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Articles

Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle

Anwar Khan, Sherouk Fouda, Ali Mahzari, Stanley M.H. Chan, Xiu Zhou, Cherubina Ratnam, Ross Vlahos, Ji-Ming Ye
Journal: Clinical Science
Clin Sci (Lond) (2020) 134 (13): 1659–1673.
https://doi.org/10.1042/CS20200173
Published: 01 July 2020
... to muscles to offset the supposed benefit of reduced body weight gain on insulin signalling in this major site for glucose tolerance (or insulin action). The study was conducted in mice exposed to chronic CS followed by either a chow (CH) diet or a high-fat (HF) diet. CS increased triglyceride (TG) levels...
View article titled, Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to <span class="search-highlight">muscle</span>
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Includes: Supplementary data
Articles

Ischaemia and insulin, but not ischaemia and contraction, act synergistically in stimulating muscle glucose uptake in vivo in humans

Marlies Bosselaar, Paul Smits, Cees J. Tack
Journal: Clinical Science
Clin Sci (Lond) (2009) 116 (2): 157–164.
https://doi.org/10.1042/CS20080087
Published: 15 December 2008
...Marlies Bosselaar; Paul Smits; Cees J. Tack Ischaemia, like muscle contraction, has been reported to induce skeletal muscle glucose uptake in in vitro models. This stimulating effect appears independent of insulin and is probably mediated by activation of AMPK (AMP-activated protein kinase...
View article titled, Ischaemia and insulin, but not ischaemia and contraction, act synergistically in stimulating <span class="search-highlight">muscle</span> glucose uptake in vivo in humans
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Articles

Effect of hypothermia and HTK on the microcirculation in the rat cremaster muscle after ischaemia

Jacqueline BASTIAANSE, Dick W. SLAAF, Mirjam G. A. oude EGBRINK, Gary L. ANDERSON, Hans VINK, Brigitte E. P. A. van der HEIJDEN, Moshe KON
Journal: Clinical Science
Clin Sci (Lond) (2005) 109 (1): 117–123.
https://doi.org/10.1042/CS20040154
Published: 23 June 2005
...Jacqueline BASTIAANSE; Dick W. SLAAF; Mirjam G. A. oude EGBRINK; Gary L. ANDERSON; Hans VINK; Brigitte E. P. A. van der HEIJDEN; Moshe KON Hypothermia is an important preservation method for tissues and solid organs. The aim of the present study was to assess in rat cremaster muscle the effect...
View article titled, Effect of hypothermia and HTK on the microcirculation in the rat cremaster <span class="search-highlight">muscle</span> after ischaemia
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Articles

Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis

Maaike J. BRUINS, Nicolaas E.P. DEUTZ, Peter B. SOETERS
Journal: Clinical Science
Clin Sci (Lond) (2003) 104 (2): 127–141.
https://doi.org/10.1042/cs1040127
Published: 10 January 2003
...-constant infusions of p -aminohippurate and 3 H-labelled isotopes were used to measure glucose, amino acid and protein metabolism across the portal-drained viscera, liver and hindquarters (to represent muscle) at 0 and 24h of endotoxaemia. Whole-body protein and glucose flux were increased during...
View article titled, Aspects of organ protein, amino acid and glucose metabolism in a porcine model of hypermetabolic sepsis
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Articles

Sequential changes in in vivo muscle and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat

Michael J. O'LEARY, Colin N. FERGUSON, Michael J. RENNIE, Charles J. HINDS, John H. COAKLEY, Victor R. PREEDY
Journal: Clinical Science
Clin Sci (Lond) (2001) 101 (3): 295–304.
https://doi.org/10.1042/cs1010295
Published: 15 August 2001
...Michael J. O'LEARY; Colin N. FERGUSON; Michael J. RENNIE; Charles J. HINDS; John H. COAKLEY; Victor R. PREEDY We have investigated sequential changes in skeletal muscle and hepatic protein synthesis following sepsis, and their relationship to changes in circulating and tissue glutamine...
View article titled, Sequential changes in in vivo <span class="search-highlight">muscle</span> and liver protein synthesis and plasma and tissue glutamine levels in sepsis in the rat
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Articles

Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle

Cheng-Hui FANG, Bing-Guo LI, David R. FISCHER, Jing Jing WANG, Herbert A. RUNNELS, John J. MONACO, Per-Olof HASSELGREN
Journal: Clinical Science
Clin Sci (Lond) (2000) 99 (3): 181–187.
https://doi.org/10.1042/cs0990181
Published: 01 August 2000
...Cheng-Hui FANG; Bing-Guo LI; David R. FISCHER; Jing Jing WANG; Herbert A. RUNNELS; John J. MONACO; Per-Olof HASSELGREN There is evidence that burn injury stimulates ubiquitin–proteasome-dependent protein breakdown in skeletal muscle. In this proteolytic pathway, protein substrates are conjugated...
View article titled, Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal <span class="search-highlight">muscle</span>
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Articles

