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Keywords: multidrug resistance
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Articles

Methylglyoxal-induced dicarbonyl stress in aging and disease: first steps towards glyoxalase 1-based treatments

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Naila Rabbani, Mingzhan Xue, Paul J. Thornalley
Journal: Clinical Science
Clin Sci (Lond) (2016) 130 (19): 1677–1696.
https://doi.org/10.1042/CS20160025
Published: 23 August 2016
... failure respectively, where it contributes to the development of metabolic and vascular complications. Increased glyoxalase 1 expression confers multidrug resistance to cancer chemotherapy and has relatively high prevalence in liver, lung and breast cancers. Studies of dicarbonyl stress are providing...
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Articles

Modulation of Multidrug Resistance Gene ( mdr-1 ) with Antisense Oligodeoxynucleotides

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Chao Liu, Imran Ahmad Qureshi, Xun-Jie Ding, Yi-Fei Shan, Yi-Wei Huang, YI Xie, Mei-Rong Ji
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (1): 93–98.
https://doi.org/10.1042/cs0910093
Published: 01 July 1996
...Chao Liu; Imran Ahmad Qureshi; Xun-Jie Ding; Yi-Fei Shan; Yi-Wei Huang; YI Xie; Mei-Rong Ji 1. Multidrug resistance is the major obstacle to successful cancer chemotherapy. Circumventing multidrug resistance therefore represents a high priority for clinical anti-cancer treatment. Among many...
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