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Keywords: mouse model
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Clin Sci (Lond) (2017) 131 (11): 1107–1121.
Published: 17 May 2017
.... Correspondence: Teresinha Leal ( teresinha.leal@uclouvain.be ) 26 9 2016 13 2 2017 14 2 2017 14 2 2017 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 CFTR cystic fibrosis inflammation macrophages mouse model...
Includes: Supplementary data
Clin Sci (Lond) (2016) 130 (1): 19–33.
Published: 30 November 2015
... understood. To investigate the postnatal role of VSMCs (vascular smooth muscle cells) EGFR in vivo and ex vivo , we generated a mouse model with cell-specific and inducible deletion of VSMC EGFR and studied the effect on basal blood pressure, acute pressure response to, among others, Ang II in vivo as well...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (7): 485–497.
Published: 17 June 2014
... aortic plaque accumulation and necrotic core formation within the relevant BM-transplanted chimaeras. atherosclerosis bone marrow transplantation diabetes mellitus mouse model receptor for advanced glycation end-products (RAGE) • Increased RAGE activation has been implicated...
Includes: Supplementary data
Clin Sci (Lond) (2014) 127 (5): 277–293.
Published: 07 May 2014
... of aseptic loosening. Mouse models have been essential in the progress made in the early comprehension of pathophysiology and in testing new therapeutic agents for particle-induced osteolysis. However, despite this encouraging progress, there is still no valid clinical alternative to revision surgery...
Clin Sci (Lond) (2014) 126 (11): 785–800.
Published: 13 February 2014
... of ADAM17 activation and subsequent oxidative stress. Caveolin 1 may provide a novel therapeutic target for prevention of abdominal aortic aneurysm. abdominal aortic aneurysm caveolae hypertension mouse model signalling mechanism vascular smooth muscle • Although contribution...
Includes: Supplementary data
Clin Sci (Lond) (2014) 126 (8): 567–580.
Published: 08 December 2013
...) challenge of HDM-sensitized and challenged mice were insensitive to oral prednisone therapy. In summary we have described a CS-resistant mouse model mimicking the key aspects of viral asthma exacerbation using the clinically relevant aeroallergen HDM and the viral mimic poly(I:C). This model may provide...
Clin Sci (Lond) (2013) 125 (12): 565–574.
Published: 02 August 2013
... in an HDM (house dust mite) mouse model of asthma and assess the effect of oral corticosteroids. HDM alone significantly increased eosinophils, lymphocytes, neutrophils, macrophages and a number of cytokines in BAL (bronchoalveolar lavage), all of which were sensitive to treatment with prednisolone...
Clin Sci (Lond) (2007) 112 (6): 325–335.
Published: 12 February 2007
... 2006 10 10 2006 The Biochemical Society 2007 adhesion molecule glomerular basement membrane filtration barrier mouse model podocyte slit diaphragm Podocytes are highly differentiated epithelial cells that contribute to the size-selective nature of the glomerular filtration...