Effects in vivo of decreased plasma and intracellular muscle glutamine concentration on whole-body and hindquarter protein kinetics in rats

Steven W. M. OLDE DAMINK, Ivo DE BLAAUW, Nicolaas E. P. DEUTZ, Peter B. SOETERS
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 639–646.
https://doi.org/10.1042/cs0960639
Published: 11 May 1999
... and intracellular muscle glutamine depletion. Under these conditions, decreased intramuscular glutamine concentration correlates with reduced rates of protein synthesis. It has therefore been hypothesized that intracellular muscle glutamine levels have a regulatory role in muscle protein turnover rates...
View article titled, Effects in vivo of decreased plasma and intracellular <span class="search-highlight">muscle</span> glutamine concentration on whole-body and hindquarter protein kinetics in rats
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Articles

Predicting composition of leg sections with anthropometry and bioelectrical impedance analysis, using magnetic resonance imaging as reference

N. J. FULLER, C. R. HARDINGHAM, M. GRAVES, N. SCREATON, A. K. DIXON, L. C. WARD, M. ELIA
Journal: Clinical Science
Clin Sci (Lond) (1999) 96 (6): 647–657.
https://doi.org/10.1042/cs0960647
Published: 11 May 1999
...N. J. FULLER; C. R. HARDINGHAM; M. GRAVES; N. SCREATON; A. K. DIXON; L. C. WARD; M. ELIA Magnetic resonance imaging (MRI) was used to evaluate and compare with anthropometry a fundamental bioelectrical impedance analysis (BIA) method for predicting muscle and adipose tissue composition in the lower...
View article titled, Predicting composition of leg sections with anthropometry and bioelectrical impedance analysis, using magnetic resonance imaging as reference
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Articles

Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate

Bernadette A. C. VAN ACKER, Karel W. E. HULSEWÉ, Anton J. M. WAGENMAKERS, Nicolaas E. P. DEUTZ, Bernard K. VAN KREEL, Dave HALLIDAY, Dwight E. MATTHEWS, Peter B. SOETERS, Maarten F. VON MEYENFELDT
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (3): 339–346.
https://doi.org/10.1042/cs0950339
Published: 01 September 1998
... the proportion of glutamine appearing in plasma directly due to its release from protein. 3. The glutamine tracer entered muscle, but the rise in intramuscular glutamine enrichment was small, presumably as a result of the enormous size of the intramuscular glutamine pool and the limited speed of entry...
View article titled, Absence of glutamine isotopic steady state: implications for the assessment of whole-body glutamine production rate
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Articles

Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats

Cheng-Hui FANG, Jing Jing WANG, Scott HOBLER, Bing Guo LI, Josef E. FISCHER, Per-Olof HASSELGREN
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (2): 225–233.
https://doi.org/10.1042/cs0950225
Published: 01 August 1998
...Cheng-Hui FANG; Jing Jing WANG; Scott HOBLER; Bing Guo LI; Josef E. FISCHER; Per-Olof HASSELGREN 1. Burn injury stimulates ubiquitin-dependent protein breakdown in skeletal muscle. The 20S proteasome is the proteolytic core of the 26S proteasome that degrades ubiquitin conjugates. We examined...
View article titled, Proteasome blockers inhibit protein breakdown in skeletal <span class="search-highlight">muscle</span> after burn injury in rats
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Articles

Clinical and therapeutic significance of the Na+,K+ pump

Torben CLAUSEN
Journal: Clinical Science
Clin Sci (Lond) (1998) 95 (1): 3–17.
https://doi.org/10.1042/cs0950003
Published: 01 July 1998
... muscle by insulin, catecholamines, β 2 -agonists or theophylline increases the intracellular uptake of K + and accounts for the hypokalaemia elicited by these agents. Conversely, digitalis intoxication elicits hyperkalaemia via acute inhibition of the Na + ,K + -pump. 2. Simple and accurate methods have...
View article titled, Clinical and therapeutic significance of the Na+,K+ pump
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Articles

Resting Membrane Potential of Skeletal Muscle Calculated from Plasma and Muscle Electrolyte and Water Contents

A. M. Forsberg, J. Bergström, B. Lindholm, E. Hultman
Journal: Clinical Science
Clin Sci (Lond) (1997) 92 (4): 391–396.
https://doi.org/10.1042/cs0920391
Published: 01 April 1997
...A. M. Forsberg; J. Bergström; B. Lindholm; E. Hultman 1. A method is described that enables the calculation of resting membrane potential from the electrolyte and water contents in blood plasma and in a sample of human muscle tissue obtained by the percutaneous needle-biopsy technique...
View article titled, Resting Membrane Potential of Skeletal <span class="search-highlight">Muscle</span> Calculated from Plasma and <span class="search-highlight">Muscle</span> Electrolyte and Water Contents
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Articles

