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Keywords: monophosphoryl lipid A
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Ryan J. Stark, Hyehun Choi, Stephen R. Koch, Benjamin A. Fensterheim, Fred S. Lamb, Edward R. Sherwood
Journal:
Clinical Science
Clin Sci (Lond) (2016) 130 (6): 451–461.
Published: 04 February 2016
... clinical benefit. The adjuvant monophosphoryl lipid A (MPLA) is a weak toll-like receptor 4 (TLR4) agonist that induces negligible inflammation but retains potent immunomodulatory properties. We postulated that pre-treatment with MPLA would inhibit the inflammatory response of endothelial cells...
Includes: Supplementary data