... the effect of this polymorphism on B 1 -receptor-mediated coronary artery dilation and peripheral blood mononuclear cell activation. Vasorelaxant responses of human coronary microarteries from subjects without coronary disease to des-Arg 9 -bradykinin and to bradykinin were studied in organ bath experiments...

... mononuclear cell Congestive heart failure is a leading cause of death in industrialized nations. In the U.S. alone, over 500000 new cases are diagnosed yearly [ 1 ]. The mainstay of treatment is lifestyle modification and pharmacotherapy, including treatment with β-blockers and ACE inhibitors...

..., mononuclear cells and neutrophils in broncho-alveolar lavage fluid 4h after injection. Bosentan and Ro 46-8443 (at doses of 30 and 10mg·kg -1 respectively) inhibited the neutrophil infiltration induced by oleic acid by approx. 80%. None of the antagonists modified control (basal) pulmonary microvascular...