Effects of Hormone Replacement Therapy on Muscle Performance and Balance in Post-Menopausal Women

Alison L. Armstrong, Janet Oborne, Carol A. C. Coupland, Marion B. MacPherson, E. Joan Bassey, W. Angus Wallace
Journal: Clinical Science
Clin Sci (Lond) (1996) 91 (6): 685–690.
https://doi.org/10.1042/cs0910685
Published: 01 December 1996
...Alison L. Armstrong; Janet Oborne; Carol A. C. Coupland; Marion B. MacPherson; E. Joan Bassey; W. Angus Wallace 1. A randomized controlled trial of the effect of oral hormone replacement therapy plus calcium compared with calcium alone on balance, muscle performance and falls was conducted over 48...
View article titled, Effects of Hormone Replacement Therapy on <span class="search-highlight">Muscle</span> Performance and Balance in Post-Menopausal Women
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Articles

Fasting Increases the Extent of Muscle Necrosis in the mdx Mouse

T. R. Helliwell, P. A. MacLennan, A. McArdle, R. H. T. Edwards, M. J. Jackson
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (6): 467–472.
https://doi.org/10.1042/cs0900467
Published: 01 June 1996
...T. R. Helliwell; P. A. MacLennan; A. McArdle; R. H. T. Edwards; M. J. Jackson 1. The effects of fasting for 48 h were investigated in CS7BL/10 (wild type) and age-matched C57BL/10 dystrophin-deficient ( mdx ) mice. 2. Fasting resulted in an increased percentage of necrotic fibres in muscles from...
View article titled, Fasting Increases the Extent of <span class="search-highlight">Muscle</span> Necrosis in the mdx Mouse
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Articles

Getting Rid of Carbon Dioxide during Exercise

Norman L. Jones, George J. F. Heigenhauser
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (5): 323–335.
https://doi.org/10.1042/cs0900323
Published: 01 May 1996
...Norman L. Jones; George J. F. Heigenhauser © 1996 The Biochemical Society and the Medical Research Society 1996 acid-base, blood carbon dioxide stores muscle physicochemical approach Clinical Science (1996) 90, 323-335 (Printed in Great Britain) Editorial Review 323 Getting rid...
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Articles

Carbohydrate Metabolism in Insulin Resistance: Glucose Uptake and Lactate Production by Adipose and Forearm Tissues in Vivo before and after a Mixed Meal

Simon W. Coppack, Rachel M. Fisher, Sandy M. Humphreys, Mo L. Clark, Jennifer J. Pointon, Keith N. Frayn
Journal: Clinical Science
Clin Sci (Lond) (1996) 90 (5): 409–415.
https://doi.org/10.1042/cs0900409
Published: 01 May 1996
...Simon W. Coppack; Rachel M. Fisher; Sandy M. Humphreys; Mo L. Clark; Jennifer J. Pointon; Keith N. Frayn 1. To examine whether insulin resistance in vivo is manifest equally in both muscle and adipose tissues, we measured arteriovenous glucose and lactate fluxes across forearm (muscle...
View article titled, Carbohydrate Metabolism in Insulin Resistance: Glucose Uptake and Lactate Production by Adipose and Forearm Tissues in Vivo before and after a Mixed Meal
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Articles

Physical Fitness and Insulin Sensitivity in Human Subjects with a Low Insulin Response to Glucose

Jan Pigon, Jan Karlsson, Claes-Göran Östenson
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (2): 187–192.
https://doi.org/10.1042/cs0870187
Published: 01 August 1994
...Jan Pigon; Jan Karlsson; Claes-Göran Östenson 1. We have assessed insulin secretion, insulin sensitivity, exercise capacity and muscle fibre composition in healthy men with a low insulin response to glucose (low insulin responders and endurance-trained subjects) and in healthy men with a normally...
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Articles

Dietary Protein and the Regulation of Long-Bone and Muscle Growth in the Rat

Z. A. H. Yayha, D. Joe Millward
Journal: Clinical Science
Clin Sci (Lond) (1994) 87 (2): 213–224.
https://doi.org/10.1042/cs0870213
Published: 01 August 1994
...Z. A. H. Yayha; D. Joe Millward 1. We report here studies of the interrelationship of bone and muscle growth in the rat and the regulatory role of dietary protein. Two experiments were undertaken. In experiment 1, growth inhibition was induced by ad libitum feeding of low protein diets containing 7...
View article titled, Dietary Protein and the Regulation of Long-Bone and <span class="search-highlight">Muscle</span> Growth in the Rat
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Articles

Tumour and Host Tissue Responses to Branched-Chain Amino Acid Supplementation of Patients with Cancer

