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Keywords: monocytes
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Clin Sci (Lond) (2018) 132 (5): 609–613.
Published: 15 March 2018
... (LT), and/or death. From a pathogenic point of view, exhaustion of drug metabolizing pathways, cell death mechanisms, activation of local immune cells, such as Kupffer cells, and recruitment of inflammatory leukocytes including monocytes and lymphocytes are key drivers of DILI progression. Taking...
Clin Sci (Lond) (2016) 130 (14): 1237–1246.
Published: 13 June 2016
...-associated inflammation. This study aims to assess in acute coronary syndrome (ACS) patients (1) inflammasome activation in circulating monocytes and (2) whether short-term oral colchicine, a recognized anti-inflammatory agent that has been shown to be cardio-protective in clinical studies, might acutely...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (13): 1089–1104.
Published: 23 May 2016
... for this is unclear. Large platelets are hyperactive and associated with adverse clinical outcomes. We determined mean platelet volume (MPV) and platelet–monocyte conjugation (PMC) using blood samples from patients, and blood and the spleen from mice with AMI. We further measured changes in platelet size, PMC...
Clin Sci (Lond) (2015) 129 (12): 1151–1161.
Published: 30 October 2015
..., the mechanism by which lipids regulate NR4A1 expression remains unknown. We aimed to elucidate the underlying mechanism of NR4A1 expression in monocytes during hypercholesterolaemia, and reveal the potential role of NR4A1 in hypercholesterolaemia-induced circulating inflammation. Circulating leucocytes were...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (4): 319–330.
Published: 21 May 2015
... monocytes (Mo) play an essential role in the host immune response to chronic infections. We previously demonstrated that CD16 pos Mo were expanded in TB (tuberculosis) patients, correlated with disease severity and were refractory to dendritic cell differentiation. In the present study, we investigated...
Includes: Supplementary data
Clin Sci (Lond) (2015) 129 (3): 235–244.
Published: 08 May 2015
... gastrointestinal infections that are Shiga toxin (Stx) producing. Monocytes contribute to HUS evolution by producing cytokines that sensitize endothelial cells to Stx action and migration to the injured kidney. As CC chemokine receptors (CCRs) are involved in monocyte recruitment to injured tissue, we analysed...
Clin Sci (Lond) (2015) 129 (1): 27–38.
Published: 01 April 2015
... from patients with AMI than from patients with SA. Increased fetuin-B expression in serum from AMI patients was also confirmed by Western blot analysis. Treatment with recombinant human fetuin-B increased the migration in monocytes and macrophages in a concentration-dependent manner. Fetuin-B also...
Includes: Supplementary data
Clin Sci (Lond) (2002) 102 (3): 315–320.
Published: 13 February 2002
... stimulation monocytes outcome septic shock tumour necrosis factor-. 315Clinical Science (2002) 102, 315 320 (Printed in Great Britain) Response of tumour necrosis factor-a to delayed in vitro monocyte stimulation in patients with septic shock is related to outcome Olivier APPOLONI*, Jean-Louis VINCENT...
Clin Sci (Lond) (2001) 101 (6): 731–738.
Published: 21 November 2001
... the adhesion of monocytes to endothelial cells, a key early event in atherosclerosis. We investigated the adhesion of primary human monocytes (isolated by elutriation) to human umbilical vein endothelial cell cultures after incubation with endothelin-1 (0.1 and 0.01nM; approximately physiological...
Clin Sci (Lond) (1999) 97 (5): 529–538.
Published: 15 September 1999
...), soluble E-selectin and C-reactive protein, and neutrophil and monocyte CD11b expression] and routine blood cell counts in 20 patients with systemic inflammatory response syndrome and positive blood culture. Eight patients with shock due to community-acquired infection developed OF, whereas 11 normotensive...
Clin Sci (Lond) (1999) 97 (4): 475–483.
Published: 01 September 1999
... to parity. There were no differences in a number of other biochemical markers of pre-eclampsia, including plasma albumin, uric acid, triacylglycerol, and total, low-density lipoprotein and high-density lipoprotein cholesterol. Basophil, monocyte and lymphocyte counts were elevated before delivery...
Clin Sci (Lond) (1999) 97 (1): 59–65.
Published: 21 May 1999
..., but not glutamine, was able to counteract the DEX effect on TNFα secretion. Glutamine, arginine and OKG supplementation increased H 2 O 2 production by monocytes and polymorphonuclear neutrophils from DEX-treated rats. All DEX-treated rats showed plasma and muscle glutamine depletion and also a decrease...
Clin Sci (Lond) (1998) 96 (1): 89–97.
Published: 01 January 1999
...Colin MURPHY; Philip NEWSHOLME Macrophages and monocytes are cells with a large capacity for cytokine production. Cytokines produced by these cells are not preformed and released upon stimulation, but must be transcribed and translated. Although much is known concerning the regulation of the latter...
Clin Sci (Lond) (1998) 95 (4): 397–407.
Published: 01 October 1998
... and human monocytes are capable of utilizing glutamine at high rates, contain sufficient activity of the enzymes required to convert glutamine to citrulline (and subsequently citrulline to arginine) to account for observed rates of nitrite synthesis in the absence of extracellular l -arginine...
Clin Sci (Lond) (1994) 87 (2): 179–186.
Published: 01 August 1994
... probes corresponding to cDNA sequences common to mouse macrophage inducible NO synthase and rat vascular smooth inducible NO synthase. Monocytes and macrophages were identified by immunohistochemistry with the mouse monoclonal antibody ED1. 2. After lipopolysaccharide alone, the major site of NO synthase...
Clin Sci (Lond) (1994) 86 (5): 505–510.
Published: 01 May 1994
... by the various subtypes of leucocytes. 2. We have compared the exercise-induced leucocytosis in six splenectomized and six intact subjects. The blood concentrations of leucocytes as well as of most subtypes, except monocytes and eosinophilic granulocytes, increased substantially at the end of a 5 min exercise...
Clin Sci (Lond) (1990) 78 (2): 133–137.
Published: 01 February 1990
...M. N. Aparicio-Pagés; G. den Hartog; H. W. Verspaget; A. S. Peña; J. W. M. van der Meer; R. van Furth; C. B. H. W. Lamers 1. Natural killer cell activity and monocyte cytotoxicity was evaluated in three subgroups of patients with primary hypogammaglobulinaemia (ten patients with late-onset, eight...
Clin Sci (Lond) (1984) 67 (1): 139–142.
Published: 01 July 1984
...Roy Taylor; Steven J. Proctor; Oliver James; Frederick Clark; K. George M. M. Alberti 1. The assumption that insulin binding to monocytes reflects that of insulin binding to adipocytes has been examined. 2. In normal, diabetic, thyrotoxic and cirrhotic subjects no correlation was observed between...
Clin Sci (Lond) (1980) 58 (4): 295–300.
Published: 01 April 1980
...A. S. Mee; D. P. Jewell 1. The activity of a specific lysosomal marker enzyme N '-acetyl-β-d-glucosaminidase has been determined fluorimetrically in the monocytes and in the serum of patients with Crohn's disease and ulcerative colitis and compared with results obtained from healthy and disease...