.... Correspondence: Teresinha Leal ( [email protected] ) 26 9 2016 13 2 2017 14 2 2017 14 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 CFTR cystic fibrosis inflammation macrophages mouse model...

... understood. To investigate the postnatal role of VSMCs (vascular smooth muscle cells) EGFR in vivo and ex vivo , we generated a mouse model with cell-specific and inducible deletion of VSMC EGFR and studied the effect on basal blood pressure, acute pressure response to, among others, Ang II in vivo as well...

... aortic plaque accumulation and necrotic core formation within the relevant BM-transplanted chimaeras. atherosclerosis bone marrow transplantation diabetes mellitus mouse model receptor for advanced glycation end-products (RAGE) • Increased RAGE activation has been implicated...

... of aseptic loosening. Mouse models have been essential in the progress made in the early comprehension of pathophysiology and in testing new therapeutic agents for particle-induced osteolysis. However, despite this encouraging progress, there is still no valid clinical alternative to revision surgery...

... and the caveolae-compartmentalized signalling have any role in AAA development has never been investigated. abdominal aortic aneurysm caveolae hypertension mouse model signalling mechanism vascular smooth muscle AngII was purchased from Sigma–Aldrich and Bachem. BAPN was purchased from TCI...

...) challenge of HDM-sensitized and challenged mice were insensitive to oral prednisone therapy. In summary we have described a CS-resistant mouse model mimicking the key aspects of viral asthma exacerbation using the clinically relevant aeroallergen HDM and the viral mimic poly(I:C). This model may provide...

... in an HDM (house dust mite) mouse model of asthma and assess the effect of oral corticosteroids. HDM alone significantly increased eosinophils, lymphocytes, neutrophils, macrophages and a number of cytokines in BAL (bronchoalveolar lavage), all of which were sensitive to treatment with prednisolone...

... glomerular basement membrane filtration barrier mouse model podocyte slit diaphragm Podocytes are highly differentiated epithelial cells that contribute to the size-selective nature of the glomerular filtration barrier (reviewed in [ 1 ]). Major processes extend from the cell body and branch out...