M. A. McNurlan, S. D. Heys, K. G. M. Park, J. Broom, D. S. Brown, O. Eremin, P. J. Garlick
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (3): 339–345.
https://doi.org/10.1042/cs0860339
Published: 01 March 1994
...M. A. McNurlan; S. D. Heys; K. G. M. Park; J. Broom; D. S. Brown; O. Eremin; P. J. Garlick 1 Rates of protein synthesis have been measured from the incorporation of 57 mg of l-[1- 13 C]leucine/kg for 90 min into muscle tissue and colorectal tumours removed at surgery from cancer patients. 2...
View article titled, Tumour and Host Tissue Responses to Branched-Chain Amino Acid Supplementation of Patients with Cancer
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Articles

Forearm Substrate Utilization during Exercise after a Meal Containing Both Fat and Carbohydrate

A. John Griffiths, Sandy M. Humphreys, Mo L. Clark, Keith N. Frayn
Journal: Clinical Science
Clin Sci (Lond) (1994) 86 (2): 169–175.
https://doi.org/10.1042/cs0860169
Published: 01 February 1994
... 1993 © 1994 The Biochemical Society and the Medical Research Society 1994 chylomicrons dietary fat forearm exercise glucose muscle non-esterified fatty acids triacylglycerol Clinical Science (1994) 116, 16F175 (Printed in Great Britain) Forearm substrate utilization during exercise...
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Articles

Interpretation of Oxygen and Carbon Dioxide Exchange across Tissue Beds in vivo

Keith N. Frayn, Patricia Lund, Mark Walker
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (4): 373–384.
https://doi.org/10.1042/cs0850373
Published: 01 October 1993
...Keith N. Frayn; Patricia Lund; Mark Walker © 1993 The Biochemical Society and the Medical Research Society 1993 adipose tissue arteriovenous differences carbon dioxide indirect calorimetry muscle oxygen respiratory quotient substrate oxidation Clinical S c i i e (1993) 85, 373...
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Articles

Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine

Peter E. Ballmer, Margaret A. McNurlan, Ian Grant, Peter J. Garlick
Journal: Clinical Science
Clin Sci (Lond) (1993) 85 (3): 337–342.
https://doi.org/10.1042/cs0850337
Published: 01 September 1993
...Peter E. Ballmer; Margaret A. McNurlan; Ian Grant; Peter J. Garlick 1. The influence of an acute-phase reaction on the ability of protein synthesis rates in liver and three different muscles (gastrocnemius, soleus and heart) to respond to a short intravenous infusion of nutrients (glucose plus...
View article titled, Responses of Tissue Protein Synthesis to Nutrient Intake in Rats Exposed to Interleukin-1 β Or Turpentine
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Articles

Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique

David L. Chinkes, Judah Rosenblatt, Robert R. Wolfe
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (2): 177–183.
https://doi.org/10.1042/cs0840177
Published: 01 February 1993
.... The traditional equation gives a maximal value for the fractional synthesis rate. 3. When data from the literature are considered, the fractional synthesis rate of muscle protein as calculated by the constant infusion technique falls between the values of fractional synthesis rate calculated by the two flooding...
View article titled, Assessment of the mathematical issues involved in measuring the fractional synthesis rate of protein using the flooding dose technique
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Articles

Glycerol exchange across the human forearm assessed by a combination of tracer and arteriovenous exchange techniques

M. Elia, K. Khan, G. Calder, A. Kurpad
Journal: Clinical Science
Clin Sci (Lond) (1993) 84 (1): 99–104.
https://doi.org/10.1042/cs0840099
Published: 01 January 1993
...M. Elia; K. Khan; G. Calder; A. Kurpad 1. Whole-body kinetics and regional exchange of glycerol across forearm muscle were assessed in eight lean subjects by a combination of a tracer method (infusion of [ 2 H 5 ]glycerol) and arteriovenous catheterization. 2. During an apparent steady state...
View article titled, Glycerol exchange across the human forearm assessed by a combination of tracer and arteriovenous exchange techniques
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Articles

Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs

N. E. P. Deutz, P. L. M. Reijven, G. Athanasas, P. B. Soeters
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (5): 607–614.
https://doi.org/10.1042/cs0830607
Published: 01 November 1992
... metabolism possibly represents an indication of increased substrate utilization by the immune system. Clinical Science (1992) 83, 607-614 (Printed in Great Britain) Post-operative changes in hepatic, intestinal, splenic and muscle fluxes of amino acids and ammonia in pigs N. E. P. DEUTZ, P. L. M. REIJVEN, G...
View article titled, Post-operative changes in hepatic, intestinal, splenic and <span class="search-highlight">muscle</span> fluxes of amino acids and ammonia in pigs
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Articles

