphocyte-activating factor activity, was seen in unstimulated monocytes from systemic sclerosis patients. 2. Inhibitory activity to interleukin-1 was seen in both normal...

... abnormal results, suggesting that the test procedure may be of value as a screening procedure for this disease. 5 5 1975 © 1975 The Biochemical Society and the Medical Research Society 1975 chronic granulomatous disease leucocyte monocyte phagocyte neutrophil Nitroblue Tetrazolium...