Analysis of factors limiting maximal exercise performance in cystic fibrosis

Larry C. Lands, George J. F. Heigenhauser, Norman L. Jones
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (4): 391–397.
https://doi.org/10.1042/cs0830391
Published: 01 October 1992
...Larry C. Lands; George J. F. Heigenhauser; Norman L. Jones 1. Maximal exercise capacity in cystic fibrosis is influenced by both pulmonary and nutritional factors: lung disease by limiting maximal achievable ventilation, and malnutrition through a loss of muscle mass. The associated reduction...
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Articles

Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation

Roger C. Harris, Karin Söderlund, Eric Hultman
Journal: Clinical Science
Clin Sci (Lond) (1992) 83 (3): 367–374.
https://doi.org/10.1042/cs0830367
Published: 01 September 1992
...Roger C. Harris; Karin Söderlund; Eric Hultman 1. The present study was undertaken to test whether creatine given as a supplement to normal subjects was absorbed, and if continued resulted in an increase in the total creatine pool in muscle. An additional effect of exercise upon uptake into muscle...
View article titled, Elevation of creatine in resting and exercised <span class="search-highlight">muscle</span> of normal subjects by creatine supplementation
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Articles

Accumulation of calcium by normal and dystrophin-deficient mouse muscle during contractile activity in vitro

A. McArdle, R. H. T. Edwards, M. J. Jackson
Journal: Clinical Science
Clin Sci (Lond) (1992) 82 (4): 455–459.
https://doi.org/10.1042/cs0820455
Published: 01 April 1992
...A. McArdle; R. H. T. Edwards; M. J. Jackson 1. Accumulation of calcium by extensor digitorum longus muscles from dystrophin-deficient mdx and control C57BL/10 mice has been studied in vitro by measurements of total muscle calcium and by following the retention of 45 Ca resulting from the incubation...
View article titled, Accumulation of calcium by normal and dystrophin-deficient mouse <span class="search-highlight">muscle</span> during contractile activity in vitro
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Articles

Sternomastoid muscle twitch maximum relaxation rate: prolonged slowing with fatigue and post-tetanic acceleration

V. H. F. Mak, F. Chapman, C. James, S. G. Spiro
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (5): 669–676.
https://doi.org/10.1042/cs0810669
Published: 01 November 1991
...V. H. F. Mak; F. Chapman; C. James; S. G. Spiro 1. The maximum rate of relaxation of stimulated twitches (twitch maximum relaxation rate) of the sternomastoid muscle was compared with its frequency-force curve (expressed as the ratio of force produced at a stimulation frequency of 20 Hz...
View article titled, Sternomastoid <span class="search-highlight">muscle</span> twitch maximum relaxation rate: prolonged slowing with fatigue and post-tetanic acceleration
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Articles

Measurement of protein synthesis in human skeletal muscle: further investigation of the flooding technique

M. A. McNurlan, P. Essen, S. D. Heys, V. Buchan, P. J. Garlick, J. Wernerman
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (s25): 557–564.
https://doi.org/10.1042/cs0810557
Published: 01 October 1991
...M. A. McNurlan; P. Essen; S. D. Heys; V. Buchan; P. J. Garlick; J. Wernerman 1. The rate of protein synthesis in quadriceps muscle of healthy subjects estimated from the incorporation of l -[1- 13 C]leucine given by continuous infusion was 1.1%/day. The estimate of protein synthesis from...
View article titled, Measurement of protein synthesis in human skeletal <span class="search-highlight">muscle</span>: further investigation of the flooding technique
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Articles

Elevated endothelial-cell-stimulating angiogenic factor activity in rodent glycolytic skeletal muscles

R. G. Cooper, C. M. Taylor, J. J. Choo, J. B. Weiss
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (2): 267–270.
https://doi.org/10.1042/cs0810267
Published: 01 August 1991
...R. G. Cooper; C. M. Taylor; J. J. Choo; J. B. Weiss 1. Capillary density is greater in skeletal muscles comprised of predominantly oxidative (type I) fibres than in those comprised of mainly glycolytic (type II) fibres. In order to investigate further the angiogenic mechanisms involved in muscle...
View article titled, Elevated endothelial-cell-stimulating angiogenic factor activity in rodent glycolytic skeletal <span class="search-highlight">muscles</span>
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Articles

Effect of glutamine-enriched total parenteral nutrition on septic rats

M. Salleh M. Ardawi
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (2): 215–222.
https://doi.org/10.1042/cs0810215
Published: 01 August 1991
... nutrition resulted in improved nitrogen balance in septic rats: the cumulative nitrogen balance over the 4 days of treatment was the least negative as compared with other groups of septic rats. 4. The rate of loss of intracellular glutamine in skeletal muscle was markedly decreased ( P < 0.001...
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Articles

Effect of insulin on intracellular pH and phosphate metabolism in human skeletal muscle in vivo

D. J. Taylor, S. W. Coppack, T. A. D. Cadoux-Hudson, G. J. Kemp, G. K. Radda, K. N. Frayn, L. L. NG
Journal: Clinical Science
Clin Sci (Lond) (1991) 81 (1): 123–128.
https://doi.org/10.1042/cs0810123
Published: 01 July 1991
...-containing metabolites of normal human skeletal muscle in vivo in four normal subjects. 2. Insulin and glucose were infused for 120 min. Plasma insulin increased approximately 10-fold over pre-clamp levels (5.6 ± 0.9 m-units/l pre-clamp and 54 ± 5 m-units/l over the last hour of infusion; mean ± sem , n = 4...
View article titled, Effect of insulin on intracellular pH and phosphate metabolism in human skeletal <span class="search-highlight">muscle</span> in vivo
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Articles

Evidence for Abnormal Na + /H + Antiport Activity Detected by Phosphorus Nuclear Magnetic Resonance Spectroscopy in Exercising Skeletal Muscle of Patients with Essential Hypertension

C. R. K. Dudley, D. J. Taylor, L. L. Ng, G. J. Kemp, P. J. Ratcliffe, G. K. Radda, J. G. G. Ledingham
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (5): 491–497.
https://doi.org/10.1042/cs0790491
Published: 01 November 1990
...C. R. K. Dudley; D. J. Taylor; L. L. Ng; G. J. Kemp; P. J. Ratcliffe; G. K. Radda; J. G. G. Ledingham 1. Exercise-induced pH changes in skeletal muscle were studied in a group of eight subjects with essential hypertension by using 31 P n.m.r. spectroscopy. 2. Leucocyte Na + /H + antiport activity...
View article titled, Evidence for Abnormal Na + &#x2F;H + Antiport Activity Detected by Phosphorus Nuclear Magnetic Resonance Spectroscopy in Exercising Skeletal <span class="search-highlight">Muscle</span> of Patients with Essential Hypertension
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Articles

Effect of a Test Meal, without and with Protein, on Muscle and Plasma Free Amino Acids

J. Bergström, P. Fürst, E. Vinnars
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (4): 331–337.
https://doi.org/10.1042/cs0790331
Published: 01 October 1990
...J. Bergström; P. Fürst; E. Vinnars 1. The effect of a protein-free meal and a protein-rich meal on the concentration of free amino acids in plasma and muscle tissue was studied in eight healthy subjects. The energy content of the protein-free meal was 3800 kJ. The protein-rich meal was identical...
View article titled, Effect of a Test Meal, without and with Protein, on <span class="search-highlight">Muscle</span> and Plasma Free Amino Acids
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Articles

Glutamine Metabolism in Skeletal Muscle of Glucocorticoid-Treated Rats

M. Salleh M. Ardawi, Yasir S. Jamal
Journal: Clinical Science
Clin Sci (Lond) (1990) 79 (2): 139–147.
https://doi.org/10.1042/cs0790139
Published: 01 August 1990
...M. Salleh M. Ardawi; Yasir S. Jamal 1. The effect of dexamethasone (30 μg day −-1 100 g −-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases...
View article titled, Glutamine Metabolism in Skeletal <span class="search-highlight">Muscle</span> of Glucocorticoid-Treated Rats
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Articles

Ketone body metabolism in lean male adults during short-term starvation, with particular reference to forearm muscle metabolism

M. Elia, S. Wood, K. Khan, E. Pullicino
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (6): 579–584.
https://doi.org/10.1042/cs0780579
Published: 01 June 1990
...%). At 30–36 h and 60–66 h of starvation, essentially all the non-protein energy was derived from the oxidation of fat (directly plus indirectly via ketone bodies). 3. After an overnight fast, acetoacetate and 3-hydroxybutyrate were taken up by forearm muscle at a rate which could account for 5...
View article titled, Ketone body metabolism in lean male adults during short-term starvation, with particular reference to forearm <span class="search-highlight">muscle</span> metabolism
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Articles

Skeletal muscle metabolism in the leg during exercise in patients with congestive heart failure

Pierre-Yves Marie, Jean-Marie Escanye, François Brunotte, Brigitte Robin, Paul Walker, Faiez Zannad, Jacques Robert, Jean-Marie Gilgenkrantz
Journal: Clinical Science
Clin Sci (Lond) (1990) 78 (5): 515–519.
https://doi.org/10.1042/cs0780515
Published: 01 May 1990
... phosphocreatine (PCr) depletion in the working skeletal muscles of the arm. We have studied the importance of the work necessary to reach a similar PCr depletion {[PCr]/([PCr] + [P i ]) = 0.5} in calf muscle. Our results show significantly lower values for patients with congestive heart failure in both aerobic...
View article titled, Skeletal <span class="search-highlight">muscle</span> metabolism in the leg during exercise in patients with congestive heart failure
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Articles

Effects of Insulin on Human Adipose Tissue Metabolism in Vivo

S. W. Coppack, K. N. Frayn, S. M. Humphreys, H. Dhar, T. D. R. Hockaday
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (6): 663–670.
https://doi.org/10.1042/cs0770663
Published: 01 December 1989
... the adipose tissue showed marked positive carbon balance (net substrate deposition). 7 6 1989 23 6 1989 © 1989 The Biochemical Society and the Medical Research Society 1989 adipose tissue free fatty acids glucose glycerol insulin lactate muscle triacylglycerol Clinical Science...
View article titled, Effects of Insulin on Human Adipose Tissue Metabolism in Vivo
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Articles

Human Forearm Arteriovenous Differences of Carnitine, Short-Chain Acylcarnitine and Long-Chain Acylcarnitine

Dr K. Bartlett, A. K. M. J. Bhuiyan, A. Aynsley-Green, P. C. Butler, K. G. M. M. Alberti
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (4): 413–416.
https://doi.org/10.1042/cs0770413
Published: 01 October 1989
.... These observations support the concept that short-chain acylcarnitine (largely acetylcarnitine) contributes to the flux of metabolic fuels from the liver to muscle in the fasted state, although to a limited extent in comparison with 3-hydroxybutyrate (< 5% on a molar basis). 14 3 1989 31 3 1989 ©...
View article titled, Human Forearm Arteriovenous Differences of Carnitine, Short-Chain Acylcarnitine and Long-Chain Acylcarnitine
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Articles

Measurement of the Rate of Protein Synthesis in Muscle of Postabsorptive Young Men by Injection of a ‘Flooding Dose’ of [1- 13 C]leucine

Peter J. Garlick, Jan Wernerman, Margaret A. McNurlan, Pia Essen, Gerald E. Lobley, Eric Milne, Graham A. Calder, Eric Vinnars
Journal: Clinical Science
Clin Sci (Lond) (1989) 77 (3): 329–336.
https://doi.org/10.1042/cs0770329
Published: 01 September 1989
... with the tracer to minimize differences in isotopic enrichment of the free amino acid in plasma and tissue compartments. This approach has been investigated in human muscle by taking biopsies from postabsorptive male volunteers given [1- 13 C]leucine. 2. Intravenous injection of 4 g of unlabelled leucine resulted...
View article titled, Measurement of the Rate of Protein Synthesis in <span class="search-highlight">Muscle</span> of Postabsorptive Young Men by Injection of a ‘Flooding Dose’ of [1- 13 C]leucine
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Articles

Investigation of serum creatine kinase variability after muscle-damaging exercise

Priscilla M. Clarkson, Cara Ebbeling
Journal: Clinical Science
Clin Sci (Lond) (1988) 75 (3): 257–261.
https://doi.org/10.1042/cs0750257
Published: 01 September 1988
...Priscilla M. Clarkson; Cara Ebbeling 1. The present study examined if the presence of creatine kinase (CK) inhibitors might explain the large variability in blood levels of CK among subjects after exercise-induced muscle damage. 2. Twenty-four women performed an eccentric exercise with the forearm...
View article titled, Investigation of serum creatine kinase variability after <span class="search-highlight">muscle</span>-damaging exercise
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Articles

Acute effects of ethanol on protein synthesis in different muscles and muscle protein fractions of the rat

Victor R. Preedy, Timothy J. Peters
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (5): 461–466.
https://doi.org/10.1042/cs0740461
Published: 01 May 1988
...Victor R. Preedy; Timothy J. Peters 1. The effects of a single dose of ethanol (75 mmol/kg body weight) on rates of muscle protein synthesis were examined in young rats. Fractional rates of protein synthesis were measured in the soleus, plantaris, gastrocnemius, diaphragm and stomach by the large...
View article titled, Acute effects of ethanol on protein synthesis in different <span class="search-highlight">muscles</span> and <span class="search-highlight">muscle</span> protein fractions of the rat
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Articles

Muscle strength in the triceps surae and objectively measured customary walking activity in men and women over 65 years of age

E. J. Bassey, M. J. Bendall, M. Pearson
Journal: Clinical Science
Clin Sci (Lond) (1988) 74 (1): 85–89.
https://doi.org/10.1042/cs0740085
Published: 01 January 1988
... of reversing loss of muscle strength through increased daily activity. 15 5 1987 07 7 1987 © 1970 The Biochemical Society and the Medical Research Society 1970 age factors muscle Clinical Science (1988) 74,85-89 85 Muscle strength in the triceps surae and objectively measured...
View article titled, <span class="search-highlight">Muscle</span> strength in the triceps surae and objectively measured customary walking activity in men and women over 65 years of age
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Articles

AMP deaminase deficiency: Study of the human skeletal muscle purine metabolism during ischaemic isometric exercise

S. P. T. Sinkeler, R. A. Binkhorst, E. M. G. Joosten, R. A. Wevers, M. M. Coerwinkel, T. L. Oei
Journal: Clinical Science
Clin Sci (Lond) (1987) 72 (4): 475–482.
https://doi.org/10.1042/cs0720475
Published: 01 April 1987
...S. P. T. Sinkeler; R. A. Binkhorst; E. M. G. Joosten; R. A. Wevers; M. M. Coerwinkel; T. L. Oei 1. Muscle biopsies were taken from 10 control subjects and five AMP deaminase (AMPD) deficient individuals before and after an ischaemic isometric exercise test and analysed for purine nucleotide, NAD...
View article titled, AMP deaminase deficiency: Study of the human skeletal <span class="search-highlight">muscle</span> purine metabolism during ischaemic isometric exercise
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Articles

A study of intracellular orthophosphate concentration in human muscle and erythrocytes by 31 P nuclear magnetic resonance spectroscopy and selective chemical assay

A. Bevington, K. I. Mundy, A. J. P. Yates, J. A. Kanis, R. G. G. Russell, D. J. Taylor, B. Rajagopalan, G. K. Radda
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (6): 729–735.
https://doi.org/10.1042/cs0710729
Published: 01 December 1986
..., at rest, from the flexor digitorum superficialis muscle of hypophosphataemic patients with vitamin D-resistant rickets, and patients with Paget's disease of bone before and after they had been made hyperphosphataemic by treatment with the drug ethylidene-1-hydroxy-1,1-bisphosphonate. Changes...
View article titled, A study of intracellular orthophosphate concentration in human <span class="search-highlight">muscle</span> and erythrocytes by 31 P nuclear magnetic resonance spectroscopy and selective chemical assay
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Articles

Muscle metabolism in patients with peripheral vascular disease investigated by 31 P nuclear magnetic resonance spectroscopy

L. J. Hands, P. J. Bore, G. Galloway, P. J. Morris, G. K. Radda
Journal: Clinical Science
Clin Sci (Lond) (1986) 71 (3): 283–290.
https://doi.org/10.1042/cs0710283
Published: 01 September 1986
...L. J. Hands; P. J. Bore; G. Galloway; P. J. Morris; G. K. Radda 1. Eleven men with claudication and ten control subjects had calf muscle metabolism studied at rest and during exercise and the subsequent recovery period by 31 P nuclear magnetic resonance (n.m.r.) spectroscopy. 2. The muscle...
View article titled, <span class="search-highlight">Muscle</span> metabolism in patients with peripheral vascular disease investigated by 31 P nuclear magnetic resonance spectroscopy
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Articles

Changes in bone and muscle constituents during dieting for obesity

Michael W. J. Davie, Ralph R. Abraham, Belinda Hewins, Victor Wynn
Journal: Clinical Science
Clin Sci (Lond) (1986) 70 (3): 285–293.
https://doi.org/10.1042/cs0700285
Published: 01 March 1986
... increased zinc loss without affecting calcium balance. 30 9 1985 22 10 1985 © 1986 The Biochemical Society and the Medical Research Society 1986 body weight calcium diet reducing muscle tri-iodothyronine zinc Clinical Science (1986).70, 285-293 285 Changes in bone and muscle...
View article titled, Changes in bone and <span class="search-highlight">muscle</span> constituents during dieting for obesity
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Articles

Fatty Acid Oxidation in Mitochondria from Needle Biopsy Samples of Human Skeletal Muscle

K. Gohil, D. A. Jones, R. H. T. Edwards
Journal: Clinical Science
Clin Sci (Lond) (1984) 66 (2): 173–178.
https://doi.org/10.1042/cs0660173
Published: 01 February 1984
...K. Gohil; D. A. Jones; R. H. T. Edwards 1. Activities for the oxidation of palmitoyl-carnitine, of palmitoyl-CoA and of carnitine palmitoyltransferase were measured in mitochondria prepared from needle biopsy samples of human skeletal muscle. Results are presented for nine normal subjects and 18...
View article titled, Fatty Acid Oxidation in Mitochondria from Needle Biopsy Samples of Human Skeletal <span class="search-highlight">Muscle</span>
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Articles

Leucine Uptake by Splanchnic and Leg Tissues in Man: Relative Independence of Insulin Levels

Ljusk Siw Eriksson, Lars Hagenfeldt, Philip Felig, John Wahren
Journal: Clinical Science
Clin Sci (Lond) (1983) 65 (5): 491–498.
https://doi.org/10.1042/cs0650491
Published: 01 November 1983
... role in the disposal of leucine. 19 5 1983 7 6 1983 © 1983 The Biochemical Society and the Medical Research Society 1983 glucose insulin leucine muscle somatostatin splanchnic Clinical Science (1983) 65,491-498 49 1 Leucine uptake by splanchnic and leg tissues in man...
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